Upper urinary tract carcinomas: histological types and unusual morphological variants

Montiel, Delia Pérez; Suster, Saul

doi:10.1016/j.mpdhp.2007.11.006

Cited by 10 publications

(3 citation statements)

References 40 publications

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“…Its distinction from clear cell adenocarcinoma is usually without difficulty. The clear cell sub-var-iant is, however, difficult to identify in poorly differentiated carcinoma of the upper tract (renal pelvis/ upper ureter) and to distinguish from high grade clear cell renal cell carcinoma [55,56]. An objective approach for distinguishing the two histological variants would be particularly useful.…”

Section: Clear Cell Sub-variantmentioning

confidence: 99%

FTIR microspectroscopy of selected rare diverse sub‐variants of carcinoma of the urinary bladder

Hughes

Iqbal-Wahid

Brown

et al. 2012

Journal of Biophotonics

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Urothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations.

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Section: Clear Cell Sub-variantmentioning

confidence: 99%

FTIR microspectroscopy of selected rare diverse sub‐variants of carcinoma of the urinary bladder

Hughes

Iqbal-Wahid

Brown

et al. 2012

Journal of Biophotonics

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“…The incidence of UTUC is approximately 2 cases per 100,000 person-years, which has increased slightly over the past 3 decades [1]. Pure UC accounts for most of the UTUCs; however, UTUC with concomitant variant histology (CVH) owing to aberrant histological differentiation is a phenomenon that is well recognized by pathologists [2][3][4] and is similar to UC of the bladder [5]. Because of the rarity of UTUC, few studies have examined the influence of CVH on the prognosis of patients with UTUC treated with radical nephroureterectomy (RNU); the studies that have attempted to assess this have resulted in indefinite conclusions because of small sample sizes and methods of analyses [3,6].…”

Section: Introductionmentioning

confidence: 99%

Effect of concomitant variant histology on the prognosis of patients with upper urinary tract urothelial carcinoma after radical nephroureterectomy

Yan

Song

Wang

et al. 2015

Urologic Oncology: Seminars and Original Investigations

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“…Variant urothelial carcinoma also appears to be a pathological feature associated with high risk UTUC and should therefore be emphasized on pathological reports and during multidisciplinary discussions for patient care management. Similarly to BC, it will/can change management significantly ( 82 ).…”

Section: Evidence Synthesismentioning

confidence: 99%

Predictive models and prognostic factors for upper tract urothelial carcinoma: a comprehensive review of the literature

Mbeutcha

Mathiéu

Rouprêt

et al. 2016

Transl. Androl. Urol.

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In the context of customized patient care for upper tract urothelial carcinoma (UTUC), decision-making could be facilitated by risk assessment and prediction tools. The aim of this study was to provide a critical overview of existing predictive models and to review emerging promising prognostic factors for UTUC. A literature search of articles published in English from January 2000 to June 2016 was performed using PubMed. Studies on risk group stratification models and predictive tools in UTUC were selected, together with studies on predictive factors and biomarkers associated with advanced-stage UTUC and oncological outcomes after surgery. Various predictive tools have been described for advanced-stage UTUC assessment, disease recurrence and cancer-specific survival (CSS). Most of these models are based on well-established prognostic factors such as tumor stage, grade and lymph node (LN) metastasis, but some also integrate newly described prognostic factors and biomarkers. These new prediction tools seem to reach a high level of accuracy, but they lack external validation and decision-making analysis. The combinations of patient-, pathology- and surgery-related factors together with novel biomarkers have led to promising predictive tools for oncological outcomes in UTUC. However, external validation of these predictive models is a prerequisite before their introduction into daily practice. New models predicting response to therapy are urgently needed to allow accurate and safe individualized management in this heterogeneous disease.

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Upper urinary tract carcinomas: histological types and unusual morphological variants

Cited by 10 publications

References 40 publications

FTIR microspectroscopy of selected rare diverse sub‐variants of carcinoma of the urinary bladder

FTIR microspectroscopy of selected rare diverse sub‐variants of carcinoma of the urinary bladder

Effect of concomitant variant histology on the prognosis of patients with upper urinary tract urothelial carcinoma after radical nephroureterectomy

Predictive models and prognostic factors for upper tract urothelial carcinoma: a comprehensive review of the literature

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