Upper gastrointestinal diseases in patients for endoscopy in South-Western Uganda

Obayo, Siraji; Muzoora, Conrad; Ocama, Ponsiano; Cooney, Matthew M.; Wilson, Tony; Probert, Chris

doi:10.4314/ahs.v15i3.33

Cited by 24 publications

(34 citation statements)

References 14 publications

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“…In the present study, associations were found between H. pylori and each of gastritis and gastric ulcer, which agree with the results from Uganda [22]. These findings occurred because infection with H. pylori can increase the "proinflammatory cytokine gene expressions in gastric epithelial cells by stimulation of NF-kB signalling" which may be implicated in causing gastritis and other gastric complications [7].…”

Section: Test Of Significance: Student's T-test or Mann Whitney Test supporting

confidence: 91%

“…In the current study, the commonest complaints of patients with H. pylori infection was Epigastric pain (54.3%) which is in line with results of a study from Uganda [22]. Similarly, findings from another recent Ethiopian study, 2018, revealed that H. pylori was associated with upper GIT complaints such as Epigastric burning/pain [23].…”

Section: Test Of Significance: Student's T-test or Mann Whitney Test supporting

confidence: 90%

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Helicobacter Pylori: Prevalence and Relationship to Hematological Parameters of Symptomatic Patients who Conducted Gastroscopy at King Abdulaziz University Hospital, Jeddah

Ibrahim

Al-Sayes

Alidrous

et al. 2019

JAMMR

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Background: Helicobacter pylori (H. pylori) is one of the most important public health problems worldwide. The study was done to determine the epidemiology of H. pylori, and its relation to the hematological parameters of symptomatic patients who conducted upper gastrointestinal (GIT) endoscopy at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia. Methods: A retrospective cohort study was done during the academic year 2016/2017. All records of the eligible cases who complained from GIT manifestations, and conducted upper GIT Ibrahim et al.; JAMMR, 28(9): 1-9, 2018; Article no.JAMMR.44973 2 endoscopy at KAUH (during 2015) were assessed. Only cases with samples taken from the gastric mucosa and examined by the Rapid Urease Test (RUT) were included. Results of two sets of Complete Blood Count (CBC) before and 6 months after treatment of H. pylori were taken. Cases were interviewed at 2017 for follow-up. Results: Two-thousand patients' files were reviewed with a 29.5% prevalence of H. pylori. The most frequently reported clinical presentation of H. pylori was epigastric pain (54.3%). Males had a significantly higher rate of infection compared to females. H. pylori was associated with gastric ulcer and gastritis. There was no association between H. pylori and the hematological parameters of patients. Treatment of H. pylori caused a little increase in RBCs & hemoglobin level. Conclusions: Nearly thirty percent of the symptomatic patients who conducted upper gastroendoscopy at KAUH were infected with H. pylori. Infection was associated with gastritis and gastric ulcer. There is no association between H. pylori and hematological parameters. Screening and management of symptomatic cases for H. pylori is recommended. Original Research Article

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Section: Test Of Significance: Student's T-test or Mann Whitney Test supporting

confidence: 91%

Section: Test Of Significance: Student's T-test or Mann Whitney Test supporting

confidence: 90%

Helicobacter Pylori: Prevalence and Relationship to Hematological Parameters of Symptomatic Patients who Conducted Gastroscopy at King Abdulaziz University Hospital, Jeddah

Ibrahim

Al-Sayes

Alidrous

et al. 2019

JAMMR

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“…The most common symptoms associated with UD was found to be epigastric pain/burning (42.1%), PPF (26.1%), ES (22.6%) and belching (25.2%) (Table 2 ). Similarly, among Ugandan patients presenting with upper GI symptoms the most common presenting complaint was epigastric pain (51.6%) [ 34 ]. Our result is also in line with study in Iran as epigastric pain or burning (58.3%) being dominant complaint of dyspeptic patients followed by PPF (37.3%) and ES (18.6%) [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Uninvestigated dyspepsia and associated factors of patients with gastrointestinal disorders in Dessie Referral Hospital, Northeast Ethiopia

2018

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BackgroundDyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms’ correlation with H. pylori infection.MethodsA cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015. All patients completed a questionnaire for collecting data regarding sociodemographic, lifestyle and functional gastrointestinal disorders. Diagnosis of dyspepsia was made according to the Rome III criteria. H. pylori infection was assessed using stool antigen test. SPSS version 20.0 statistical software package was used for data analysis.ResultsFrom a total of 318 patients, 48.4% had UD according to Rome III criteria; with 42.1% symptoms of epigastric pain/burning, 26.1% postprandial fullness and 22.6% early satiation. Epigastric pain/burning (AOR = 1.92, 95% CI 1.07–3.43), early satiation (AOR = 2.68, 95% CI 1.38–5.20) and belching (AOR = 4.7, 95% CI 1.54–14.40) were significantly correlated with H. pylori infection. H. pylori infection (AOR = 4.33, 95% CI 2.41–7.76) and aspirin/NSAIDs consumption (AOR = 5.29, 95% CI 2.82–9.93) were independent risk factors for UD. However, consumption of raw fruits/ vegetables at least once a week (AOR = 0.48, 95% CI 0.24–0.98) and taking two or more cups of tea a day (AOR = 0.339, 95% CI 0.17–0.70) were inversely associated with UD.ConclusionsUD is highly prevalent among adults with gastrointestinal complaints. H. pylori infection is significantly associated with UD and correlates with its symptoms. Individuals with epigastric pain/burning, early satiation and belching should be primary focus of H. pylori infection diagnosis and treatment. The role of consumption of tea, raw fruits and vegetables on dyspepsia needs further large scale study.

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“…Other symptoms associated with HP infection were esophageal reflux (9.9%), hematemesis (3.1%), melena stools (3.2%), vomiting (1.5%), and belching (2.1%). 7 Obayo et al 11 also reported that abdominal pain was associated with HP infection in 51.6% of 176 patients from southwestern Uganda with HP infection. Demma et al 4 reported an average annual age-adjusted rate of hospitalizations per 100,000 NA/ANs of 232.4 for ulcer-associated conditions, 14.2 for gastric cancer, and 6.1 for mucosa-associated lymphoid tissue (MALT) lymphoma.…”

Section: Introductionmentioning

confidence: 96%

Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk of <em>Helicobacter pylori</em> infection in the US

Huerta-Franco

Banderas

Allsworth

2018

CEG

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BackgroundIn the US, neither the prevalence nor the gastrointestinal (GI) diagnosis/symptoms associated with Helicobacter pylori (HP) have been examined in different racial/ethnic groups.AimTo determine the racial/ethnic differences in HP infection associated with GI diagnoses/symptoms using the Cerner Health Facts® database.MethodsThis cross-sectional study collected data during the period of 2000–2015 from the following ethnic/racial groups: 8,236,317 white, 2,085,389 black, 426,622 Hispanic, 293,156 Asian Pacific/Islander (APIs), and 89,179 Native American/Alaskan Native (NA/AN) patients aged 21–65 years old; the data were then analyzed. The primary dependent variable was a diagnosis of HP (ICD-9-Clinical Modification/ICD-10 classification). SAS version 9.4 was used for the statistical analysis. The statistical analysis was performed on 11,130,663 patients with GI symptoms, and of these, 152,086 patients were positive for the infection.ResultsHispanics and NA/ANs had the highest prevalence of HP associated with upper GI symptoms/diagnosis. Nevertheless, blacks and APIs presented the highest relative risk (RR) of HP associated with dyspepsia (RR [95% CI] =11.2 [10.7–11.9] and 14.2 [12.8–15.6]), peptic ulcer (RR =13.8 [13.3–14.5] and 10.7 [9.3–12.3]), and atrophic gastritis (RR =9 [8.5–9.6] and 7.4 [6.4–8.5]), respectively. In all racial/ethnic groups, HP was also associated with inflammatory bowel diseases, liver diseases, and celiac diseases.ConclusionBlack and API populations had the highest risk of HP associated with upper GI symptoms/diagnosis. Black patients also had the highest risk for HP associated with GI cancer.

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Upper gastrointestinal diseases in patients for endoscopy in South-Western Uganda

Cited by 24 publications

References 14 publications

Helicobacter Pylori: Prevalence and Relationship to Hematological Parameters of Symptomatic Patients who Conducted Gastroscopy at King Abdulaziz University Hospital, Jeddah

Helicobacter Pylori: Prevalence and Relationship to Hematological Parameters of Symptomatic Patients who Conducted Gastroscopy at King Abdulaziz University Hospital, Jeddah

Uninvestigated dyspepsia and associated factors of patients with gastrointestinal disorders in Dessie Referral Hospital, Northeast Ethiopia

Ethnic/racial differences in gastrointestinal symptoms and diagnosis associated with the risk of <em>Helicobacter pylori</em> infection in the US

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