Upper Gastrointestinal Histopathological Findings in Children and Adolescents With Nonulcer Dyspepsia With Helicobacter pylori Infection

Carvalho, Mary de Assis; Machado, Nilton Carlos; Ortolan, Érika Veruska Paiva; Rodrigues, Maria Aparecida Marchesan

doi:10.1097/mpg.0b013e3182618136

Cited by 40 publications

(47 citation statements)

References 46 publications

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“…Recent epidemiological surveys have found the prevalence of H. pylori infection to be 7-33% in Europe, 48-78% in South America, 37.5-66% in Asia and 87% in South Africa (10). The prevalence observed in the present study (32.1%) is lower than that reported in the inland area of China as well as in some developing countries (10,11), likely for two reasons. First, the known risk factors for H. pylori infection are age, a low socioeconomic status, limited living space, sharing of beds, a low parent education level, pollution of daily used water and H. pylori infection in family members (especially the mother) (12)(13)(14).…”

Section: Discussioncontrasting

confidence: 56%

“…Generally, the patients in the present study had a low prevalence of chronic atrophic gastritis, and no patients had severe chronic atrophic gastritis or intestinal metaplasia. Researchers from different countries have reported a varied incidence of gastric atrophy (0-72%) and intestinal metaplasia ( 0-21% ) in children (11,(25)(26)(27)(28). Genetic and environmental factors other than H. pylori infection may explain the striking differences.…”

Section: Discussionmentioning

confidence: 99%

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Association between Helicobacter pylori Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Wang

et al. 2014

Intern. Med.

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Objective H. pylori infection in children has a high prevalence worldwide. The disease can cause progressive gastric mucosal inflammation, as verified in animal models. However, data from large-scale clinical studies are limited. Methods We examined 1,634 Chinese children with upper gastrointestinal discomfort using endoscopy. The clinical and pathological data of the patients were analyzed. Results A total of 524 (32.1%) patients were infected with H. pylori, and the prevalence of H. pylori infection increased with age. The H. pylori-infected patients exhibited a significantly higher prevalence of active inflammation (26.9% vs. 4.1%), lymphoid follicle formation (18.5% vs. 4.6%) and marked lymphocyte infiltration (19.7% vs. 5.6%). The H. pylori-infected patients also exhibited a significantly higher prevalence of moderate to marked chronic superficial gastritis (41.9% vs. 9.2%) and moderate chronic atrophic gastritis (21.7% vs. 2.6%) than the uninfected patients (p<0.01). Conclusion H. pylori infection is associated with the degree of gastric mucosal inflammation and the severity of different types of chronic gastritis.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter pylori Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Wang

et al. 2014

Intern. Med.

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“…This criterion was followed in our series. The results of the macroscopic findings observed in endoscopy coincided with those in previous reports concluding that the presence of antral nodularity has a strong predictive value as a marker of HP infection in children. Antral nodularity can occasionally indicate the presence of mucosa‐associated lymphoid tissue (MALT) .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Montes

F²,

Eizaguirre

et al. 2014

Helicobacter

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“…This is notable considering that IM and atrophy are relatively rare in other reported studies of pediatric gastritis 6,21, 22 . As CDX2 is expressed early in the IM progression pathway, ectopic antral CDX2 probably reflects pathologic changes leading to IM 3 .…”

Section: Discussionmentioning

confidence: 65%

Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori–positive and Helicobacter pylori–negative gastritis

Villarreal-Calderon

Luévano-González

Aragón-Flores

et al. 2014

Annals of Diagnostic Pathology

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Chronic inflammation and infection are major risk factors for gastric carcinogenesis in adults. As chronic gastritis is common in Mexican children, diagnosis of Helicobacter pylori and other causes of gastritis are critical for the identification of children who would benefit from closer surveillance. Antral biopsies from 82 Mexican children (mean age 8.3±4.8y) with chronic gastritis (36 H. pylori +, 46 H. pylori -) were examined for gastritis activity, atrophy, intestinal metaplasia, and immunohistochemical expression of gastric carcinogenesis biomarkers CDX2, ephrin type-B receptor 4, matrix metalloproteinase 3 (MMP3), macrophage migration inhibitory factor (MIF), p53, β-catenin, and E-cadherin. Atrophy was diagnosed in 7/82 (9%) and intestinal metaplasia in 5/82 (6%) by routine histology, while 6 (7%) additional children (3 H. pylori +) exhibited aberrant CDX2 expression without intestinal metaplasia. Significant positive correlations were seen between EphB4, MMP3, and MIF (p<0.0001). Atrophy and follicular pathology were more frequent in H. pylori + biopsies (p<0.0001), while intestinal metaplasia and CDX2 expression showed no significant correlation with H. pylori status. Antral biopsies demonstrating atrophy, intestinal metaplasia, and/or aberrant CDX2 expression were seen in 21.95 % (18/82) of the children, potentially identifying those who would benefit from closer surveillance and preventive dietary strategies. Biomarkers CDX2, EphB4, MMP3, and MIF may be useful in the work-up of pediatric gastritis.

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Upper Gastrointestinal Histopathological Findings in Children and Adolescents With Nonulcer Dyspepsia With Helicobacter pylori Infection

Abstract: The prevalence of H pylori infection was high among children with dyspepsia and associated with moderate/severe degrees of gastric inflammation. The high scores of esophagitis in the noninfected group point to 2 distinct groups of pathological conditions sharing similar clinical patterns.

Cited by 40 publications

References 46 publications

Association between <i>Helicobacter pylori</i> Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Association between <i>Helicobacter pylori</i> Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Antral atrophy, intestinal metaplasia, and preneoplastic markers in Mexican children with Helicobacter pylori–positive and Helicobacter pylori–negative gastritis

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