Upregulation of NK cell activity, cytokine expression, and NF-κB pathway by ginsenoside concentrates from Panax ginseng berries in healthy mice and macrophage cell lines

Jang, Jiwon; He, Ziliang; Huang, Lei; Hwang, Ji Yeon; Kim, Mi-Yeon; Cho, Jae Youl

doi:10.1016/j.jep.2024.118681

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2024

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Cited by 2 publications

References 83 publications

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Shenjiaolingcao Decoction Ameliorate Cyclophosphamide-Induced Splenic Injury and Immunosuppression Via the Inhibition of Mapk/Mek/Erk Signaling Pathway Activity and Modulation of Amino Acid Metabolism

He,

Liu,

et al. 2024

Preprint

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Shenjiaolingcao Decoction Ameliorate Cyclophosphamide-Induced Splenic Injury and Immunosuppression Via the Inhibition of Mapk/Mek/Erk Signaling Pathway Activity and Modulation of Amino Acid Metabolism

He,

Liu,

et al. 2024

Preprint

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A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries

Wang,

Han,

et al. 2024

Molecules

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This study was conducted to investigate the differences in chemical composition between red (RGBs) and yellow ginseng berries (YGBs) and their whitening and anti-aging skincare effects. The differences in the chemical composition between RGB and YGB were analyzed by ultra-high-performance liquid chromatography tandem quadrupole electrostatic field orbit trap mass spectrometry (UHPLC-Q-Exactive-MS/MS) combined with multivariate statistics. An aging model was established using UVB radiation induction, and the whitening and anti-aging effects of the two ginseng berries were verified in vitro and in vivo using cell biology (HaCaT and B16-F10 cells) and zebrafish model organisms. A total of 31 differential compounds, including saponins, flavonoids, phenolic acids, and other chemical constituents, were identified between the two groups. Superoxide dismutase (SOD) activity was more significantly increased (p < 0.05) and malondialdehyde (MDA) content was more significantly decreased (p < 0.01) in RGB more than YGB induced by UVB ultraviolet radiation. In terms of whitening effects, YGB was more effective in inhibiting the melanin content of B16-F10 cells (p < 0.01). The results of zebrafish experiments were consistent with those of in vitro experiments and cell biology experiments. The DCFH fluorescence staining results revealed that both ginseng berries were able to significantly reduce the level of reactive oxygen species (ROS) in zebrafish (p < 0.01). Comparison of chemical composition and skin care activities based on RGB and YGB can provide a theoretical basis for the deep development and utilization of ginseng berry resources.

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Upregulation of NK cell activity, cytokine expression, and NF-κB pathway by ginsenoside concentrates from Panax ginseng berries in healthy mice and macrophage cell lines

Cited by 2 publications

References 83 publications

Shenjiaolingcao Decoction Ameliorate Cyclophosphamide-Induced Splenic Injury and Immunosuppression Via the Inhibition of Mapk/Mek/Erk Signaling Pathway Activity and Modulation of Amino Acid Metabolism

Shenjiaolingcao Decoction Ameliorate Cyclophosphamide-Induced Splenic Injury and Immunosuppression Via the Inhibition of Mapk/Mek/Erk Signaling Pathway Activity and Modulation of Amino Acid Metabolism

A Comparative Study of the Chemical Composition and Skincare Activities of Red and Yellow Ginseng Berries

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