UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions

Alzoman, Nourah Z.; Maher, Hadir M.; Shehata, Shereen M.; Abanmy, Norah O.

doi:10.1002/bmc.4674

Cited by 10 publications

(11 citation statements)

References 31 publications

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“…APG treatment substantially modulates the pharmacokinetics of DAS and pharmacokinetic parameters further validates these where Cmax), AUC (0–t) , AUMC (0-inf_obs) , T 1/2 , Tmax, and MRT and reduced the rate reduced the Vd, Kel, and Cl, thus escalating systemic bioavailability and rate of absorption that is mediated by CYP3 A2, PGP-MDR1, and BCPR/ABCG2. This present study further endorses the previous pharmacokinetic research that demonstrated interactions with CYP3A, Pgp/MDR1, and BCPR/ABCG2 inhibitors enhanced the DAS bioavailability [ 28 ].…”

Section: Discussionsupporting

confidence: 91%

“…The wide spread use of herbs/herbal supplements/herbal medications with an estimated 40 to 60% of the US population with chronic disease and 20–25% patients with prescribed medication procuring herbal supplements [ 26 , 27 ]. DAS has already been linked to a potentially harmful herb/drug interaction [ 11 , 28 , 29 , 30 ]. There is minimal risk associated with APG’s long history of safe use in food, herbs, and herbal supplements.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

et al. 2023

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Dasatinib (DAS), a narrow-therapeutic index drug, Bcr-Abl, and Src family kinases multitarget inhibitor have been approved for chronic myelogenous leukemia (CML) and Ph-positive acute lymphocytic leukemia (Ph+ ALL). Apigenin (APG) has a long history of human usage in food, herbs, health supplements, and traditional medicine, and it poses low risk of damage. The concomitant use of APG containing herbs/foods and traditional medicine may alter the pharmacokinetics of DAS, that probably lead to possible herb–drug interactions. The pharmacokinetic interaction of APG pretreatment with DAS in rat plasma following single and co-oral dosing was successfully deliberated using the UPLC–MS/MS method. The in vivo pharmacokinetics and protein expression of CYP3A2, Pgp-MDR1, and BCPR/ABCG2 demonstrate that APG pretreatment has potential to drastically changed the DAS pharmacokinetics where escalation in the Cmax, AUC(0–t), AUMC(0-inf_obs), T1/2, Tmax, and MRT and reduction in Kel, Vd, and Cl significantly in rats pretreated with APG 40 mg/kg, thus escalating systemic bioavailability and increasing the rate of absorption via modulation of CYP3A2, Pgp-MDR1, and BCPR/ABCG2 protein expression. Therefore, the concomitant consumption of APG containing food or traditional herb with DAS may cause serious life-threatening drug interactions and more systematic clinical study on herb–drug interactions is required, as well as adequate regulation in herbal safety and efficacy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

et al. 2023

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“…Several studies described the LC-MS/MS-based detection method of dasatinib in plasma. [17][18][19] Although these studies developed determination methods for dasatinib with high sensitivity and accuracy, liquid-liquid extraction and solid-phase extraction were chosen for sample…”

Section: Discussionmentioning

confidence: 99%

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats

Yang¹,

Zhang²,

Wang³

et al. 2021

DDDT

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Background and Aim: Dasatinib is approved for the treatment of leukaemia worldwide.Triazole agents such as posaconazole may be used for the control of secondary fungal infection with leukaemia. This work aimed to develop a bioanalytical method to study the potential interaction between dasatinib and posaconazole. Methods: An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was established to measure the plasma concentrations of dasatinib and posaconazole in rats simultaneously. Simple protein precipitation with acetonitrile was applied to extract dasatinib and posaconazole in samples. The chromatographic separation of analytes was conducted on an UPLC BEH C18 column using a mobile phase consisting of 0.1% aqueous formic acid and acetonitrile. Dasatinib and posaconazole were monitored in positive ion mode with the following mass transition pairs: m/z 488.2→401.1 for dasatinib and m/z 701.3→683.4 for posaconazole. The method was successfully applied for pharmacokinetic interaction between dasatinib and posaconazole. Results: The established method expressed good linearity in 1-1000 ng/mL of dasatinib and 5-5000 ng/mL of posaconazole, with limit of detection was 1 ng/mL and 5 ng/mL, respectively. Methodology validations, including accuracy, precision, matrix effect, recovery, and stability, met the US Food and Drug Administration (FDA) acceptance criteria for bioanalytical method validation. Dasatinib strongly inhibited the clearance of posaconazole in vivo, while posaconazole expressed no significant effect on the pharmacokinetics of dasatinib. Conclusion: Dasatinib alters the pharmacokinetics of posaconazole. Attention should be paid to the unexpected risk of adverse clinical outcomes when posaconazole is coadministered with dasatinib.

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“…It is the most frequently used Chinese medicine for the treatment of diabetes. The main components identified in water extract of Radix Astragali (RAE) are isoflavonoids, polysaccharides, triterpenoid saponins, and aminobutyric acid by chemical detection, among which isoflavonoids are the marker compounds (Alzoman et al., 2019). Recent studies have showed RAE could effectively inhibit the activity of α‐glucosidase (Wang, He, et al., 2020; Wang et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of Taraxacum officinale root extract and its synergism with Radix Astragali extract

Chai

Guo

et al. 2021

Food Science & Nutrition

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Taraxacum officinale (dandelion) and Radix Astragali are traditional medicinal and edible plants with high nutritional value. In this study, the synergistic hypoglycemic effect of DRE and Radix Astragali extract (RAE) was evaluated. Our results showed that water extract of dandelion (DRE‐w), mainly containing polysaccharides (63.92 ± 1.82 mg/g), total flavonoid (2.57 ± 0.06 mg/g), total phenolic compounds (8.93 ± 0.34 mg/g), and saponins (0.54 ± 0.05 mg/g), exhibited significantly inhibitory effect on α‐glucosidase and α‐amylase. DRE‐w and RAE had synergistic hypoglycemic effect; we found that DRE‐w and its combination with RAE could relieve the state of insulin resistance in IR‐HepG2 cells. The combination could more significantly increase the glucose consumption and intracellular glycogen content, and improve the activity of hexokinase and pyruvate kinase in IR‐HepG2 cells. In summary, DRE and its combination with RAE can be developed as the drugs or functional foods for diabetes prevention and treatment.

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UPLC–MS/MS study of the effect of dandelion root extract on the plasma levels of the selected irreversible tyrosine kinase inhibitors dasatinib, imatinib and nilotinib in rats: Potential risk of pharmacokinetic interactions

Cited by 10 publications

References 31 publications

Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

Effects of Apigenin on Pharmacokinetics of Dasatinib and Probable Interaction Mechanism

Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats

Hypoglycemic effect of Taraxacum officinale root extract and its synergism with Radix Astragali extract

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