Upregulation of miR-200b Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration by Targeting HMGB3 Protein

Wang, Long-Kun; Xie, Xina; Song, Xuhong; Su, Ting; Chang, Xiaolan; Xu, Man; Liang, Bin; Huang, Dongyang

doi:10.1177/1533033818806475

Cited by 29 publications

(32 citation statements)

References 37 publications

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“…Recent papers have elucidated the tumor-promoting role of HMGB3 in various ranges of cancers. [16][17][18] Thus, we investigated the mechanism of PITPNA-AS1 in regulating HMGB3. It was uncovered that PITPNA-AS1 was located in the cytoplasm of LUSC cells, implying that PITPNA-AS1 potentially regulated HMGB3 at post-transcriptional level.…”

Section: Discussionmentioning

confidence: 99%

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LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

et al. 2020

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Section: Discussionmentioning

confidence: 99%

“…16 MiR-200b restrains hepatocellular carcinoma proliferation as well as migration by reducing HMGB3. 17 The carcinogenic function of HMGB3 in lung cancer has also been proven. 18,19 The precise mechanism in the upstream of HMGB3 in LUSC remains to be investigated.…”

Section: Introductionmentioning

confidence: 99%

LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

et al. 2020

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“…Wang et al 19 Overexpression of miR-205-5p leads to downregulation of HMGB3 and lower abilities in proliferation and metastasis.…”

Section: Hmgb1mentioning

confidence: 99%

Biological functions and theranostic potential of HMGB family members in human cancers

et al. 2020

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The high mobility group box (HMGB) protein family consists of four members: HMGB1, 2, 3, and 4. They share similar amino acid sequences and identical functional regions, especially HMGB1, 2, and 3. The homology in structure may lead to similarity in function. In fact, though their targets may be different, they all possess the fundamental function of binding and distorting target DNAs. However, further research confirmed they are distributed differently in tissues and involved in various distinct physiological and pathological cellular processes, including cell proliferation, division, migration, and differentiation. Recently, the roles of HMGB family members in carcinogenesis has been widely investigated; however, systematic discussion on their functions and clinical values in malignant tumors is limited. In this review, we mainly review and summarize recent advances in knowledge of HMGB family members in terms of structure, distribution, biochemical cascades, and specific mechanisms regarding tumor progression. Importantly, the diagnostic, prognostic, and therapeutic value of these proteins in cancers is discussed. Finally, we envisage the orientation and challenges of this field in further studies.

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“…For instance, miR-BART8-3p has been proven to induce EMT and to promote NPc cell progression by deactivating immune response (16,17). Inversely, the upregulation of miR-200b has been shown to inhibit Hcc cell adhesion and migration by targeting high mobility protein HMGB3 (18). currently, miR-506 is regarded as a novel biomarker for cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA HOXA11‑AS accelerates cell proliferation and epithelial‑mesenchymal transition in hepatocellular carcinoma by modulating the miR‑506‑3p/Slug axis

et al. 2020

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Hepatocellular carcinoma (Hcc) is an aggressively malignant type of cancer with a complex pathogenesis. Multiple studies have identified that lncRNA HOXA11-AS is involved in the development of Hcc. Nevertheless, the pathological mechanisms of HOXA11-AS in the development of Hcc require further investigation. In the present study, the role and underlying mechanisms of HOXA11-AS in HCC were examined. RT-qPCR revealed that HOXA11-AS expression was increased, while that of miR-506-3p was decreased in Hcc tissues and cells compared with that in adjacent non-tumor tissues and normal hepatic cells. dual-luciferase reporter assay and RNA pull-down assay indicated that HOXA11-AS directly interacted with miR-506-3p. miR-506-3p downregulation reversed the inhibitory effects of HOXA11-AS deletion on cell proliferation, invasion and epithelial-mesenchymal transition (EMT), as shown by ccK-8 and Transwell assays, as well as western blot analysis. Bioinformatics analysis and dual-luciferase reporter assay indicated that Slug was a target gene of miR-506-3p. The overexpression of Slug reversed the effects of HOXA11-AS deletion on the viability, invasion and the EMT of Hcc cells. Taken together, the present study demonstrates that HOXA11-AS functions as an oncogene to promote the progression of Hcc via the miR-506-3p/Slug axis, providing a therapeutic target for patients with Hcc.

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Upregulation of miR-200b Inhibits Hepatocellular Carcinoma Cell Proliferation and Migration by Targeting HMGB3 Protein

Cited by 29 publications

References 37 publications

LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

Biological functions and theranostic potential of HMGB family members in human cancers

Long non‑coding RNA HOXA11‑AS accelerates cell proliferation and epithelial‑mesenchymal transition in hepatocellular carcinoma by modulating the miR‑506‑3p/Slug axis

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