Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer

Zhang, Wei; He, Jian; Du, Yan; Xian, Gao; Liu, Yan; Liu, Qizhi; Chang, Wenjun; Cao, Guangwen; Fu, Chuangang

doi:10.3748/wjg.v21.i29.8836

Cited by 27 publications

(34 citation statements)

References 29 publications

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“…For instance, Zhu et al, found that Twist1 could enhance proliferation and chemoresistance of CRC cells which might be a potential prognostic marker and a molecular therapeutic target for the cancer [21]. Zhang et al indicated that up-regulation of nemolike kinase (NLK) was positively correlated with recurrence and distant metastasis of CRC patients, predicting poor prognosis for patients with the disease [22]. The clinical signi cance of MTA2 expression for prognosis of CRC was investigated by Ding et al They found the expression pro le of MTA2 exhibited high in CRC tissues specimens, and signi cantly correlated with overall survival of the patients, suggesting its possible as a prognostic biomarker for CRC [23].…”

Section: Discussionmentioning

confidence: 99%

EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses

Yan¹,

Du²,

Xia³

et al. 2020

Preprint

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Background Eyes absent 4 (EYA4) is involved in various biological processes. The aim of this study was to investigate the expression of EYA4 and its prognostic value in colorectal cancer (CRC). Methods The mRNA level of EYA4 in diseased tissues and adjacent normal tissues of CRC patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The association between EYA4 expression and clinicopathological characteristics was analyzed by χ2 test. Kaplan-Meier analysis with log rank test was performed to evaluate the effects of EYA4 expression on overall survival of CRC patients. Cox regression model was applied for prognosis analysis in CRC. Results The mRNA level of EYA4 was significantly decreased in CRC tissues compared with that in the adjacent normal tissue (P < 0.01). And its expression was affected by DUKE stage (P = 0.034), differentiation (P = 0.027) and vascular invasion (P = 0.037). Survival curve showed that patients with low expression of EYA4 had a significantly shorter overall survival than those with high expression (log rank test, P = 0.008). Low expression of EYA4 (HR = 1.989, 95%CI = 1.090-3.62902, P = 0.025) was an independent biomarker for poor prognosis in CRC patients. Conclusion EYA4 expression is decreased in CRC patients and negatively correlated with aggressive tumor progression. EYA4 may be a potential prognostic biomarker for CRC.

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Section: Discussionmentioning

confidence: 99%

EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses

Yan¹,

Du²,

Xia³

et al. 2020

Preprint

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show abstract

“…They aid in metabolism and nutrient availability by fermenting complex carbohydrates into short-chain fatty acids (SCFA), which can be used as an energy source by mucosa. Bacteria can also produce vitamins, such as vitamin K and components of certain vitamin B species ( 17 ), and play a role in the metabolism of medications. Gut microbiota also aid in the protection against pathogens by competitive exclusion ( 16 , 17 ).…”

Section: Key Players Of the Human Gut Microbiotamentioning

confidence: 99%

“…Bacteria can also produce vitamins, such as vitamin K and components of certain vitamin B species ( 17 ), and play a role in the metabolism of medications. Gut microbiota also aid in the protection against pathogens by competitive exclusion ( 16 , 17 ). The tremendous contribution of bacteria to host physiology is best seen in germfree (GF) mice, which have impaired development of the epithelium, musculature, and vasculature of the intestines as well as systemic defects, such as in immune functions and brain development.…”

Section: Key Players Of the Human Gut Microbiotamentioning

confidence: 99%

“…ILC can be divided into three groups based on molecular markers: type 1 which expresses T box transcription factor (TBX21 or T-bet) in T cells, type 2 which expresses GATA binding protein and type 3 which expresses retinoid-related orphan receptor (ROR)γt. Type 3 ILC produce IL-17 and IL-22, and IL-22 production can be induced by bacterial metabolites acting on the aryl hydrocarbon receptor (AHR) ( 17 ). The pro-inflammatory reactions caused by gut microbiota may contribute to MS pathogenesis via the activation of autoreactive T-cells ( 36 ).…”

Section: The Influence Of Gut Microbiota On Extraintestinal Tissuesmentioning

confidence: 99%

“…Tryptophan-derived AHR ligands limit astrocyte-mediated inflammation in the CNS ( 84 ). Aryl hydrocarbon receptor ligands may also act on type 3 ILC ( 17 ).…”

Section: Diet-based Interventions In Eae Modelsmentioning

confidence: 99%

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Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota

2017

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Multiple sclerosis (MS) is an autoimmune neurological disease characterized by chronic inflammation of the central nervous system (CNS), leading to demyelination, axonal damage, and symptoms such as fatigue and disability. Although the cause of MS is not known, the infiltration of peripherally activated immune cells into the CNS has a key pathogenic role. Accumulating evidence supports an important role of diet and gut microbiota in immune-mediated diseases. Preclinical as well as clinical studies suggest a role for gut microbiota and dietary components in MS. Here, we review these recent studies on gut microbiota and dietary interventions in MS and its animal model experimental autoimmune encephalomyelitis. We also propose directions for future research.

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In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship

et al. 2021

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The human gut microbiota plays an important role in the maintenance of human health. Factors able to modify its composition might predispose the host to the development of pathologies. Among the various xenobiotics introduced through the diet, Alternaria mycotoxins are speculated to represent a threat for human health. However, limited data are currently available about the bidirectional relation between gut microbiota and Alternaria mycotoxins. In the present work, we investigated the in vitro effects of different concentrations of a complex extract of Alternaria mycotoxins (CE; containing eleven mycotoxins; e.g. 0.153 µM alternariol and 2.3 µM altersetin, at the maximum CE concentration tested) on human gut bacterial strains, as well as the ability of the latter to metabolize or adsorb these compounds. Results from the minimum inhibitory concentration assay showed the scarce ability of CE to inhibit the growth of the tested strains. However, the growth kinetics of most of the strains were negatively affected by exposure to the various CE concentrations, mainly at the highest dose (50 µg/mL). The CE was also found to antagonize the formation of biofilms, already at concentrations of 0.5 µg/mL. LC–MS/MS data analysis of the mycotoxin concentrations found in bacterial pellets and supernatants after 24 h incubation showed the ability of bacterial strains to adsorb some Alternaria mycotoxins, especially the key toxins alternariol, alternariol monomethyl ether, and altersetin. The tendency of these mycotoxins to accumulate within bacterial pellets, especially in those of Gram-negative strains, was found to be directly related to their lipophilicity.

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Upregulation of nemo-like kinase is an independent prognostic factor in colorectal cancer

Abstract: NLK overexpression is an independent prognostic factor in colorectal cancer and knockdown of NLK expression inhibits colorectal cancer progression and metastasis.

Cited by 27 publications

References 29 publications

EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses

EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses

Modulation of Multiple Sclerosis and Its Animal Model Experimental Autoimmune Encephalomyelitis by Food and Gut Microbiota

In vitro interactions of Alternaria mycotoxins, an emerging class of food contaminants, with the gut microbiota: a bidirectional relationship

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