Upper Tract Urothelial Recurrence Following Radical Cystectomy for Transitional Cell Carcinoma of the Bladder: An Analysis of 1,069 Patients With 10-Year Followup

Sanderson, Kristin M.; Cai, Jie; Miranda, Gara; Skinner, Donald G.; Stein, John P.

doi:10.1016/j.juro.2007.01.133

Cited by 135 publications

(117 citation statements)

References 16 publications

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“…Similarly, upper tract recurrence has been shown to occur in 2–7% of patients after cystectomy for UC [8,9]. Our data are consistent with these percentages.…”

Section: Discussionsupporting

confidence: 91%

The Clinicopathologic Correlates of Cellular Atypia in Urinary Cytology of Ileal Neobladders

Cimino‐Mathews

Ali²

2011

Acta Cytologica

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Objective: Ileal neobladders (INBs) are routinely created in patients following cystectomy for urothelial carcinoma (UC). Patients are screened by urinary cytology for tumor recurrence. However, the diagnosis of urothelial atypia remains a nonstandardized category in INB specimens and has never been studied before. Study Design: The cytopathology archives from the Johns Hopkins Hospital were searched over a period of 19 years for specimens from patients with INB and atypical urine cytology. Follow-up surgical pathology results and clinical data were reviewed. Results: A total of 620 urine specimens were identified from patients with INB, 77 of which (12.4%) were diagnosed as ‘atypical’. Of the 51 patients who were followed up, only 3 developed a concordant local recurrence (5.9% positive predictive value), defined as biopsy-proven recurrence within 1 year of atypical cytology. The recurrent patients had more diagnoses of ‘atypical cells suspicious for carcinoma’ than nonrecurrent patients (66 vs. 11.4%; p > 0.10). Conclusion: A diagnosis of urothelial atypia in patients with INB is made as frequently as in patients with native bladders but with a lower positive predictive value (5.9 vs. 12%) for subsequent histologic diagnosis of UC. This suggests that the diagnosis of urothelial atypia in INB may have less clinical significance than in native bladders.

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“…Similarly, upper tract recurrence has been shown to occur in 2–7% of patients after cystectomy for UC [8,9]. Our data are consistent with these percentages.…”

Section: Discussionsupporting

confidence: 91%

The Clinicopathologic Correlates of Cellular Atypia in Urinary Cytology of Ileal Neobladders

Cimino‐Mathews

Ali²

2011

Acta Cytologica

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“…132 Staging studies are recommended if there is invasion into ducts, acini, or stroma, as it may alter the prognosis and management. [133][134][135][136] B. Recommendations for management i.…”

Section: Discussionmentioning

confidence: 99%

Recommendations for the improvement of bladder cancer quality of care in Canada: A consensus document reviewed and endorsed by Bladder Cancer Canada (BCC), Canadian Urologic Oncology Group (CUOG), and Canadian Urological Association (CUA), December 2015

Kassouf

Aprikian

Black

et al. 2016

CUAJ

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This initiative was undertaken in response to concerns regarding the variation in management and in outcomes of patients with bladder cancer throughout centres and geographical areas in Canada. Population-based data have also revealed that real-life survival is lower than expected based on data from clinical trials and/or academic centres. To address these perceived shortcomings and attempt to streamline and unify treatment approaches to bladder cancer in Canada, a multidisciplinary panel of expert clinicians was convened last fall for a two-day working group consensus meeting. The panelists included urologic oncologists, medical oncologists, radiation oncologists, patient representatives, a genitourinary pathologist, and an enterostomal therapy nurse. The following recommendations and summaries of supporting evidence represent the results of the presentations, debates, and discussions. Methodology

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“…Risk factors for upper urinary tract recurrence have been established as: history of diffuse CIS, multifocal tumour, intramural ureteral involvement with CIS, prior ureteral tumour, prostatic involvement and urethral involvement. [4][5][6][7] The ureteral FS does not appear to add any independent predictive ability over these established factors for future upper urinary tract recurrences. In addition, with its low positive predictive value, FS has a tendency to overestimate disease at the ureteral margin.…”

Section: Discussionmentioning

confidence: 87%

Ureteral frozen sections at the time of radical cystectomy: reliability and clinical implications

Touma

Izawa

Abdelhady

et al. 2013

CUAJ

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Upper Tract Urothelial Recurrence Following Radical Cystectomy for Transitional Cell Carcinoma of the Bladder: An Analysis of 1,069 Patients With 10-Year Followup

Cited by 135 publications

References 16 publications

The Clinicopathologic Correlates of Cellular Atypia in Urinary Cytology of Ileal Neobladders

The Clinicopathologic Correlates of Cellular Atypia in Urinary Cytology of Ileal Neobladders

Recommendations for the improvement of bladder cancer quality of care in Canada: A consensus document reviewed and endorsed by Bladder Cancer Canada (BCC), Canadian Urologic Oncology Group (CUOG), and Canadian Urological Association (CUA), December 2015

Ureteral frozen sections at the time of radical cystectomy: reliability and clinical implications

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