Upregulation of angiostatic chemokines IP-10/CXCL10 and I-TAC/CXCL11 in human obesity and their implication for adipose tissue angiogenesis

Hueso, Luisa; Ortega, Rebeca; Selles, Francisca; Wu-Xiong, Ning Yun; Civera, Miguel; Ascaso, Juan F.; Sanz, María-Jesús; Real, José T.; Piqueras, Laura

doi:10.1038/s41366-018-0102-5

Cited by 52 publications

(36 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in line with observations that these chemokines compromise endothelial integrity via CXCR3 17 , and that CXCL10 is a key determinant of severe COVID-19 18 . Interestingly, basal levels of CXCL9 or CXCL10 are elevated in elderly, hypertensive, and obese individuals, who were strongly represented in our autopsy cohort (Table 1 and Supplementary Table 1) and are predisposed to severe COVID-19 19,20 .…”

Section: Resultsmentioning

confidence: 91%

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Nienhold¹,

et al. 2020

View full text Add to dashboard Cite

Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. Immune mediated damage has been proposed as a pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles of post mortem COVID-19 (n = 34 tissues from 16 patients) and normal lung tissues (n = 9 tissues from 6 patients). Two distinct immunopathological reaction patterns of lethal COVID-19 are identified. One pattern shows high local expression of interferon stimulated genes (ISGhigh) and cytokines, high viral loads and limited pulmonary damage, the other pattern shows severely damaged lungs, low ISGs (ISGlow), low viral loads and abundant infiltrating activated CD8+ T cells and macrophages. ISGhigh patients die significantly earlier after hospitalization than ISGlow patients. Our study may point to distinct stages of progression of COVID-19 lung disease and highlights the need for peripheral blood biomarkers that inform about patient lung status and guide treatment.

show abstract

Section: Resultsmentioning

confidence: 91%

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Nienhold¹,

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This is in line with observations that these chemokines compromise endothelial integrity via CXCR3 16 , and that CXCL10 is a key determinant of severe COVID-19 17 . Interestingly, basal levels of CXCL9 or CXCL10 are elevated in elderly, hypertensive and obese individuals, who were strongly represented in our autopsy cohort ( Table 1) and are predisposed to severe COVID-19 18,19 .…”

Section: The Isg High and Isg Low Lung Immunoprofiles Correlate Withmentioning

confidence: 86%

Two distinct immunopathological profiles in autopsy lungs of COVID-19

Nienhold¹,

Ciani

Koelzer

et al. 2020

Preprint

147

View full text Add to dashboard Cite

Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. Distinct patterns of pulmonary COVID-19 immune responses correlated to hospitalization time and may guide treatment and vaccination approaches.

show abstract

“…This is in line with observations that these chemokines compromise endothelial integrity via CXCR3 9 , and that CXCL10 is a key determinant of severe COVID-19 10 . Interestingly, basal levels of CXCL9 or CXCL10 are elevated in elderly, hypertensive and obese individuals, which were strongly represented in our autopsy cohort and are predisposed to severe COVID-19 11,12 . Of note, our study could not take extrapulmonary cytokine sources or effects into account.…”

Section: Main Textmentioning

confidence: 78%