2012
DOI: 10.2337/db12-0420
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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Abstract: Despite the recent attention focused on the roles of the nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in the pathogenesis of type 2 diabetes, little is known about the ex vivo profile of inflammasome activation in type 2 diabetic patients. In this study, we investigated patterns of NLRP3 inflammasome activation in monocyte-derived macrophages (MDMs) from drug-naïve patients with newly diagnosed type 2 diabetes. Type 2 diabetic subjects had si… Show more

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Cited by 635 publications
(518 citation statements)
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“…This study is the first to compare NLRP3 inflammasome activity involved in obesity-induced inflammation and insulin resistance [29][30][31][32] and the composition of the SVCs in paired SAT and VAT samples taken from obese patients with or without the metabolic syndrome. We describe significant differences in the inflammatory profile of VAT from MUO patients compared with that from MHO patients.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…This study is the first to compare NLRP3 inflammasome activity involved in obesity-induced inflammation and insulin resistance [29][30][31][32] and the composition of the SVCs in paired SAT and VAT samples taken from obese patients with or without the metabolic syndrome. We describe significant differences in the inflammatory profile of VAT from MUO patients compared with that from MHO patients.…”
Section: Discussionmentioning
confidence: 99%
“…When activated, NLRP3 forms a complex with its adaptor molecule ASC, which in turn promotes the recruitment of pro-caspase 1 and its cleavage into active caspase-1 [28]. Compelling evidence shows that the NLRP3 inflammasome has a central role in obesity-induced inflammation and insulin resistance via these mechanisms [29][30][31].…”
Section: Introductionmentioning
confidence: 99%
“…Hyperglycaemia and hyperlipidaemia are stimulators of inflammasomes [8,33], and the finding that patients with type 2 diabetes have activated inflammasomes in myeloid cells [34] is intriguing. However, this study was based on a comparison of newly diagnosed diabetes patients and controls with mean HbA 1c levels of 8.5% and 5.0%, respectively.…”
Section: Associations Between Immunological Variables and Deterioratimentioning
confidence: 99%
“…[15][16][17] Of note, a mechanistic relevance of inflammasome activation in animal models of dNP has recently been established. 3 Furthermore, a recent observational study suggests that inhibition of inflammasome signaling improves renal function (on the basis of a decline in serum creatinine) in patients with established dNP.…”
mentioning
confidence: 99%