Upregulation of LAGE3 correlates with prognosis and immune infiltrates in colorectal cancer: A bioinformatic analysis

Dong, Xubin; Lv, Shihui; Zhang, Xiaohua; Hao, Rutian

doi:10.1016/j.intimp.2020.106599

Cited by 16 publications

(12 citation statements)

References 41 publications

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“…Previous studies reported that LAGE3 was significantly overexpressed in different types of cancer, compared to their corresponding normal tissues (17). We also found that upregulated LAGE3 expression was associated with various malignant features in ccRCC (18,19,48). In the present study, we demonstrated that LAGE3 was highly up-regulated in BC tissues compared to normal breast tissues in six public datasets, which contained more than 3,500 patients.…”

Section: Discussionsupporting

confidence: 57%

“…Begik et al identified LAGE3 as one of the top-ranked up-regulated RNA modification-related proteins in human cancers (17). In our previous research, we found that LAGE3 was a prognostic biomarker associated with levels of immune infiltration in colorectal cancer (CRC), clear cell renal cell cancer (ccRCC), and malignant pleural mesothelioma microenvironment (18)(19)(20). Goswami MT et al had found that knockdown of LAGE3 significantly reduced cell proliferation in NSCLC cell lines (21).…”

Section: Introductionmentioning

confidence: 83%

“…In our previous research, we found that LAGE3 up-regulation could independently predict poor prognosis in CRC and ccRCC patients (18,19). For BC, the analysis of multiple BC cohorts indicated that high LAGE3 transcript expression was associated with poor prognosis.…”

Section: A B D Cmentioning

confidence: 94%

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Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer

Dong

et al. 2021

Front. Oncol.

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The role of L Antigen Family Member 3 (LAGE3) in breast cancer (BC) has not been sufficiently studied. In this study, we explored the clinical value and biological functions of LAGE3 in BC. Comprehensive analysis of LAGE3 was carried out on The Cancer Genome Atlas, Molecular Taxonomy of Breast Cancer International Consortium and Gene Expression Omnibus datasets. Results showed that LAGE3 expression was higher in BC tissues than in normal breast tissues of public datasets and our local cohort. Moreover, its expression was higher in BC patients with larger tumor size, significant lymph node metastasis, higher tumor grade, and more advanced disease stage. High expression of LAGE3 was correlated with poor prognosis, and LAGE3 could independently predict survival of BC patients. Functional enrichment analysis revealed a correlation between LAGE3 expression and biochemical metabolism and immune-related terms and cancer-related pathways. Analysis of tumor microenvironment indicated that LAGE3 expression was associated with the immune cell infiltration and anti-cancer immunity cycle. LAGE3 expression was higher in triple-negative breast cancer (TNBC) compared to hormone receptor-positive BC, but not HER2-positive subtype. Suppression of LAGE3 expression inhibited the proliferation and induced apoptosis of TNBC cell lines. Besides, the down-regulation of LAGE3 attenuated the migration and invasion but reduced the expression level of epithelial-mesenchymal-transition related proteins in TNBC cell lines. In conclusion, this study demonstrated for the first time that LAGE3 promotes the progression of BC. Therefore, it may be a potential diagnostic and prognostic biomarker, as well as a treatment target for BC.

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Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 83%

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Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer

Dong

et al. 2021

Front. Oncol.

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“…Based on the functional enrichment analysis of the LAGE3 protein and the correlation with CM and immune infiltration, we demonstrated that the expression of LAGE3 had a negative correlation with the immune cell infiltration in the CM. Besides, it has been reported that LAGE3 was negatively correlated with the levels of infiltration for multiple immune cells, especially CD8 + T cells in colorectal cancer and clear cell renal cell carcinoma [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Besides, a previous study demonstrated that a recessive mutation in the LAGE3 gene encodes one of four subunits in Galloway-Mowat syndrome (GAMOS) [15]. Besides, the immune-related prognostic analysis of LAGE3 in colorectal cancer, clear cell renal cell cancer, and malignant pleural mesothelioma has been documented [16][17][18]. It is important to identify a potentially reliable immune signature for melanoma metastasis.…”

Section: Introductionmentioning

confidence: 99%

L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma

Song

Jin

Chen

et al. 2021

BioMed Research International

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L Antigen Family Member 3 (LAGE3) is an important RNA modification-related protein. Whereas few studies have interrogated the LAGE3 protein, there is limited data on its role in tumors. Here, we analyzed and profiled the LAGE3 protein in skin cutaneous melanoma (CM) using TCGA, GTEx, or GEO databases. Our data showed an upregulation of LAGE3 in melanoma cell lines compared to normal skin cell lines. Besides, the Kaplan–Meier curves and Cox proportional hazard model revealed that LAGE3 was an independent survival indicator for CM, especially in metastatic CM. Moreover, LAGE3 was negatively associated with multiple immune cell infiltration levels in CM, especially CD8+ T cells in metastatic CM. Taken together, our study suggests that LAGE3 could be a potential prognostic biomarker and might be a potential target for the development of novel CM treatment strategies.

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LAGE3 correlates with tumorigenic immune infiltrates in the clear cell renal cell carcinoma microenvironment

Dong

Wang

et al. 2020

International Immunopharmacology

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Upregulation of LAGE3 correlates with prognosis and immune infiltrates in colorectal cancer: A bioinformatic analysis

Cited by 16 publications

References 41 publications

Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer

Up-regulation of L Antigen Family Member 3 Associates With Aggressive Progression of Breast Cancer

L Antigen Family Member 3 Serves as a Prognostic Biomarker for the Clinical Outcome and Immune Infiltration in Skin Cutaneous Melanoma

LAGE3 correlates with tumorigenic immune infiltrates in the clear cell renal cell carcinoma microenvironment

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