UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis

Zhang, Aihua; Wu, Fangfang; Wang, Xijun

doi:10.3390/molecules27103208

Cited by 7 publications

(6 citation statements)

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“…Wolf A total of 16 lipid-related biomarkers were found associated with AD KXS could call back 8 lipid biomarkers that mainly involved in linoleic acid metabolism, arachidonic acid metabolism, and steroid hormone biosynthesis [ 58 ] Guizhi Fuling Wan (GFW) Cinnamomum cassia Presl, Poria cocos(Schw.) Wolf, Paeonia suffruticosa Andr., Prunus persica(L.) Batsch, Paeoniae Radix Rubra A total of 20 differential biomarkers were involved in the disturbed metabolic networks in ECB GFW regulated 10 metabolic pathways including biosynthesis and metabolism of a variety of amino acids, glyoxylic acid and dicarboxylic acid metabolism, citric acid cycle, steroid hormone biosynthesis, primary bile acid biosynthesis, aminoacyl tRNA biosynthesis, etc., thus playing a role in the treatment of endometriosis induced by cold coagulation and blood stasis [ 61 ] Yunnan Baiyao Panax Tseng, Dipterocarpus turbinatus, Ajuga pantantha Hand, Inula cappa, Dioscorea nipponica Makino, Rhizoma Dioscoreae, Dioscorea parviflora C. T. Ting, Geranium wilfordii Maxim A total of 28 differential metabolites were found after Yunnan Baiyao treatment, and the coagulation function, blood rheology, pathological results demonstrated, the pathological indexes in rats with epinephrine hydrochloride-induced blood stasis syndrome improved and returned to normal levels It played a therapeutic role by regulating phenylalanine metabolism, taurine and low taurine metabolism, arachidonic acid metabolism, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, etc [ 67 ] Liu Wei Di Huang Wan (LW) Rehmannia glutinosa, Cornus officinalis, Dioscoreae Rhizoma, Moutan Cortex, Poria, Alisma plantago-aquatica A total of 20 potential biomarkers such as creatinine, estrone, cytidine, and glucosamine were found in kidney yin deficiency syndrome LW-treated rats had the most similar metabolic profile to that of the control rats, indicating the greatest efficiency of the formula LW on kidney yin deficiency syndrome [ 73 ] Yin Chen Hao Tang (YCHT) ArtemisiacapillarisThunb, Gardeniae Fructus, Rheum officinale A total of 22 serum biomarkers may be involved in the potential biological chemistry mechanisms of DHJS occurrence YCHT could call back most of the DHJS biomarkers [ 74 ] …”

Section: The Main Application Of Chinmedomicsmentioning

confidence: 99%

Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components

Wang,

Yin,

Kong

et al. 2024

Chin Med

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As an important part of medical science, Traditional Chinese Medicine (TCM) attracts much public attention due to its multi-target and multi-pathway characteristics in treating diseases. However, the limitations of traditional research methods pose a dilemma for the evaluation of clinical efficacy, the discovery of active ingredients and the elucidation of the mechanism of action. Therefore, innovative approaches that are in line with the characteristics of TCM theory and clinical practice are urgently needed. Chinmendomics, a newly emerging strategy for evaluating the efficacy of TCM, is proposed. This strategy combines systems biology, serum pharmacochemistry of TCM and bioinformatics to evaluate the efficacy of TCM with a holistic view by accurately identifying syndrome biomarkers and monitoring their complex metabolic processes intervened by TCM, and finding the agents associated with the metabolic course of pharmacodynamic biomarkers by constructing a bioinformatics-based correlation network model to further reveal the interaction between agents and pharmacodynamic targets. In this article, we review the recent progress of Chinmedomics to promote its application in the modernisation and internationalisation of TCM.

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Section: The Main Application Of Chinmedomicsmentioning

confidence: 99%

Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components

Wang,

Yin,

Kong

et al. 2024

Chin Med

Self Cite

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“…Abnormal changes in blood rheology such as fluidity and viscosity are important pathological mechanisms that progress from blood stasis to the coexistence of blood stasis and toxin. Blood rheology reflects the flow and viscosity of blood, serving as a crucial indicator of the body's blood stasis condition 24 . Compared to the NC group, the WBV at the median shear rate was significantly higher in the disease and DS groups (P < 0.05, P < 0.01).…”

Section: Comparison Of Wbv Pv and Platelet Armentioning

confidence: 99%

Exploring the “gene–metabolite” network of ischemic stroke with blood stasis and toxin syndrome by integrated transcriptomics and metabolomics strategy

Liu,

Cui,

Liu

et al. 2024

Sci Rep

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A research model combining a disease and syndrome can provide new ideas for the treatment of ischemic stroke. In the field of traditional Chinese medicine, blood stasis and toxin (BST) syndrome is considered an important syndrome seen in patients with ischemic stroke (IS). However, the biological basis of IS-BST syndrome is currently not well understood. Therefore, this study aimed to explore the biological mechanism of IS-BST syndrome. This study is divided into two parts: (1) establishment of an animal model of ischemic stroke disease and an animal model of BST syndrome in ischemic stroke; (2) use of omics methods to identify differentially expressed genes and metabolites in the models. We used middle cerebral artery occlusion (MCAO) surgery to establish the disease model, and utilized carrageenan combined with active dry yeast and MCAO surgery to construct the IS-BST syndrome model. Next, we used transcriptomics and metabolomics methods to explore the differential genes and metabolites in the disease model and IS-BST syndrome model. It is found that the IS-BST syndrome model exhibited more prominent characteristics of IS disease and syndrome features. Both the disease model and the IS-BST syndrome model share some common biological processes, such as thrombus formation, inflammatory response, purine metabolism, sphingolipid metabolism, and so on. Results of the “gene–metabolite” network revealed that the IS-BST syndrome model exhibited more pronounced features of complement-coagulation cascade reactions and amino acid metabolism disorders. Additionally, the “F2 (thrombin)–NMDAR/glutamate” pathway was coupled with the formation process of the blood stasis and toxin syndrome. This study reveals the intricate mechanism of IS-BST syndrome, offering a successful model for investigating the combination of disease and syndrome.

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“…Furthermore, DSF has also been widely served as the fundamental herb pair in numerous traditional complex formulas and patent medicines for clinical treatment of cardiac and cerebral vascular diseases, primarily aiming at promoting blood circulation and removing blood stasis. Examples include Xin Ke Shu ( Yang et al, 2018 ), Xin Shu Bao ( Zhang et al, 2022 ) and Shuan Tong Ling ( Mei et al, 2017 ).…”

Section: Ethnopharmacological Relevancementioning

confidence: 99%

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

Xu,

Yu,

Zhang

et al. 2024

Front. Pharmacol.

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Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting blood circulation and removing blood stasis, and was used extensively in the treatment of atherosclerotic cardiac and cerebral vascular diseases over decades. Despite several breakthroughs achieved in the basic research and clinical applications of DSF over the past decades, there is a lack of comprehensive reviews summarizing its features and research, which hinders further exploration and exploitation of this promising formula. This review aims to provide a comprehensive interpretation of DSF in terms of its ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties and pharmacological effects. The related information on Danshen, Shanzha, and DSF was obtained from internationally recognized online scientific databases, including Web of Science, PubMed, Google Scholar, China National Knowledge Infrastructure, Baidu Scholar, ScienceDirect, ACS Publications, Online Library, Wan Fang Database as well as Flora of China. Data were also gathered from documentations, printed works and classics, such as the Chinese Pharmacopoeia, Chinese herbal classics, etc. Three essential avenues for future studies were put forward as follows: a) Develop and unify the standard preparation method of DSF as to achieve optimized pharmacological properties. b) Elucidate the functional mechanisms as well as the rationality and rule for the compatibility art of DSF by focusing on the clinic syndromes together with the subsequent development of preclinic study system in vitro and in vivo with consistent pathological features, pharmacokinetical behaviour and biomarkers. c) Perform more extensive clinical studies towards the advancement of mechanism-based on evidence-based medicine on the safety application of DSF. This review will provide substantial data support and broader perspective for further research on the renowned formula.

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UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis

Cited by 7 publications

References 57 publications

Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components

Chinmedomics: a potent tool for the evaluation of traditional Chinese medicine efficacy and identification of its active components

Exploring the “gene–metabolite” network of ischemic stroke with blood stasis and toxin syndrome by integrated transcriptomics and metabolomics strategy

Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects

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