Upregulated serum miR‐128‐3p in progressive and relapse‐free multiple sclerosis patients

Abstract

Multiple sclerosis (MS) is a complex immune-mediated disease of the CNS showing remarkable pathological and clinical heterogeneity among cases. In a personalized medicine era, there is an unmet need of biomarkers for MS that could distinct disease subtypes and predict the clinical course at the individual patient level early after onset. MicroRNAs are small non-coding RNAs that regulate the expression of genes at post-transcriptional level by targeting messenger RNA for translational repression or degradation. 1 Altered expression of microRNAs has been observed in a number of pathological conditions, including MS, suggesting a key role in immune system regulation, differentiation of T and B cells, proliferation of monocytes and neutrophils, and expression of cytokines and chemokines. 2 Circulating microRNAs are present in several body fluids, including serum, where they are exceptionally stable, making them potential candidates for clinical application in MS. Levels of various circulating microRNAs were found to be associated to MS diagnosis, clinical subtypes, disease severity, and disability progression. 3-9 Aim of this study was to investigate the association between candidate microRNA expression in serum samples of patients with MS and the disease course.

Changes in Exosomal miRNA Composition in Thyroid Cancer Cells after Prolonged Exposure to Real Microgravity in Space

“…Cleaved from the stem-loop hsa-miR-128-2, miR-128-3p is the main mature strand with reports in more than 150 published experiments. It has been described—besides cancer—in various diseases physiological processes, such as rheumatoid arthritis, multiple sclerosis, atrial fibrosis, and vascular disease, response to sepsis and acute kidney injury, osteogenesis and bone healing, to name a few [ 124 , 125 , 126 , 127 , 128 , 129 ]. Mets et al reported miR-128-3p as a candidate for an oncomiR in T-cell acute lymphoblastic leukemia as it downregulates PHF6, which plays an important tumor-suppressive role in this disorder.…”

MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases

“…miR-873, which promotes NF-κB activation and increases inflammatory factors such as IL-6, macrophage inflammatory protein-1, and monocyte chemotactic protein -2, was upregulated in astrocytes from EAE mice [134]. Other dysregulated miRNAs, such as the downregulated miRNA-467b, miR-146a, and miR-219-5p [132,133,138,139,[141][142][143][144][145][146][147][148][149][150][151][152][153][154][155][156][157][158], or the altered regulation of miR-223 were proposed to participate in MS pathology and have potential therapeutic application [132,[138][139][140]150].…”

The cytoprotective role of omentin against oxidative stress-induced PC12 apoptosis

“…Extensive studies have reported the regulatory role of miR-128-3p during the pathogenesis of a variety of human diseases, such as Parkinson's disease, myocardial inflammation, multiple sclerosis, and liver ischaemia-reperfusion injury [39][40][41][42] etc. Mao et al found that increased miR-128-3p level could reduce the protein level of p38a thus inhibit the activation of pro-apoptotic pathway and prevent neuronal death during cerebral ischaemia in mice [43].…”