Upregulation of <scp>HMGB1</scp> promotes vascular dysfunction in the soft palate of patients with obstructive sleep apnea via the <scp>TLR4</scp>/<scp>NF‐κB</scp>/<scp>VEGF</scp> pathway

Su, Tianning; Liu, Cong; Yue, Lei; Chen, Yuqin; Qian, Xiaoqiong; Shi, Song

doi:10.1002/2211-5463.13533

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Craniofacial abnormalities, such as excessive or elongated soft palate tissue, are a common contributing factor to upper airway stenosis in OSA 49 . Su et al 50 discovered a noteworthy increase in blood vessels in the lamina propria of the soft palate tissue of OSA patients. The study also revealed significantly higher levels of TLR4, p‐NF‐κB p65, vascular endothelial‐derived growth factor, and matrix metalloproteinase‐9 in the soft palate of OSA patients compared to controls.…”

Section: Molecular Mechanisms Between Gut Microbiome and Osamentioning

confidence: 99%

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

Zhang,

et al. 2024

FASEB BioAdvances

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Obstructive sleep apnea (OSA) is a multifactorial sleep disorder with a high prevalence in the general population. OSA is associated with an increased risk of developing cardiovascular diseases (CVDs), particularly hypertension, and is linked to worse outcomes. Although the correlation between OSA and CVDs is firmly established, the mechanisms are poorly understood. Continuous positive airway pressure is primary treatment for OSA reducing cardiovascular risk effectively, while is limited by inadequate compliance. Moreover, alternative treatments for cardiovascular complications in OSA are currently not available. Recently, there has been considerable attention on the significant correlation between gut microbiome and pathophysiological changes in OSA. Furthermore, gut microbiome has a significant impact on the cardiovascular complications that arise from OSA. Nevertheless, a detailed understanding of this association is lacking. This review examines recent advancements to clarify the link between the gut microbiome, OSA, and OSA‐related CVDs, with a specific focus on hypertension, and also explores potential health advantages of adjuvant therapy that targets the gut microbiome in OSA.

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Section: Molecular Mechanisms Between Gut Microbiome and Osamentioning

confidence: 99%

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

Zhang,

et al. 2024

FASEB BioAdvances

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The common link between sleep apnea syndrome and osteoarthritis: a literature review

Weng,

Luo,

Luo

et al. 2024

Front. Med.

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Patients with Osteoarthritis (OA) often also suffer from Sleep Apnea Syndrome (SAS), and many scholars have started to notice this link, although the relationship between the two is still unclear. In this review, we aim to summarize the current literature on these two diseases, integrate evidence of the OA and OSA connection, explore and discuss their potential common mechanisms, and thus identify effective treatment methods for patients with both OA and SAS. Some shared characteristics of the two conditions have been identified, notably aging and obesity as mutual risk factors. Both diseases are associated with various biological processes or molecular pathways, including mitochondrial dysfunction, reactive oxygen species production, the NF-kB pathway, HIF, IL-6, and IL-8. SAS serves as a risk factor for OA, and conversely, OA may influence the progression of SAS. The effects of OA on SAS are underreported in the literature and require more investigation. To effectively manage these patients, timely intervention for SAS is necessary while treating OA, with weight reduction being a primary requirement, alongside combined treatments such as Continuous positive airway pressure (CPAP) and medications. Additionally, numerous studies in drug development are now aimed at inhibiting or clearing certain molecular pathways, including ROS, NF-KB, IL-6, and IL-8. Improving mitochondrial function might represent a viable new strategy, with further research into mitochondrial updates or transplants being essential.

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Upregulation of HMGB1 promotes vascular dysfunction in the soft palate of patients with obstructive sleep apnea via the TLR4/NF‐κB/VEGF pathway

Cited by 2 publications

References 37 publications

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases

The common link between sleep apnea syndrome and osteoarthritis: a literature review

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