Upper gastrointestinal tract polyps in familial adenomatosis coli.

Järvinen, Heikki; Nyberg, Marcus; Peltokallio, P

doi:10.1136/gut.24.4.333

Cited by 125 publications

(37 citation statements)

References 25 publications

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“…In addition, polypoid adenomas were found in all the patients in the former group. Furthermore, because previous data from surveillance of duodenal lesions in our patients with FAP 1,24 and in other reports [2][3][4][5][6] did not mention the existence of depressed adenomas, it seems likely that, as confirmed previously in a report on resected colorectum specimens from patients with FAP, 22 the depressed adenoma is a subtype of adenoma that is prone to polypoid growth.…”

Section: Discussionsupporting

confidence: 53%

“…t has been described that duodenal adenomas frequently occur in patients with familial adenomatous polyposis (FAP) [1][2][3][4][5][6] and that these duodenal lesions are prone to malignant transformation. [7][8][9] Although animal experiments have suggested that some specific region within adenomatous polyposis coli gene (Apc) may be related to the development of upper intestinal neoplasia, 10,11 germline mutation within human Apc specific to duodenal neoplasia has yet to be identified.…”

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confidence: 99%

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Depressed adenoma of the duodenum in patients with familial adenomatous polyposis

Matsumoto

Iida

Nakamura

et al. 1999

Cancer

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Section: Discussionsupporting

confidence: 53%

mentioning

confidence: 99%

Depressed adenoma of the duodenum in patients with familial adenomatous polyposis

Matsumoto

Iida

Nakamura

et al. 1999

Cancer

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“…1 FGPs are reported to occur in 12.5 to 84% of patients with FAP, [2][3][4][5][6][7][8][9][10][11][12][13] whereas sporadic FGPs are identified in 0.8 to 1.9% of non-FAP patients undergoing upper gastrointestinal endoscopy. 14,15 In addition to increased prevalence in patients with FAP, FAPassociated FGPs tend to be more numerous, occur at a younger age, and have a more equal gender distribution than sporadic FGPs.…”

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confidence: 99%

Fundic Gland Polyps in Familial Adenomatous Polyposis

Abraham

Nobukawa

Giardiello

et al. 2000

The American Journal of Pathology

202

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“…Duodenum is the second most commonly affected site of polyp development in FAP patients. 1 Duodenal polyps developed in FAP patients are adenomatous polyps, known as pre-cancerous lesions for duodenal adenocarcinoma. 2 While prophylactic proctocolectomy has decreased the proportion of colorectal cancer as a cause of death in FAP patients, duodenal cancer has become a more important cause of death for these patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Gastric and Duodenal Polyps and Risk Factors for Duodenal Neoplasm in Korean Patients with Familial Adenomatous Polyposis

Park¹,

Ryu²,

Park³

et al. 2011

Gut Liver

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Background/Aims: The prevalence of gastric polyps, duodenal adenoma and duodenal cancer has been reported as being high among familial adenomatous polyposis (FAP) patients, but there have been no reports of this association in Korea. This study evaluated the prevalence of gastric and duodenal polyps and risk factors for duodenal neoplasm in FAP patients in Korea. Methods: We reviewed both initial and follow-up endoscopic results from FAP patients. We also investigated the treatment modality of duodenal adenomas and analyzed the risk factors of duodenal neoplasms by logistic regression analysis. Results: A total of 148 patients with FAP underwent esophagogastroduodenoscopy (EGD), and the fi ndings were as follows: gastric polyp 39.9% (fundic gland polyp 25.7% and gastric adenoma 14.2%), duodenal adenoma 15.5%, gastric cancer 2.7%, and duodenal cancer 0.7%. There were two cases of gastric cancer that developed from benign gastric polyps. There were progressions of duodenal adenomatosis during follow-up, and some degree of relapse occurred after endoscopic resection. Patients with gastric polyps showed a correlation with the occurrence of duodenal neoplasm (odds ratio, 2.814; p=0.024). Conclusions: In Korean FAP patients, gastric cancer was detected more frequently, but fundic gland polyps, duodenal adenoma and duodenal cancer were detected less frequently than in Western patients. FAP patients with gastric polyps should undergo regular EGD, particularly for the early detection of duodenal neoplasia. (Gut Liver 2011;5:46-51) Key Words: Familial adenomatous polyposis; Duodenal cancer; Polyps; Adenomas; Gastric cancer INTRODUCTIONFamilial adenomatous polyposis (FAP) is characterized by the presence of at least one-hundred colorectal polyps and an earlyprogression to the colon cancer. Duodenum is the second most commonly affected site of polyp development in FAP patients. 1Duodenal polyps developed in FAP patients are adenomatous polyps, known as pre-cancerous lesions for duodenal adenocarcinoma.2 While prophylactic proctocolectomy has decreased the proportion of colorectal cancer as a cause of death in FAP patients, duodenal cancer has become a more important cause of death for these patients. 3,4 Therefore, endoscopic surveillance is important for the early detection of duodenal cancer and can improve the prognosis of FAP patients. 5The stomach is also known as a common site of polyps in FAP patients. Fundic gland polyps are the most prevalent gastric lesions, followed by adenomatous polyps. 6 In general, gastric cancer arises from adenomatous polyps via the adenomacarcinoma sequence, but several recent reports have shown that gastric adenocarcinoma can be developed from fundic gland polyp in FAP patients. [7][8][9] In this study, we investigated the prevalence of gastric polyps and adenocarcinoma, the changing pattern through follow-up endoscopy and the precancerous possibility of gastric polyp in FAP patients. Also, we described the prevalence of duodenal polyps and adenocarcinoma, progression through follow-up...

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Upper gastrointestinal tract polyps in familial adenomatosis coli.

Cited by 125 publications

References 25 publications

Depressed adenoma of the duodenum in patients with familial adenomatous polyposis

Depressed adenoma of the duodenum in patients with familial adenomatous polyposis

Fundic Gland Polyps in Familial Adenomatous Polyposis

Prevalence of Gastric and Duodenal Polyps and Risk Factors for Duodenal Neoplasm in Korean Patients with Familial Adenomatous Polyposis

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