Upregulation of p67<sup>phox</sup> in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3

Zhao, Liang; Zhang, Rui; Zhang, Shuya; Zhang, Hualu; Yang, Qing; Xu, Zhelong

doi:10.1080/10715762.2022.2052057

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Zhao et al also reported that, as the expression regulation of ZIP2 in I/R injury, the NADPH oxidase isoform (NOX2) cytosolic factor p67 phox and p67 phox -derived ROS production was upregulated in I/R injury and operated ZIP2 expression via STAT3 phosphorylation. In contrast, the I/R-induced loss of zinc content in the heart upregulated p67 phox expression [ 53 ].…”

Section: Zinc Transporters Regulating Cardiovascular Functionsmentioning

confidence: 99%

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Hara

Yoshigai

Ohashi

et al. 2023

IJMS

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Zinc is an essential trace element that plays an important physiological role in numerous cellular processes. Zinc deficiency can result in diverse symptoms, such as impairment of the immune response, skin disorders, and impairments in cardiovascular functions. Recent reports have demonstrated that zinc acts as a signaling molecule, and its signaling pathways, referred to as zinc signals, are related to the molecular mechanisms of cardiovascular functions. Therefore, comprehensive understanding of the significance of zinc-mediated signaling pathways is vital as a function of zinc as a nutritional component and of its molecular mechanisms and targets. Several basic and clinical studies have reported the relationship between zinc level and the onset and pathology of cardiovascular diseases, which has attracted much attention in recent years. In this review, we summarize the recent findings regarding the effects of zinc on cardiovascular function. We also discuss the importance of maintaining zinc homeostasis in the cardiovascular system and its therapeutic potential as a novel drug target.

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Section: Zinc Transporters Regulating Cardiovascular Functionsmentioning

confidence: 99%

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Hara

Yoshigai

Ohashi

et al. 2023

IJMS

View full text Add to dashboard Cite

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Toxic Effects of Intracellular Free Zinc Ion in Cardiomyocytes via Zinc-Transporters: Structural and Functional Changes in Mitochondria

Turan,

Billur,

Tuncay

2024

Advances in Biochemistry in Health and Disease

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Upregulation of p67^phox in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3

Cited by 2 publications

References 28 publications

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Toxic Effects of Intracellular Free Zinc Ion in Cardiomyocytes via Zinc-Transporters: Structural and Functional Changes in Mitochondria

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Upregulation of p67phox in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3

Cited by 2 publications

References 28 publications

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Zinc in Cardiovascular Functions and Diseases: Epidemiology and Molecular Mechanisms for Therapeutic Development

Toxic Effects of Intracellular Free Zinc Ion in Cardiomyocytes via Zinc-Transporters: Structural and Functional Changes in Mitochondria

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Upregulation of p67^phox in response to ischemia/reperfusion is cardioprotective by increasing ZIP2 expression via STAT3