Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin

Chen, Yuewen; Cao, Lingzhi; Ye, Jianwei; Zhu, Dahai

doi:10.1016/j.bbrc.2009.07.129

Cited by 55 publications

(44 citation statements)

References 24 publications

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“…Mice injected with an equal volume of sodium citrate buffer were maintained as control groups. Nonfasting body weight and random blood glucose levels were determined on the day of injection and subsequently on Day 1,2,4,5,7,8,9,11,12,13,14,15,16, and 18. Mice were fasted for 9 -10 h and body weight and fasting blood glucose was measured on Day 3, 6, 10, and 17.…”

Section: Methodsmentioning

confidence: 99%

“…Our laboratory has shown recently that Mstn can induce ROS and in turn Anti-oxidant enzymes in skeletal muscle through TNF-␣ and NADPH oxidase (Nox) in a feed-forward manner (6). Previously it was reported that Mstn expression and level was up-regulated in skeletal muscle of rodents with type 1 diabetes induced by Streptozotocin (STZ) (7,8,9). Furthermore, Mstn expression was attenuated by insulin administration in STZ-induced type 1 diabetic mice (7).…”

mentioning

confidence: 99%

“…Previously it was reported that Mstn expression and level was up-regulated in skeletal muscle of rodents with type 1 diabetes induced by Streptozotocin (STZ) (7,8,9). Furthermore, Mstn expression was attenuated by insulin administration in STZ-induced type 1 diabetic mice (7). However, the signaling mechanisms by which high glucose levels induce Mstn expression are still unknown.…”

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confidence: 99%

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Myostatin Induces DNA Damage in Skeletal Muscle of Streptozotocin-induced Type 1 Diabetic Mice

Sriram

Subramanian

Juvvuna

et al. 2014

Journal of Biological Chemistry

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Myostatin Induces DNA Damage in Skeletal Muscle of Streptozotocin-induced Type 1 Diabetic Mice

Sriram

Subramanian

Juvvuna

et al. 2014

Journal of Biological Chemistry

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“…AAC are more frequent in diabetic patients; however, the investigated association remained significant after adjustment for diabetes. Moreover, data on myostatin secretion in experimental diabetes are discordant, whereas a recent clinical study showed that diabetic patients had an increased expression of the myostatin gene, but plasma myostatin concentrations similar to nondiabetic controls (41,42,43).…”

Section: Discussionmentioning

confidence: 99%

Serum myostatin levels are negatively associated with abdominal aortic calcification in older men: the STRAMBO study

Szulc¹,

Hofbauer²,

Rauner³

et al. 2012

European Journal of Endocrinology

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Objective: To assess the association between abdominal aortic calcification (AAC) and serum levels of myostatin, a negative regulator of skeletal muscle mass, which has been implicated in the development of atherosclerotic lesions in mice. Design and patients: We assessed AAC semiquantitatively from the lateral spine scans obtained using dual energy X-ray absorptiometry in 1071 men aged 20-87 years. Serum myostatin levels were measured by an immunoassay that detects all myostatin forms. Results: Total myostatin serum levels did not differ between men with or without self-reported ischemic heart disease, hypertension, or diabetes mellitus. Total serum myostatin levels were higher in men with higher serum calcium levels and lower in men with higher serum concentrations of highly sensitive C-reactive protein. Men with AAC had lower myostatin levels compared with men without AAC. Prevalence of AAC (AAC score O0) was lower in the highest myostatin quartile compared with the three lower quartiles (P!0.05). After adjustment for confounders, odds of AAC (AAC score O0) were lower (ORZ0.62; 95% confidence interval (95% CI), 0.45-0.85; P!0.005) for the fourth myostatin quartile vs the three lower quartiles combined. In the sub-analysis of 745 men aged R60 years, the results were similar: AAC prevalence was lower in the highest myostatin quartile compared with the three lower quartiles combined (ORZ0.54; 95% CI, 0.38-0.78; P!0.001). Conclusions: In older men, total myostatin serum levels are inversely correlated with AAC. Further studies are needed to investigate mechanisms underlying this association and to assess utility of myostatin as a cardiovascular marker.

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“…Introduction of MSTN null mutation into different obese strains or deletion of MSTN in mice results in skeletal muscle hypertrophy and, in contrast, reduction in fat accumulation and prevention of insulin resistance (2)(3)(4)(5)7,8,(10)(11)(12)(13). In addition, MSTN gene expression in muscle was upregulated and attenuated by insulin in streptozotocin-induced type 1 diabetic mice (14).…”

Section: Introductionmentioning

confidence: 99%

Exercise alters myostatin protein expression in sedentary and exercised streptozotocin-diabetic rats

Bassi

Bueno

Nonaka

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The aim of this study was to analyze the effect of exercise on the pattern of muscle myostatin (MSTN) protein expression in two important metabolic disorders, i.e., obesity and diabetes mellitus. Materials and methods: MSTN, is a negative regulator of skeletal muscle mass. We evaluated the effect of exercise on MSTN protein expression in diabetes mellitus and high fat diet-induced obesity. MSTN protein expression in gastrocnemius muscle was analyzed by Western Blot. P < 0.05 was assumed. Exercise induced a significant decrease in glycemia in both diabetic and obese animals. Results: The expression of precursor and processed protein forms of MSTN and the weight of gastrocnemius muscle did not vary in sedentary or exercised obese animals. Diabetes reduced gastrocnemius muscle weight in sedentary animals. However, gastrocnemius muscle weight increased in diabetic exercised animals. Both the precursor and processed forms of muscle MSTN protein were significantly higher in sedentary diabetic rats than in control rats. The precursor form was significantly lower in diabetic exercised animals than in diabetic sedentary animals. However, the processed form did not change. Conclusion: These results demonstrate that exercise can modulate the muscle expression of MSTN protein in diabetic rats and suggest that MSTN may be involved in energy homeostasis. Arch Endocrinol Metab. 2015;59(2):148-53

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Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin

Cited by 55 publications

References 24 publications

Myostatin Induces DNA Damage in Skeletal Muscle of Streptozotocin-induced Type 1 Diabetic Mice

Myostatin Induces DNA Damage in Skeletal Muscle of Streptozotocin-induced Type 1 Diabetic Mice

Serum myostatin levels are negatively associated with abdominal aortic calcification in older men: the STRAMBO study

Exercise alters myostatin protein expression in sedentary and exercised streptozotocin-diabetic rats

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