Upregulation Mitochondrial Carrier 1 (MTCH1) Is Associated with Cell Proliferation, Invasion, and Migration of Liver Hepatocellular Carcinoma

Abstract

Among the primary causes of cancer-associated death in the world, liver hepatocellular carcinoma (LIHC) ranks the third. LIHC is defined as the sixth most frequently diagnosed carcinoma. The gene mitochondrial carrier 1 (MTCH1) is a protein-coding gene. Recent research suggests that MTCH1 may be associated with some diseases. Here, our study attempts to explore the role and implication of MTCH1 in LIHC. Kaplan Meier Plotter and GEPIA (Gene Expression Profiling Interactive Analysis) databases were employed to determine the expression of MTCH1 and its correlation with prognostic status in LIHC patients. For the first time, our results suggested that MTCH1 was aberrantly expressed in human pan-cancer and highly expressed in LIHC. Its high expression was closely associated with metastasis of tumor, stage of cancer, and poor survival of patients. Then, through enrichment analysis, MTCH1 was found to be closely related to RNA splicing in LIHC. Subsequently, we conducted a series of functional experiments. PCR data showed that LIHC cell lines and samples are highly expressed MTCH1. CCK-8 (Cell Counting Kit-8) assays and Transwell assays indicated that silencing MTCH1 certainly suppressed cell proliferation, migration, and invasion. These findings shed the clue that MTCH1 could be regarded as the potential prognosis biomarker of LIHC and a promising therapeutic target for LIHC.

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

“…MRPL17 was identi ed as a crucial factor in oral carcinogenesis in an analysis of patients with tongue cancer (36). MTCH1 upregulation was associated with cell proliferation in hepatocellular carcinoma (37). The increasing presentation of MTCH1 neoantigen after ionizing radiation has also been noted (38).…”

Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells

“…We have shown that MTCH2 overexpression in human gastric cancer tissues is related to invasion, metastasis, and survival rate, reflecting the clinical value of MTCH2 in the diagnosis and treatment of gastric cancer. In cancer research, the upregulation of MTCH1 has been observed to promote hepatocellular carcinoma cell proliferation, invasion, and migration[ 23 ]. Through the search of GEPIA database, MTCH2 is more valuable than MTCH1 in the study of gastric adenocarcinoma.…”

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

“…MRPL17 has been implicated as crucial player in oral carcinogenesis from analysis in patients with tongue cancer [36]. Upregulation of MTCH1 is associated with cell proliferation of liver hepatocellular carcinoma [37]. The increasing presentation of MTCH1 neoantigen after ionizing radiation was also noted [38].…”