Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue

Linderone Isolated from Lindera erythrocarpa Exerts Antioxidant and Anti-Neuroinflammatory Effects via NF-κB and Nrf2 Pathways in BV2 and HT22 Cells

“…The Nrf-2/HO-1 pathway is crucial in neuroprotective strategies [36]. The activation of HO-1 can protect neurons from oxidative damage [37]. Our results indicate that indenone induces HO-1 expression in both BV2 and HT22 cells (Figure 6A,B).…”

Mechanical active compression-decompression versus standard mechanical cardiopulmonary resuscitation: A randomised haemodynamic out-of-hospital cardiac arrest study

“…Moreover, drugs with potent anti-oxidising capacities like methylene blue and inhaled 2% H2-gas has shown a clear effect on survival and especially seems to protect vulnerable brain tissues in animal models of prolonged cardiac arrest. [170,174,190,191] These findings represent the first important breakthroughs in the search for pharmacological strategies to improve survival through the Metabolic phase.…”

Tidal volume measurements via transthoracic impedance waveform characteristics: The effect of age, body mass index and gender. A single centre interventional study

“…This continued overproduction leads to massive and uncontrolled chemical reactions that are almost uniformly related to cell death inducing processes. [173,174] However, in witnessed SCA cases with rapid start of CPR, the brain will receive oxygen, and its favoured nutrients glucose, lactate and to some degree ketones, in CPR quality dependent doses. This can fuel the transition into the HIF-1𝛼 induced, protective, hibernation-like state.…”