2019
DOI: 10.1016/j.jchromb.2019.04.029
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UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites

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Cited by 9 publications
(3 citation statements)
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“…This is an important step towards the discovery of novel compounds [ 2 , 9 ]. Dereplication strategies have been applied on several plant species to achieve different objectives such as to selectively isolate bioactive compounds [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…This is an important step towards the discovery of novel compounds [ 2 , 9 ]. Dereplication strategies have been applied on several plant species to achieve different objectives such as to selectively isolate bioactive compounds [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…Compared to mass spectrometry and high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) is another powerful technique with several unique advantages [ 5 , 6 , 7 , 8 ]. NMR is intrinsically quantitative, and it provides several different approaches that are routinely utilized to identify and structurally elucidate molecules of interest [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. In contrast to mass spectrometry, NMR is non-destructive, non-invasive, has extremely high reproducibility permitting researchers to acquire measurements under different experimental conditions (e.g., temperature, time points, and concentrations) often while the same sample is inside the magnet [ 19 , 20 , 21 , 22 , 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…The available literature [ 32 , 33 , 34 , 36 ] highlights the practicality of NMR in drug design studies. For these reasons, NMR spectroscopy is highly sought after in drug development [ 37 , 38 , 39 , 40 , 41 ], for both molecule identification [ 11 , 13 , 14 , 18 , 42 , 43 , 44 , 45 , 46 ] and structural elucidation [ 15 , 16 , 17 , 45 , 47 , 48 , 49 , 50 , 51 ]. NMR has been successfully applied in stereochemistry [ 52 , 53 , 54 , 55 , 56 ] and isomer determination [ 57 , 58 , 59 , 60 , 61 ], in drug-protein interactions studies [ 62 , 63 , 64 ], and in the evaluation of drug toxicity [ 65 , 66 , 67 , 68 ].…”
Section: Introductionmentioning
confidence: 99%