Upregulation of lncRNA PINK1-AS Predicts the Distant Metastasis of Patients with Small Cell Lung Cancer

Luo, Kun; Xu, Shufeng; Zhao, Jing; Liu, Feifei

doi:10.1007/s12033-022-00512-1

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Notably, the gene signature constructed by our group emphasized the interaction of the gene network rather than the biological impact of an individual gene. High plasma PINK1.AS levels in small cell lung cancer patients predicted distant metastasis 39 . In addition, PINK1.AS promoted gastric cancer progression by sponging miR-200a to negatively regulate the expression of G Protein Subunit Alpha I1 (Gαi1) expression 40 .…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a copper homeostasis-related gene signature for the predicting prognosis of breast cancer patients via integrated bioinformatics analysis

Li,

Wei,

Wang

et al. 2024

Sci Rep

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The prognostic value of copper homeostasis-related genes in breast cancer (BC) remains largely unexplored. We analyzed copper homeostasis-related gene profiles within The Cancer Genome Atlas Program breast cancer cohorts and performed correlation analysis to explore the relationship between copper homeostasis-related mRNAs (chrmRNA) and lncRNAs. Based on these results, we developed a gene signature-based risk assessment model to predict BC patient outcomes using Cox regression analysis and a nomogram, which was further validated in a cohort of 72 BC patients. Using the gene set enrichment analysis, we identified 139 chrmRNAs and 16 core mRNAs via the Protein–Protein Interaction network. Additionally, our copper homeostasis-related lncRNAs (chrlncRNAs) (PINK1.AS, OIP5.AS1, HID.AS1, and MAPT.AS1) were evaluated as gene signatures of the predictive model. Kaplan–Meier survival analysis revealed that patients with a high-risk gene signature had significantly poorer clinical outcomes. Receiver operating characteristic curves showed that the prognostic value of the chrlncRNAs model reached 0.795 after ten years. Principal component analysis demonstrated the capability of the model to distinguish between low- and high-risk BC patients based on the gene signature. Using the pRRophetic package, we screened out 24 anticancer drugs that exhibited a significant relationship with the predictive model. Notably, we observed higher expression levels of the four chrlncRNAs in tumor tissues than in the adjacent normal tissues. The correlation between our model and the clinical characteristics of patients with BC highlights the potential of chrlncRNAs for predicting tumor progression. This novel gene signature not only predicts the prognosis of patients with BC but also suggests that targeting copper homeostasis may be a viable treatment strategy.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of a copper homeostasis-related gene signature for the predicting prognosis of breast cancer patients via integrated bioinformatics analysis

Li,

Wei,

Wang

et al. 2024

Sci Rep

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“…DUBR, MIR99AHG, PINK1-AS, SGMS1-AS1, LINC01128, and SCAMP1-AS1 were investigated in LUAD. 63 – 68 Furthermore, it was reported that ARHGAP5-AS1 is upregulated in chemoresistant gastric cancer cells and that the knockdown of the lncRNA reverses the resistance. 69 AL031123.2 can be used as a prognostic factor in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm

Chi,

Song,

Liu

et al. 2023

DIGITAL HEALTH

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Background Although surgical methods are the most effective treatments for colon adenocarcinoma (COAD), the cure rates remain low, and recurrence rates remain high. Furthermore, platelet adhesion-related genes are gaining attention as potential regulators of tumorigenesis. Therefore, identifying the mechanisms responsible for the regulation of these genes in patients with COAD has become important. The present study aims to investigate the underlying mechanisms of platelet adhesion-related genes in COAD patients. Methods The present study was an experimental study. Initially, the effects of platelet number and related genomic alteration on survival were explored using real-world data and the cBioPortal database, respectively. Then, the differentially expressed platelet adhesion-related genes of COAD were analyzed using the TCGA database, and patients were further classified by employing the non-negative matrix factorization (NMF) analysis method. Afterward, some of the clinical and expression characteristics were analyzed between clusters. Finally, least absolute shrinkage and selection operator regression analysis was used to establish the prognostic nomogram. All data analyses were performed using the R package. Results High platelet counts are associated with worse survival in real-world patients, and alternations to platelet adhesion-related genes have resulted in poorer prognoses, based on online data. Based on platelet adhesion-related genes, patients with COAD were classified into two clusters by NMF-based clustering analysis. Cluster2 had a better overall survival, when compared to Cluster1. The gene copy number and enrichment analysis results revealed that two pathways were differentially enriched. In addition, the differentially expressed genes between these two clusters were enriched for POU6F1 in the transcription factor signaling pathway, and for MATN3 in the ceRNA network. Finally, a prognostic nomogram, which included the ALOX12 and ACTG1 genes, was established based on the platelet adhesion-related genes, with a concordance (C) index of 0.879 (0.848–0.910). Conclusion The mRNA expression-based NMF was used to reveal the potential role of platelet adhesion-related genes in COAD. The series of experiments revealed the feasibility of targeting platelet adhesion-associated gene therapy.

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Mechanistic insights on the role of competing endogenous RNA regulatory networks (ceRNETs) in small cell lung cancer

Kumar

2024

Advances in Cancer Biology - Metastasis

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Upregulation of lncRNA PINK1-AS Predicts the Distant Metastasis of Patients with Small Cell Lung Cancer

Cited by 4 publications

References 18 publications

Identification and validation of a copper homeostasis-related gene signature for the predicting prognosis of breast cancer patients via integrated bioinformatics analysis

Identification and validation of a copper homeostasis-related gene signature for the predicting prognosis of breast cancer patients via integrated bioinformatics analysis

Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm

Mechanistic insights on the role of competing endogenous RNA regulatory networks (ceRNETs) in small cell lung cancer

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