Upregulation of miR-371-373 cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma

Ghasemi, Majid; Samaei, Nader Mansour; Mowla, Seyed Javad; Shafiee, Mohammad; Vasei, Mohammad; Ghasemian, Nadia

doi:10.4103/0973-1482.171361

Cited by 19 publications

(8 citation statements)

References 32 publications

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“…Expression of miR-371–37 cluster has been assessed in Iranian ESCC samples and demonstrated the miR-371–373 over expression in tumors compared with normal margins. It was suggested that the miR-371–373 over expression can be involved in tumorigenesis through cell cycle regulators such as CDK2, CDK4, and CDK6 [30]. MiR-451 is another important regulator of cell proliferation, migration, and apoptosis which is related to different factors such as CAB39 [103], RAB14 [96], and MIF [104].…”

Section: Main Textmentioning

confidence: 99%

Genetic and molecular bases of esophageal Cancer among Iranians: an update

2019

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Background Esophageal cancer is one of the leading causes of cancer related deaths among the Iranians. There is still a high ratio of mortality and low 5 years survival which are related to the late onset and diagnosis. Majority of patients refer for the treatment in advanced stages of tumor progression. Main body It is required to define an efficient local panel of diagnostic and prognostic markers for the Iranians. Indeed such efficient specific panel of markers will pave the way to decrease the mortality rate and increase the 5 years survival among the Iranian patients via the early diagnosis and targeted therapy. Conclusion in present review we have reported all of the molecular markers in different signaling pathways and cellular processes which have been assessed among the Iranian esophageal cancer patients until now.

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Section: Main Textmentioning

confidence: 99%

Genetic and molecular bases of esophageal Cancer among Iranians: an update

2019

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“…Among them, the miR-371–373 cluster and the miR-302 cluster are found overexpressed in TGCTs. Members of the miR-371–373 cluster are the prevalent miRNAs in human embryonic stem cells and are involved in self-renewal processes and in maintaining the pluripotency status of ESCs [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

RAS/Mitogen-Activated Protein Kinase Signaling Pathway in Testicular Germ Cell Tumors

Onorato,

Guida,

Colopi

et al. 2024

Life

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Germ cell tumors (GCTs) are relatively rare tumors. However, they are the most diagnosed malignancies occurring in the testis among men aged between 15 and 40 years. Despite high aneuploidy and a paucity of somatic mutations, several genomic and transcriptomic assays have identified a few significantly mutated somatic genes, primarily KIT and K-RAS. The receptor Tyrosine Kinase (RTK) pathway and the downstream related Mitogen-Activated Protein Kinase (MAPK) cascades are crucial signal transduction pathways that preside over various cellular processes, including proliferation, differentiation, apoptosis, and responses to stressors. They are well described in solid malignancies, where many of the involved factors are used as prognostic molecular markers or targets for precision therapy. This narrative review focused, in the first part, on PGCs’ survival/proliferation and differentiation and on the genetic and epigenetic factors involved in the pathogenesis of testicular germ cell tumors (TGCTs) and, in the second part, on the most recent investigations about the KIT-RAS pathway in TGCTs and in other cancers, highlighting the efforts that are being made to identify targetable markers for precision medicine approaches.

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“…According to the literature, human embryonic stem cells (ESCs) contain microRNA-371–373 (miR-371–373) gene clusters in a highly abundant form, indicating that miR-371–373 genes are important in the maintenance of stemness in ESCs [ 13 ]. Through this, the miR-371–373 gene cluster, involved in signaling pathways, such as the Wnt/β-catenin pathway, can promote stem cell self-renewal and oncogenesis in various tissues [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells

Shah

Miao

Chu

et al. 2023

IJMS

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Human INO80 chromatin remodeling complex (INO80 complex) as a transcription cofactor is widely involved in gene transcription regulation and is frequently highly expressed in tumor cells. However, few reports exist on the mutual regulatory mechanism between INO80 complex and non-coding microRNAs. Herein, we showed evidence that the INO80 complex transcriptionally controls microRNA-372 (miR-372) expression through RNA-Seq analysis and a series of biological experiments. Knocking down multiple subunits in the INO80 complex, including the INO80 catalytic subunit, YY1, Ies2, and Arp8, can significantly increase the expression level of miR-372. Interestingly, mimicking miR-372 expression in HCT116 cells, in turn, post-transcriptionally suppressed INO80 and Arp8 expression at both mRNA and protein levels, indicating the existence of a mutual regulatory mechanism between the INO80 complex and miR-372. The target relationship between miR-372 and INO80 complex was verified using luciferase assays in HCT116 colon cancer cells. As expected, miR-372 mimics significantly suppressed the luciferase activity of pMIR-luc/INO80 and pMIR-luc/Arp8 3′-UTR in cells. In contrast, the miR-372 target sites in the 3′-UTRs linked to the luciferase reporter were mutagenized, and both mutant sites lost their response to miR-372. Furthermore, the mutual modulation between the INO80 complex and miR-372 was involved in cell proliferation and the p53/p21 signaling pathway, suggesting the synergistic anti-tumor role of the INO80 complex and miR372. Our results will provide a solid theoretical basis for exploring miR-372 as a biological marker of tumorigenesis.

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Upregulation of miR-371-373 cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma

Abstract: Our findings support the hypothesis that these miRNAs might play a role in tumorigenesis in esophageal cancer.

Cited by 19 publications

References 32 publications

Genetic and molecular bases of esophageal Cancer among Iranians: an update

Genetic and molecular bases of esophageal Cancer among Iranians: an update

RAS/Mitogen-Activated Protein Kinase Signaling Pathway in Testicular Germ Cell Tumors

Feedback Modulation between Human INO80 Chromatin Remodeling Complex and miR-372 in HCT116 Cells

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