Upper gastrointestinal bleeding in patients with end stage renal disease: causes, characteristics and factors associated with need for endoscopic therapeutic intervention

Laeeq, Syed Mudassir; Tasneem, Abbas Ali; Hanif, Farina; Luck, Nasir Hassan; Mandhwani, Rajesh; Wadhva, Rajesh Kumar

doi:10.1515/jtim-2017-0019

Cited by 19 publications

(21 citation statements)

References 17 publications

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“…Laeeq et al described the causes and characteristics of UGIB in ESRD patients and found that the most common findings were erosions (55.9%) and ulcers (30.3%). More than half (55.9%) of patients required therapeutic intervention [22].…”

Section: Anemia and Gi Bleeding In Ckdmentioning

confidence: 99%

Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease

Muftah¹

2019

aog

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Recurrent obscure gastrointestinal bleeding amongst patients with chronic kidney disease is a challenging problem gastroenterologists are facing and is associated with an extensive diagnostic workup, limited therapeutic options, and high healthcare costs. Small-bowel angiodysplasia is the most common etiology of obscure and recurrent gastrointestinal bleeding in the general population. Chronic kidney disease is associated with a higher risk of gastrointestinal bleeding and of developing angiodysplasia compared with the general population. As a result, recurrent bleeding in this subgroup of patients is more prevalent and is associated with an increased number of endoscopic and radiographic procedures with uncertain benefit. Alternative medical therapies can reduce re-bleeding; however, more studies are needed to confirm their efficacy in this subgroup of patients.

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Section: Anemia and Gi Bleeding In Ckdmentioning

confidence: 99%

Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease

Muftah¹

2019

aog

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“…Several studies have demonstrated high mortality with higher Rockall scores[ 6 ]. However, Laeeq et al[ 7 ] have not found significantly higher mortality in patients with high pre-endoscopic Rockall score (> 5). The Rockall score only assesses the risk of mortality in patients with upper GI bleeding.…”

Section: Introductionmentioning

confidence: 99%

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis

Hágendorn

Farkas

Vincze

et al. 2017

WJG

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AIMTo understand the influence of chronic kidney disease (CKD) on mortality, need for transfusion and rebleeding in gastrointestinal (GI) bleeding patients.METHODSA systematic search was conducted in three databases for studies on GI bleeding patients with CKD or end-stage renal disease (ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization (LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane’s Q and I2 statistics. Mean difference (MD) and OR (odds ratio) were calculated.RESULTS1063 articles (EMBASE: 589; PubMed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group (OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group (OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate (OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion (MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital (MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSIONESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed.

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“…Patients with gastric glomus tumor can present different symptoms, such as abdominal discomfort or pain, and gastric glomus tumor is one of rare causes of gastrointestinal hemorrhage. [11][12][13][14] One patient (1/11) presented with upper gastrointestinal bleeding in our report.…”

Section: Disscussionmentioning

confidence: 56%

The role of endoscopic ultrasound and endoscopic resection for gastric glomus: A case series and literature review

Guo

Wang

et al. 2019

Journal of Translational Internal Medicine

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Background and Objectives Preoperative diagnosis of gastric glomus tumor is very difficult, and there are few reports regarding the endoscopic treatment of glomus tumor of the stomach. Our aim is to provide a retrospective assessment of the imaging features of endoscopic ultrasound (EUS) and treatment of choice of gastric glomus tumor. Methods A database of all patients with gastric glomus tumor who was treated at Shengjing Hospital of China Medical University between March 2011 and March 2017 was retrospectively analyzed. The EUS characteristics and patients’ clinical data as well as their treatment were reviewed. At the same time, we compared EUS characteristics of gastric glomus tumor with that of gastrointestinal stromal tumor (GISTs), leiomyomas, schwannomas, and ectopic pancreas. Results Eleven patients (3 male and 8 female patients) were included in the present study. The patients’ age ranged from 37 to 62 years (mean age, 50.1 years). Ten patients received EUS examination. Eight lesions were presented with mild-hyperechoic round or oval mass; one lesion was mild-hyperechoic oval mass with hypoechoic spots; one lesion was hypoechoic oval mass. One patient received endoscopic full-thickness resection; 3 patients were treated by endoscopic submucosal dissection; and laparoscopic resection was performed for 7 patients. Conclusions Gastric glomus has typical EUS features to differentiate from other submucosal tumors. Compared with surgery, endoscopic resection is also a safe and effective treatment of choice for gastric glomus tumor.

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Upper gastrointestinal bleeding in patients with end stage renal disease: causes, characteristics and factors associated with need for endoscopic therapeutic intervention

Cited by 19 publications

References 17 publications

Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease

Diagnostic and therapeutic considerations for obscure gastrointestinal bleeding in patients with chronic kidney disease

Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis

The role of endoscopic ultrasound and endoscopic resection for gastric glomus: A case series and literature review

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