Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis

Shu, Qingyang; Yang, Guanteng; Tang, Ming-Xing; Guo, Chaofeng; Zhang, Hongqi; Li, Jiong

doi:10.1016/j.bbrc.2023.02.034

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…This could be because neurofibromin, which is non‐functional in NF1 patients, acts as an oestrogen receptor co‐repressor 14 . Oestrogen receptor activation in the paraspinal muscles has been thought to decrease muscle strength and increase muscle flexibility, leading to a lack of muscular support for the spine and an increased susceptibility to scoliosis 15 . Thus, without neurofibromin's repressible activity on the oestrogen receptor, there could be unregulated activation of the oestrogen receptor leading to increased likelihood and progression of scoliosis in female NF1 patients.…”

Section: Discussionmentioning

confidence: 99%

“…14 Oestrogen receptor activation in the paraspinal muscles has been thought to decrease muscle strength and increase muscle flexibility, leading to a lack of muscular support for the spine and an increased susceptibility to scoliosis. 15 Thus, without neurofibromin's repressible activity on the oestrogen receptor, there could be unregulated activation of the oestrogen receptor leading to increased likelihood and progression of scoliosis in female NF1 patients. Among all the comorbidities analysed, lymphomas were the most likely comorbidity to occur (OR: 271.377) in NF1 patients with scoliosis (Table 4).…”

Section: Discussionmentioning

confidence: 99%

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The role of scoliosis on the comorbidity and demographics of neurofibromatosis type 1 patients: A retrospective analysis of the National Inpatient Sample database

Kodali,

Kumar,

Schwartz

2023

Experimental Dermatology

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Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome in the United States, affecting every 1 in 3000 individuals. NF1 occurs due to non‐functional mutations in the NF1 gene, which expresses neurofibromin, a protein involved in tumour suppression. As a result, NF1 typically presents with non‐cancerous neoplasm masses called neurofibromas across the body. Out of all NF1 abnormalities, the most common skeletal abnormality seen in around 10%–30% of NF1 patients is scoliosis, an improver curvature of the spine. However, there is a lack of research on the effects of scoliosis on demographics and morbidities of NF1 patients. We performed a national analysis to investigate the complex relationship between NF1 and scoliosis on patients' demographics and comorbidities. We conducted a retrospective cross‐sectional analysis of the 2017 US National Inpatient Sample database using univariable Chi‐square analysis and multivariable binary logistic regression analysis to determine the interplay of NF1 and scoliosis on patients' demographics and comorbidities. Our query resulted in 4635 total NF1 patients, of which 475 (10.25%) had scoliosis and 4160 (89.75%) did not. Demographic analysis showed that NF1 patients with scoliosis were typically younger, female and white compared to NF1 patients without scoliosis. Comorbidity analysis showed that NF1 patients with scoliosis were more likely to develop malignant brain neoplasms, epilepsy, hydrocephalus, pigmentation disorders, hypothyroidism, diabetes with chronic complications and coagulopathy disorders. NF1 patients with scoliosis were less likely to develop congestive heart failure, pulmonary circulation disease, peripheral vascular disease, paralysis, chronic pulmonary disease, lymphoma and psychosis. NF1 patients with scoliosis were predominantly younger, female, white patients. The presence of scoliosis in NF1 patients increases the risks for certain brain neoplasms and disorders but serves a protective effect against some pulmonary and cardiac complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of scoliosis on the comorbidity and demographics of neurofibromatosis type 1 patients: A retrospective analysis of the National Inpatient Sample database

Kodali,

Kumar,

Schwartz

2023

Experimental Dermatology

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show abstract

“…14 Estrogen receptor activation in the paraspinal muscles has been thought to decrease muscle strength and increase muscle exibility, leading to a lack of muscular support for the spine and an increased susceptibility for scoliosis. 15 Thus, without neuro bromin's repressible activity on the estrogen receptor, there could be unregulated activation of the estrogen receptor leading to increased likelihood and progression of scoliosis in female NF1 patients. Among all the comorbidities analyzed, lymphomas were the most likely comorbidity to occur (OR: 271.377) in NF1 patients with scoliosis (Table IV).…”

Section: Discussionmentioning

confidence: 99%

The Role of Scoliosis on the Comorbidity and Demographics of Neurofibromatosis Type-1 Patients: A Retrospective Analysis of the National Inpatient Sample Database

Kodali

Kumar

Schwartz

2023

Preprint

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Background Neurofibromatosis type 1 (NF1) is the most common neurocutaneous syndrome in the United States, affecting every 1 in 3000 individuals. NF1 occurs due to non-functional mutations in the NF1 gene, which expresses neurofibromin, a protein involved in tumor suppression. As a result, NF1 typically presents with non-cancerous neoplasm masses called neurofibromas across the body. The most common musculoskeletal abnormality seen in around two-third of NF1 patients is scoliosis, an improver curvature of the spine. However, there is a lack of research on the effects of scoliosis on demographics and morbidities of NF1 patients. Objective We performed a national analysis to investigate the complex relationship between NF1 and scoliosis on patients’ demographics and comorbidities. Method We conducted a retrospective cross-sectional analysis of the 2017 US National Inpatient Sample database using univariable Chi-square analysis and multivariable binary logistic regression analysis to determine the interplay of NF1 and scoliosis on patients’ demographics and comorbidities. Results Our query resulted in 4,635 total NF1 patients, of which 475 (10.25%) had scoliosis and 4,160 (89.75%) did not. Demographic analysis showed that NF1 patients with scoliosis were typically younger, female, and white than when compared to NF1 patients without scoliosis. Comorbidity analysis showed that NF1 patients with scoliosis were more likely to develop malignant brain neoplasms, epilepsy, hydrocephalus, pigmentation disorders, hypothyroidism, diabetes with chronic complications, and coagulopathy disorders. NF1 patients with scoliosis were less likely to develop congestive heart failure, pulmonary circulation disease, peripheral vascular disease, paralysis, chronic pulmonary disease, lymphoma, and psychosis. Conclusion NF1 patients with scoliosis were predominantly younger, female, white patients. The presence of scoliosis in NF1 patients increases the risks for certain brain neoplasms and disorders, but serves a protective effect against some pulmonary and cardiac complications.

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Menstrual cycle phase differences in myofiber damage and macrophage infiltration following electrical stimulation-induced muscle injury

Pfeifer,

King,

Ahmadi

et al. 2024

American Journal of Physiology-Endocrinology and Metabolism

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The menstrual cycle has widespread physiological effects across many systems, including skeletal muscle. In this study, we show that women in the late follicular phase of the menstrual cycle may be more susceptible to myofiber necrosis following electrical stimulation. We also show reduced evidence of inflammation in the late follicular phase. This is the first study to demonstrate a difference in the response of human skeletal muscle to a necrotic stimulus across a menstrual cycle.

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Upregulated estrogen receptors impairs myogenesis and elevates adipogenesis related factor levels in the paravertebral muscles of patients with idiopathic scoliosis

Cited by 4 publications

References 29 publications

The role of scoliosis on the comorbidity and demographics of neurofibromatosis type 1 patients: A retrospective analysis of the National Inpatient Sample database

The role of scoliosis on the comorbidity and demographics of neurofibromatosis type 1 patients: A retrospective analysis of the National Inpatient Sample database

The Role of Scoliosis on the Comorbidity and Demographics of Neurofibromatosis Type-1 Patients: A Retrospective Analysis of the National Inpatient Sample Database

Menstrual cycle phase differences in myofiber damage and macrophage infiltration following electrical stimulation-induced muscle injury

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