Upper Genital Tract Changes and Pregnancy Outcome in Offspring Exposed in Utero to Diethylstilbestrol

Kaufman, Raymond H.; Adam, Ervín; Binder, Gary L.; Gerthoffer, Elizabeth

doi:10.1097/00006254-198103000-00015

Cited by 25 publications

(31 citation statements)

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“…In this regard, women exposed in utero to DES exhibit a characteristic spectrum of structural malformations of the Fallopian tube, uterine corpus, and cervix (Kaufman et al, 1977(Kaufman et al, , 1980Haney et al, 1979;DeCherney et al, 1981;Goldstein, 1978;Pillsbury, 1980;Stillman, 1982), all of which can be interpreted as perturbations in the structure, organization, and differentiation of uterine mesenchymal derivatives.…”

Section: Des Dosage (Pg)mentioning

confidence: 99%

“…The teratogenicity of estrogens on the developing uterus is well established both in laboratory animals and humans (Viscomi et al, 1980;Haney et al, 1979;Cunha et al, 1987;Kaufman et al, 1977Kaufman et al, , 1980Forsberg, 1988;Mori and Iguchi, 1988). Immediate effects of estrogens on the developing uterus include qualitative and quantitative changes in protein synthesis (Newbold et al, 1981(Newbold et al, , 1984 and stimulation of epithelial proliferation (Forsberg, 1970;Eide, 1975a,b;Bigsby and Cunha, 1986).…”

Section: Introductionmentioning

confidence: 99%

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Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Brody

Cunha

1989

Am. J. Anat.

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The effects of diethylstilbestrol (DES) treatment on myometrial development from the prenatal to adult period were examined in rats and mice by histologic and immunocytochemical methods using anti-actin, -vimentin, and -laminin to assess cytodifferentiation of smooth muscle and fibroblastic cells, and by morphometric procedures to assess quantitatively the effect of DES on the expression of cellular orientation in the emerging inner circular myometrial layer. Neonatal rats and mice were treated with DES from day 0 (day of birth) to day 2 with dosages known to perturb myometrial development. Neonatal treatment with DES increased the degree of circular orientation within the uterine mesenchyme, an effect detectable following as little as 24 hr of DES treatment. This effect on spatial organization of the mesenchyme was followed by an increase in the thickness of the actin-positive middle layer (prospective circular myometrium) of uterine mesenchyme during days 3-15; from day 15 onward, however, the circular myometrial layer began to fragment into irregular bundles of smooth muscle, and the longitudinal myometrial layer became thinner and more irregularly organized than controls. Vimentin localization in rats treated with DES neonatally was more intense than in controls within the circularly orientated uterine mesenchyme at 5 days. By 60 days the circular and longitudinal myometrial layers of DES-treated animals showed strands and bundles of vimentin-positive cells, which were not present in controls. Both rats and mice show comparable effects of DES treatment.

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Section: Des Dosage (Pg)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Brody

Cunha

1989

Am. J. Anat.

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“…DES is a potent teratogen, and prenatal DES exposure can disrupt the diff erentiation of estrogen target organs, mainly the reproductive organs (2). DES is known to have adverse consequences including clear cell adenocarcinoma of the vagina or cervix and genital tract abnormalities such as transverse cervical and vaginal ridges, vaginal adenosis, and hypoplastic and "T-shaped" uterus (3). Many studies have demonstrated that DES daughters also have poor reproductive histories and commonly experience infertility, premature delivery, and recurrent abortions.…”

Section: Discussionmentioning

confidence: 99%

Management of Pelvic Floor Disorder in a Diethylstilbestrol Daughter

Chung¹,

Cao²,

Wakabayashi³

et al. 2017

Baylor University Medical Center Proceedings

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“…Clear cell adenocarcinoma of the vagina in the daughters of the women who were treated with DES during pregnancy was the adverse outcome that revealed the danger of DES [Herbst et al, 1971]. Other abnormalities included uterine deformities, vaginal adenosis, annular rings, transverse ridges, cockscomb deformity of the anterior lip, extensive ectropion, and vaginal hypoplasia [Siegler et al, 1979;Kaufman et al, 1980], which were very common (up to 90%) in contrast to the rare occurrence of cancer (1.4-14 per 10,000). Very similar findings can be found in experimental an-imals that are exposed to DES in utero [McLachlan, 2001;Newbold, 2001].…”

Section: Effects Of Estrogensmentioning

confidence: 99%

Environmental Endocrine Disrupters

Toppari¹

2008

Sex Dev

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Androgens, anti-Müllerian hormone, and insulin-like factor 3 are testis-derived hormones that regulate male sexual differentiation. Correct timing of secretion and action of these hormones is critical for normal development. Endocrine disrupters are exogenous substances that cause adverse effects in the endocrine system. They can impair the synthesis, distribution, metabolism, excretion, and action of hormones. Male sexual differentiation can be disrupted by antiandrogens and synthetic estrogens such as diethylstilbestrol. The number of identified environmental antiandrogens keeps growing and these compounds show clear dose-additive effects causing worry that a mixture of these chemicals can cause adverse effects even when each compound is present at a low concentration. This is also a demanding research task for endocrinologists working with disorders of sex differentiation.

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Upper Genital Tract Changes and Pregnancy Outcome in Offspring Exposed in Utero to Diethylstilbestrol

Cited by 25 publications

References 0 publications

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Histologic, morphometric, and immunocytochemical analysis of myometrial development in rats and mice: II. Effects of DES on development

Management of Pelvic Floor Disorder in a Diethylstilbestrol Daughter

Environmental Endocrine Disrupters

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