Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers

Baek, Kyoung Eun; Yoon, Suk Ran; Kim, Jong-Tae; Kim, Kwang S.; Kang, Seong Ho; Yang, Young; Lim, Jong‐Seok; Choi, Inpyo; Nam, Myoung Soo; Yoon, Michung; Lee, Hee Gu

doi:10.1016/j.cca.2008.12.008

Cited by 39 publications

(34 citation statements)

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“…Regarding GC, the overexpression and exposure to exogenous GDF15 has been involved in the activation of different proliferative and invasive signals in tumor cell lines [29,30], whereas the GDF15 expression in primary tumors was correlated with progressive pathological parameters [31]. Finally, GDF15 levels were detected significantly increased in serum and plasma from GC patients versus healthy controls [32,33]. Increased GDF15 plasma levels were associated with poor survival in a pool of esophageal and GC patients including different histological subtypes, although without achieving prognostic independence [33].…”

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confidence: 87%

Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer

et al. 2014

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confidence: 87%

Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer

et al. 2014

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“…4, 65,66 Despite that the GDF-15 expression profile has been well described in various cancers, its specific role in tumor development remains unclear (Figure 1). For example, in breast or gastric cancer, GDF-15 has been shown to be upregulated upon the activation of the MAPK-ERK1/2 or PKB/Akt pathways recruiting the SP-1 family of transcription factors.…”

Section: Gdf-15 In Cancer Progression Systemic and Immune Responsementioning

confidence: 99%

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Vaňhara

Hampl

Kozubı́k

et al. 2012

Prostate Cancer Prostatic Dis

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Deregulation of expression and function of cytokines belonging to the transforming growth factor-b (TGF-b) family is often associated with various pathologies. For example, this cytokine family has been considered a promising target for cancer therapy. However, the detailed functions of several cytokines from the TGF-b family that could have a role in cancer progression and therapy remain unclear. One of these molecules is growth/differentiation factor-15 (GDF-15), a divergent member of the TGF-b family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with cancer progression, including prostate cancer (PCa). However, studies clearly demonstrating the mechanisms for signal transduction and functions in cell interaction, cancer progression and therapy are still lacking. New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for PCa bone metastases. Moreover, GDF-15 is as an abundant cytokine in seminal plasma with immunosuppressive properties. We discuss studies that focus on the regulation of GDF-15 expression and its role in tissue homeostasis, repair and the immune response with an emphasis on the role in PCa development.

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“…MIC-1 is overexpressed by malignant melanoma cells and is associated with tumourigenicity (Boyle et al, 2009). High serum concentrations of MIC-1 have been observed in patients with pancreatic (Koopmann et al, 2004(Koopmann et al, , 2006, gastric (Baek et al, 2009), and breast cancer (Welsh et al, 2003), and have been associated with adverse survival in colorectal cancer and glioblastoma (Shnaper et al, 2009). In prostate cancer, high patient serum levels of MIC-1 have been associated with increased disease stage (Selander et al, 2007), docetaxel resistance (Zhao et al, 2009), and adverse survival .…”

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Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

et al. 2010

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BACKGROUND: Macrophage inhibitory cytokine-1(MIC-1) is a potential modulator of systemic inflammation and nutritional depletion, both of which are adverse prognostic factors in oesophago-gastric cancer (OGC). METHODS: Plasma MIC-1, systemic inflammation (defined as plasma C-reactive protein (CRP) of X10 mg l -1 or modified Glasgow prognostic score (mGPS) of X1), and nutritional status were assessed in newly diagnosed OGC patients (n ¼ 293). Healthy volunteers (n ¼ 35) served as controls. RESULTS: MIC-1 was elevated in patients (median ¼ 1371 pg ml -1 ; range 141 -39 053) when compared with controls (median ¼ 377 pg ml -1 ; range 141 -3786; Po0.001). Patients with gastric tumours (median ¼ 1592 pg ml -1 ; range 141 -12 643) showed higher MIC-1 concentrations than patients with junctional (median ¼ 1337 pg ml -1 ; range 383 -39 053) and oesophageal tumours (median ¼ 1180 pg ml -1 ; range 258 -31 184; P ¼ 0.015). Patients showed a median weight loss of 6.4% (range 0.0 -33.4%), and 42% of patients had an mGPS of X1 or plasma CRP of X10 mg l -1 (median ¼ 9 mg l -1 ; range 1 -200). MIC-1 correlated positively with disease stage (r 2 ¼ 0.217; Po0.001), age (r 2 ¼ 0.332; Po0.001), CRP (r 2 ¼ 0.314; Po0.001), and mGPS (r 2 ¼ 0.336; Po0.001), and negatively with Karnofsky Performance Score (r 2 ¼ À0.269; Po0.001). However, although MIC-1 correlated weakly with dietary intake (r 2 ¼ 0.157; P ¼ 0.031), it did not correlate with weight loss, BMI, or anthropometry. Patients with MIC-1 levels in the upper quartile showed reduced survival (median ¼ 204 days; 95% CI 157 -251) when compared with patients with MIC-1 levels in the lower three quartiles (median ¼ 316 days; 95% CI 259 -373; P ¼ 0.036), but MIC-1 was not an independent prognostic indicator. CONCLUSIONS: There is no independent link between plasma MIC-1 levels and depleted nutritional status or survival in OGC.

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Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers

Cited by 39 publications

References 20 publications

Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer

Circulating Levels of GDF15, MMP7 and miR-200c as a Poor Prognostic Signature in Gastric Cancer

Growth/differentiation factor-15: prostate cancer suppressor or promoter?

Plasma MIC-1 correlates with systemic inflammation but is not an independent determinant of nutritional status or survival in oesophago-gastric cancer

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