Upregulation of sodium iodide symporter (NIS) protein expression by an innate immunity component: Promising potential for targeting radiosensitive retinoblastoma

Samuel, Jaisy; Singh, Narinderbir; Kanwar, Jagat R.; Krishnakumar, S.; Kanwar, Rupinder K.

doi:10.1016/j.exer.2015.07.011

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Receptors of Lf are highly expressed in tumor cells because of the enhanced iron demand of rapidly dividing metabolically active tumor cells, 28 including Rb Y79 cells. 29 Drug-loaded Lf-Nps were prepared by oil–solution method, 24 in contrast to other protein nanoparticles, 30 and therefore it is a cost-effective, simple, and fast procedure without chemical modification of native Lf protein. The nanoparticles were uniformly distributed, spherical in shape, and smaller than previously reported Lf-CPT (68–81 nm), 24 which could possibly be due to the preparation of Lf-Nps with clinical-grade CPT.…”

Section: Discussionmentioning

confidence: 99%

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

Narayana

Jana

Tomar

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

Narayana

Jana

Tomar

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…Because of the increased iron need for quickly dividing metabolically active tumor cells, such as Rb Y79 cells, LF receptors are extensively expressed in tumor cells. [ 61 62 ] Oil–solution technique was used to make drug-loaded LF-NPS. It is a low-cost, simple, and quick process that does not require chemical alteration of the natural LF protein.…”

Section: Methodsmentioning

confidence: 99%

Lactoferrin and its nano-formulations in rare eye diseases

Singh

Sharma

Jain

et al. 2022

Indian Journal of Ophthalmology

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Lactoferrin (LF) is an iron-binding glycoprotein released from mucous secreting cells and neutrophils. LF can be used in a broad range of eye diseases related to the retina, cornea, and optic nerve. The retina is particularly affected by oxidative stress inside the photoreceptor being constantly exposed to light which induces accumulation of reactive oxygen species (ROS) in the retinal pigmented epithelium (RPE) causing damage to photoreceptor recycling. Retinitis pigmentosa (RP) and macular degeneration are inherited retinopathies that consist of different disease-causing genes, that cause mutations with highly varied clinical consequences. Age-related macular degeneration is a chronic disease of the retina and one of the major causes of sight loss. This review provides an application of lactoferrin and LF-based nano-formulations or nanoparticles in the field of retinal diseases or corneal diseases such as retinitis pigmentosa, retinoblastoma, age-related macular degeneration (AMD), keratoconus and uveitis. Several studies have found that lactoferrin’s antibacterial activity is not limited to its iron sequestration, but also its ability as a nanoparticle that acts as a carrier to deliver drugs by crossing the blood–retina barrier (BRB) and its involvement in cell cycle control, which is not possible by many transferrin proteins.

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Nanomedicine-Based Delivery to the Posterior Segment of the Eye: Brighter Tomorrow

Jalil

Kanwar

Pathak

et al. 2018

Drug Delivery for the Retina and Posterior Segment Disease

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Upregulation of sodium iodide symporter (NIS) protein expression by an innate immunity component: Promising potential for targeting radiosensitive retinoblastoma

Cited by 3 publications

References 27 publications

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

Carboplatin- and Etoposide-Loaded Lactoferrin Protein Nanoparticles for Targeting Cancer Stem Cells in Retinoblastoma In Vitro

Lactoferrin and its nano-formulations in rare eye diseases

Nanomedicine-Based Delivery to the Posterior Segment of the Eye: Brighter Tomorrow

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