Upregulation of ITGAV and the underlying mechanisms in nasopharyngeal carcinoma

Huang, Si-Wei; Luo, Jia‐Yuan; Qin, Li-Ting; Huang, Su-Hua; Huang, Zhi‐Guang; Dang, Yi‐Wu; He, Juan; Zeng, Jiang‐Hui; Wei, Zhu‐Xin; Lu, Wei; Chen, Gang

doi:10.1016/j.ejbt.2022.09.002

Cited by 1 publication

(1 citation statement)

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“…LogFC values for Itgav, Mapk8, Cd34, and Itga4 are reported as 3.33, 3.83, -3.63, and 2.71. The up-regulation of Itgav in nasopharyngeal carcinoma has been investigated by Huang et al 22 Assessments showed that Mapk8 is involved in corneal pain syndrome in severe dry eye disease. 23 An evaluation revealed that FLT3 and mutations of nucleophosmin induce the down-regulation of CD34 in blasts of patients with acute myelogenous leukaemia.…”

Section: Discussionmentioning

confidence: 99%

Network Analysis of Effect of Light-Dark Time Ratio on the Gene Expression Profile of Mouse Skin

et al. 2022

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Introduction: Circadian rhythms refer to daily cyclic events such as activity and rest in biology. A protein-based core related to the mechanism of circadian is identified. In the present study, the gene expression profiles of mouse skin in different conditions of light-dark times were investigated via protein-protein interaction (PPI) analysis to explore the main affected genes. Methods: GSE174155 was derived from Gene Expression Omnibus (GEO) and was analyzed via GEO2R to find the significant differentially expressed genes (DEGs). The gene expression profiles of Cry-null (genotype: cryptochrome-1(-/-): crytochrome-2 (-/-)) mouse skin versus the wild-type samples in the various circadian times (CTs) were assessed. The queried DEGs plus 50 first neighbors were included in a PPI network via the STRING database by Cytoscape software. The networks were analyzed and the central nodes were evaluated. Results: Three groups of mice based on CTs were identified. 15, 15, and 14 central nodes were determined as central nodes for the analyze networks. There was not a common central node for the analyzed networks. Conclusion: It was pointed out that the light/dark time ratio had a gross effect on the gene expression profile of the skin in the mice. Results imply more investigations to suggest a standard protocol related to CT, considering human lifestyle and exploring suitable protective methods for the jobs which are fixed in the abnormal CT sets.

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Section: Discussionmentioning

confidence: 99%