Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis

Abstract

Introduction: Acute cerebral ischemic stroke (AIS) dramatically influences patients' quality of life. lncRNA NORAD (NORAD) has been studied in cerebrovascular diseases, which are potential risk factors for AIS. The specific significance of NORAD is unclear. This study aimed to assess the role of NORAD in AIS, and to provide therapeutic value for its' treatment. Material and methods: A total of 103 AIS patients and 95 healthy individuals (control) were enrolled into this study. Expression level of NORAD in the plasma of all participants was analyzed by PCR. Diagnostic potential of NORAD in AIS was evaluated by ROC analysis, while Kaplan-Meier and Cox regression analyses were conducted to assess its' prognostic value in AIS.Results: A significantly increased level of NORAD was observed in AIS patients compared with healthy individuals. The upregulation of NORAD could dramatically discriminate AIS patients from healthy individuals with high sensitivity (81.60%) and specificity (88.40%). NORAD was positively correlated with patients' high-sensitivity C-reactive protein (hs CRP, r = 0.796), matrix metalloproteinase-9 (MMP9, r = 0.757), and NIHSS scores (r = 0.840), and negatively related to pc-ASPECTS scores (r = -0.607). Moreover, NORAD upregulation was associated with patients' unfavorable prognosis and served as an independent prognostic biomarker, together with NIHSS and pc-ASPECTS scores of AIS patients. Conclusions: NORAD was upregulated in AIS, which can discriminate AIS patients, and was closely correlated with severe development and poor prognosis of patients.

NORAD-Regulated Signaling Pathways in Breast Cancer Progression

“…Due to NORAD's extensive network of binding partners, it has been associated with different pathological conditions including cardiovascular, cerebrovascular and degenerative diseases [15][16][17], but mostly with cancer [1]. Studies suggest that NORAD is dysregulated in numerous cancers, including breast, renal, gastric, bladder, pancreatic, ovarian, cervical, prostate, lung and endometrial cancer [18].…”