Upper Airway Motion Depicted at Cine MR Imaging Performed during Sleep: Comparison between Young Patients with and Those without Obstructive Sleep Apnea

Donnelly, Lane F.; Surdulescu, Victoria; Chini, Barbara A.; Casper, Keith; Poe, Stacy A.; Amin, Raouf S.

doi:10.1148/radiol.2271020198

Cited by 119 publications

(66 citation statements)

References 31 publications

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“…The limitations of fluoroscopy are both radiation exposure and that one obtains only a plane lateral image. More recently, Donnelly and coworkers (24,25) applied ungated cine MRI to children with OSAS with complex medical conditions. They demonstrated significant fluctuations in airway size during respiration in subjects with OSAS along the entire upper airway compared with control subjects, a finding that is compatible with our results.…”

Section: Discussionmentioning

confidence: 99%

Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome

Arens

Sin

McDonough

et al. 2005

Am J Respir Crit Care Med

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We performed respiratory-gated magnetic resonance imaging to evaluate airway dynamics during tidal breathing in 10 children with obstructive sleep apnea syndrome (OSAS; age, 4.3 Ϯ 2.3 years) and 10 matched control subjects (age, 5.0 Ϯ 2.0 years). We hypothesized that respiratory cycle fluctuations in upper airway cross-sectional area would be larger in children with OSAS. Methods: Studies were performed under sedation. Respiratory gating was performed automatically at 10, 30, 50, 70, and 90% of inspiratory and expiratory volume. Airway cross-sectional area was measured at four ascending oropharyngeal levels at each increment of the respiratory cycle. Results: We noted the following in subjects with OSAS compared with control subjects: (1 ) a smaller upper airway cross-sectional area, particularly during inspiration; (2 ) airway narrowing occurred during inspiration without evidence of complete airway collapse; (3 ) airway dilatation occurred during expiration, particularly early in the phase; and (4 ) magnitude of cross-sectional areas fluctuations during tidal breathing noted in OSAS at levels 1 through 4 were 317, 422, 785, and 922%, compared with 19, 15 17, and 24% in control subjects (p Ͻ 0.001, p Ͻ 0.005, p Ͻ 0.001, and p Ͻ 0.001, respectively). Conclusions: Fluctuations in airway area during tidal breathing are significantly greater in subjects with OSAS compared with control subjects. Resistive pressure loading is a probable explanation, although increased airway compliance may be a contributing factor.

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Section: Discussionmentioning

confidence: 99%

Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome

Arens

Sin

McDonough

et al. 2005

Am J Respir Crit Care Med

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show abstract

“…28 Donnelly et al reported significant differences in the patterns of airway dynamic motion when they compared young OSA patients with subjects without OSA using 3-D imaging. 29 CBCT are now being routinely taken from a cohort of patients receiving orthodontic treatments, TMJ surgeries and dental implant evaluations. Even though CBCT does not have the highest resolution compared to traditional CT scans, its low radiation exposure allows utilization on a variety of clinical patients to collect data for more longitudinal studies.…”

Section: -D Evaluationmentioning

confidence: 99%

Cone beam computed tomography and obstructive sleep apnoea

Strauss

Wang

2012

Australian Dental Journal

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Sleep apnoea is characterized by an intermittent cessation or diminution of airflow during sleep that may result in significant pulmonary and cardiac consequences, and is associated with significant morbidity and mortality. It is a common disease that affects approximately 20% of patients who snore, equating to a total prevalence in the population of about 4% of all middle aged men and 2% of women. In reality, due to lack of recognition and the difficulty with obtaining an accurate diagnosis, the actual incidence is likely much higher.

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“…Other limitations of CT and MRI include motion artifact due to tidal breathing or active airway obstruction, the need for sedation in infants and young children to prevent motion artifact, and cost. Dynamic respiration-gated techniques with CT and MRI have been recently introduced by several groups to study airway dynamics, and may provide functional data based on measures of collapsibility (62,63). The utility of such imaging techniques, along with computation models of upper airway fluid and tissue mechanics are beginning to provide better understanding of the complex anatomical and functional interactions leading to OSAS and other respiratory disorders in both children and adults.…”

Section: Evaluation Of the Upper Airway Using Imaging And Other Technmentioning

confidence: 99%

Developmental Aspects of the Upper Airway: Report from an NHLBI Workshop, March 5-6, 2009

Marcus¹,

Smith²,

Mankarious³

et al. 2009

Proceedings of the American Thoracic Society

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Upper Airway Motion Depicted at Cine MR Imaging Performed during Sleep: Comparison between Young Patients with and Those without Obstructive Sleep Apnea

Abstract: There are significant differences in the patterns of dynamic airway motion between young patients with and those without OSA.

Cited by 119 publications

References 31 publications

Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome

Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome

Cone beam computed tomography and obstructive sleep apnoea

Developmental Aspects of the Upper Airway: Report from an NHLBI Workshop, March 5-6, 2009

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