UPLC-MS-ESI-QTOF Analysis and Antifungal Activity of the Spondias tuberosa Arruda Leaf and Root Hydroalcoholic Extracts

Santos, Antônia Thassya Lucas dos; Carneiro, Joara Nályda Pereira; Cruz, Rafael Pereira da; Sales, Débora Lima; Andrade, Jacqueline Cosmo; Almeida, Waltécio de Oliveira; Costa, José Galberto Martins da; Ribeiro, Paulo Riceli Vasconcelos; Brito, Edy Sousa de; Batista, Francisco Lucas Alves; Magalhães, Francisco Ernani Alves; Morais-Braga, Maria Flaviana Bezerra; Coutinho, Henrique Douglas Melo

doi:10.3390/antibiotics8040240

Cited by 12 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, some products are used to modulate, in other words, enhance the effectiveness of antibiotics and may be natural or synthetic products [42][43][44]. In our study, we can see that M. suaveolens extracts were able to modulate the effect of the drug against strains of C. albicans and C. tropicalis, so that the species has compounds that are antifungal agents.…”

Section: Discussionmentioning

confidence: 56%

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

et al. 2020

Self Cite

View full text Add to dashboard Cite

The emergence of fungal resistance to commercial drugs has been a major problem for the WHO. In this context, research with natural products is promising in the discovery of new active substances. Thus, this work evaluated the antifungal effect of a medicinal plant (i.e., Mesosphaerum suaveolens) against strains of the genus Candida, tested the combined effect with the drug fluconazole, and, finally, determined the phenolic constituents present in the species. Initially, aqueous extracts of leaves (AELMs) and aerial parts (AEAPMs) of the species were prepared. For microbiological assays, the minimum fungicidal concentration was determined by broth microdilution, and the combined effect of fluconazole extracts were verified by sub-inhibitory microdilution concentrations (CFM/8) followed by spectrophotometric readings which were used to determine the IC50. HPLC detected the presence of flavonoids and phenolic acids, detecting eight compounds present in the samples of which caffeic acid and quercetin were major components. The AELMs modulated fluconazole activity since it decreased fluconazole’s IC50 from 7.8 µg/mL to an IC50 of 4.7 µg/mL (CA LM 77) and from 28.8 µg/mL to 18.26 µg/mL (CA INCQS 40006) for the C. albicans strains. The AEAPMs were able to potentiate the effect of fluconazole more effectively than the AELMs. Such an effect was significant for the 16 µg/mL concentration for CA LM 77 and 32 µg/mL for CA INCQS 40006. The AEAPMs as well as the AELMs presented clinically relevant activities for C. tropicalis strains. For the C. tropicalis LM 23 strain, the AEPMs obtained an IC50 of 25 µg/mL and the AELMs an IC50 of 359.9 µg/mL.

show abstract

Section: Discussionmentioning

confidence: 56%

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…[41,[47][48][49][50] and Spondias sp. [51][52][53]. Several reports also related to the activity of isolated compounds [29], including cardanol, among others.…”

Section: The Anacardiaceae Familymentioning

confidence: 99%

“…The most prevalent genus was Pistacia, with nine studies [35][36][37][38][39][40][41][42][43], and Schinus, four studies [41; 47-50]. Anacardium occidentale was the species more investigated, with three studies [27][28][29], followed by Cotinus coggyria [30; 31] and Lannea Kerstingii [32,33], Rhus typhina [26;45], and Spondias tuberosa [51][52][53] with two studies. Other species also showed anti-Candida effects, including Mangifera indica [34], Rhus coriaria [44], Schinopsis brasiliensis [46], and Spondias mombin [51].…”

Section: Anacardiaceae Species With Anti-candida Activitymentioning

confidence: 99%

Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis

Oliveira,

Farias,

Franco

et al. 2024

Preprint

View full text Add to dashboard Cite

Fungal infections caused by Candida spp. are responsible for high hospital morbidity and mortality rates. Therefore, there is a continuous search for new antifungal medicines, particularly ones with anti-Candida activity. This review analyzed articles published between 2002 and 2023 considering the anti-Candida activity of chemical compounds identified or isolated in plants of the Anacardiaceae family. In addition, the in-silico prediction of the isolated compounds described was performed. The analysis of 35 studies showed that extracts, essential oils, and compounds from the anti-Candida activity were frequently determined in vitro using the minimum inhibitory concentration (MIC). The most commonly tested species were Candida albicans, C. tropicalis, C. parapsilosis, C. glabrata, C. krusei, and C. guilliermondii, respectively. Essential oils were the most used form (37% of the studies). The isolated compounds with antifungal effects include cardanol, estragole, trans-anethole, β-caryophyllene, myrcene, catechin-3-o-rhamnoside, β-sitosterol-3-O-glucoside, 24Z-isomasticadienolic acid, oleanolic acid, and oleanolic aldehyde. The in-silico evaluation of those isolated compounds revealed the compounds' drug-likeness and possible antifungal activity. However, some of them showed high toxicity. In conclusion, compounds from the Anacardiaceae family show promise for developing new therapeutic antifungal drugs, especially in combination with conventional antifungals.

show abstract

“…Synergism with the fungicide [14] Caulerpa racemosa and Caulerpa lentillifera chloroform, methanol and aqueous extracts Methicillin-resistant S.…”

Section: Candida Strainsmentioning

confidence: 99%

Humans, Animals, Food and Environment: One Health Approach against Global Antimicrobial Resistance

Vitalini

Varoni

2020

Antibiotics

Self Cite

View full text Add to dashboard Cite

Antimicrobial resistance represents one of the most relevant threats to global public health and food security, affecting anyone, of any age, in any country and is responsible for longer hospital stays, higher medical costs and increased mortality. Resistant microorganisms are present in humans, animals, food and the environment, and, therefore, the One Health approach is very promising to counteract antimicrobial resistance, since human health and animal health are connected to each other and with the environment and the latter a potential source of resistant microorganisms. In this context, the need for novel antimicrobial drugs has stimulated the exploration of plant products as a source of novel phytotherapeutics able to reverse antimicrobial resistance when used in combination with conventional antibiotic drugs.

show abstract

UPLC-MS-ESI-QTOF Analysis and Antifungal Activity of the Spondias tuberosa Arruda Leaf and Root Hydroalcoholic Extracts

Cited by 12 publications

References 36 publications

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

In vitro Antibiotic and Modulatory Activity of Mesosphaerum suaveolens (L.) Kuntze against Candida strains

Anti‐Candida Phytochemicals and Isolated Compounds in Anacardiaceae Family—An Updated Review and In‐Silico Analysis

Humans, Animals, Food and Environment: One Health Approach against Global Antimicrobial Resistance

Contact Info

Product

Resources

About