Upper Gastrointestinal Bleed due to Duodenal Metastases of Lung Adenocarcinoma: Report of Two Cases and Review of Literature

Kosasih, Sumitro; Nawawi, Khairul Najmi Muhammad; Wong, Zhiqin; Chew, Deborah; A, Bán; Ali, Raja Affendi Raja

doi:10.1155/2019/3437056

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…This agrees with Wang et al 50 . A relatively normal PAS staining intensity, similar to the control, was observed in silymarin, AFPD and EFPD treated groups and this is in tandem with Adil et al 51 , Kosasih et al 52 and Amber et al 18 who reported that the nephroprotective potential of plants extracts could be attributed to its phytoconstituents such as polyphenolic compounds.…”

Section: Discussionsupporting

confidence: 76%

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Abubakar,

Agbon,

Musa

et al. 2024

Preprint

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Introduction: Mercury is a highly toxic metal that exerts adverse effects on humans and animals. Date palm (Phoenix dactylifera) is used in folk medicine to treat fever, and inflammation, among others. The present study aimed to evaluate the protective effects of aqueous and ethanol extracts of Phoenix dactylifera on mercury-induced kidney damage in Wistar rats.Design: 45 male rats (80–125g) were divided into nine groups (I-XI). Group 1 received 1mg/kg of distilled water, group II received mercury chloride (HgCl2) at 5 mg/kg; group III was pretreated with100 mg/kg of silymarin followed by 5 mg/kg of HgCl2; groups IV and V were pretreated with 500 mg/kg and 1000 mg/kg of aqueous extract of Phoenix dactylifera (AFPD) respectively, followed by 5 mg/kg of HgCl2; groups VI and VII were pretreated with 500 mg/kg and 1000 mg/kg of ethanol extract of Phoenix dactylifera L. (EFPD) respectively, followed by 5 mg/kg of HgCl2 while group VIII and IX received 1000 mg/kg of AFPD and EFPD respectively. After two weeks of oral administration, the animals were sacrificed and the blood and kidney tissue were collected for analyses.Results The present study showed that MDA significantly increased in HgCl2 group when compared to control while histological and histochemical changes in the kidney revealed severe degenerative changes. AFPD and EFPD extracts restored serum enzymes, electrolytes and antioxidant enzymes activity with significant increase in SOD activity in the AFPD (high dose) when compared to the HgCl2 treated group. This indicates some level of protection against HgCl2-induced changes in the kidneys of Wistar rats. The protective activity of the AFPD and EFPD may be attributed to the antioxidant properties of the phytochemicals, such as flavonoids, tannins etc.Conclusion The aqueous and ethanol extracts of Phoenix dactylifera are potential candidates for the management and treatment of ROS-induced kidney diseases.

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Section: Discussionsupporting

confidence: 76%

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Abubakar,

Agbon,

Musa

et al. 2024

Preprint

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“…GIT metastasis from primary lung carcinoma are rare with an incidence ranging from 4.7 to 14% in autopsy studies [1,2]. This incidence is much lower when patients are alive ranging from 0,3 to 1,8% [3,4] because of the asymptomatic course of the disease most often [5]. The existence of a table involving simple acute abdominal pain without perforation, as found in our case, remains exceptional [7,8].…”

Section: Discussionmentioning

confidence: 58%

“…Ito, et al, demonstrated that chemo-radiotherapy with four cycles of cisplatin and etoposide, followed by abdominal irradiation at a dose of 30 Gy to patients with small cell lung cancer with GI metastasis have reasonably good partial response. Zhou, et al, highlighted the potential benefit of tyrosine kinase inhibitors [TKI] in primary lung cancer with driver gene mutations in gastrointestinal metastases [4]. In addition, targeted vascular therapies have gained acceptance in recent years.…”

Section: Discussionmentioning

confidence: 99%

Caecal Metastasis: An Exceptional Manifestation Mode Revealing Small Cell Lung Carcinoma: Clinical Case and Review of the Literature

Makhlouf¹,

Dahmani²,

Hamdani³

et al. 2021

Mathews Journal of Gastroenterology and Hepatology

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Lung cancer is the leading cause of death worldwide. Almost 50% of patients present with distant metastasis at the moment of diagnosis. The most common metastasis sites are lymph nodes, liver, adrenal glands, bones, and brain. However, gastrointestinal tract (GIT) metastasis from primary lung carcinoma is a rare phenomenon and it is considered a late stage of the disease, generally detected in patients with a documented previous history of a primary lung malignancy. By contrast, the finding of a lung cancer initially manifesting with GI-tract involvement is extremely rare and it is usually reported in the literature in isolated case reports. This case study involves a 70 year-old-man, initially presenting with digestive symptoms related to caecal metastasis from primary lung carcinoma.

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“…Small bowel metastasis has a relatively worse prognosis as it often leads to perforation [4,8]. Table 1 shows other presentations of adenocarcinoma that have a similar pathologic diagnosis to our patient's case [9][10][11][12][13][14][15][16]. Early detection, diagnosis, and treatment are crucial for improving patient outcomes in duodenal metastasis from primary lung cancer, which often goes unnoticed due to its benign clinical presentation, low incidence, and diagnostic challenges.…”

Section: Discussionmentioning

confidence: 62%

Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

Aldecoa,

Frame,

Satei

et al. 2023

Cureus

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The incidence of lung cancer metastasizing to the duodenum is rare, and its clinical presentation is still not fully understood due to its low frequency. It can be asymptomatic or present symptomatically in various ways. Here, we present the case of a 63-year-old female with an unusual case of duodenal metastasis from pulmonary adenocarcinoma, presenting with a new-onset seizure complicated by a fracture from a post-ictal fall. The diagnosis of anemia secondary to duodenal metastasis from lung cancer was delayed due to this sequence of events. The patient was ultimately found to have a circumferential mass in the third portion of the duodenum on esophagogastroduodenoscopy, which was found to be consistent with metastatic pulmonary adenocarcinoma on pathological examination.

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Upper Gastrointestinal Bleed due to Duodenal Metastases of Lung Adenocarcinoma: Report of Two Cases and Review of Literature

Cited by 5 publications

References 16 publications

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Biochemical, Morphological and Molecular Assessments of Flavonoids of Phoenix dactylifera L. Following Exposure to Inorganic Mercury on the Liver of Wistar Rats.

Caecal Metastasis: An Exceptional Manifestation Mode Revealing Small Cell Lung Carcinoma: Clinical Case and Review of the Literature

Delayed Diagnosis of Duodenal Metastasis From Primary Lung Adenocarcinoma: A Case Report

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