Upregulation of the Long Non-coding RNA LINC01480 Is Associated With Immune Infiltration in Coronary Artery Disease Based on an Immune-Related lncRNA-mRNA Co-expression Network

Xiong, Ting; Xiao, Botao; Qin, Xianyu; Liu, Yunfeng; Li, Quhuan

doi:10.3389/fcvm.2022.724262

Cited by 5 publications

(5 citation statements)

References 54 publications

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“…On the other hand, 508 RCC samples from TCGA were filtered out by a clinical follow-up time of more than 30 days, and the sample labeled ‘01A’ in the dataset was used for the univariate COX analysis. (Liu et al 2022; Xiong et al 2022)…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, 508 RCC samples from TCGA were filtered out by a clinical follow-up time of more than 30 days, and the sample labeled '01A' in the dataset was used for the univariate COX analysis. (Liu et al 2022;Xiong et al 2022) Genes with p <0.001 in univariate COX analysis were retained and further subjected to LASSO-penalized COX analysis with lambda 100. Subsequently, five genes were retained and subjected to a multivariate COX analysis.…”

Section: Establishment Of a Risk Assessment Modelmentioning

confidence: 99%

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A single-cell transcriptome analysis and prognostic model construction of stromal cells for renal cell carcinoma

Liao,

Wang,

Liu

et al. 2023

Preprint

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Renal cell carcinoma (RCC) is among the top three cancers of the urinary system and its incidence keeps increasing worldwide in recent decades. However, methods for accurate prognosis evaluation and effective treatment are still lacking nowadays. Here, to explore the molecular expression features of RCC and establish a new RCC clinical prognosis evaluation model, a cell landscape of 187,263 renal cells obtained from eight patients with RCC was analyzed in this study. And by extracting and focusing on the main stromal cells from RCC tissues, innovative molecular characteristics and pathways of tumors were identified, like the well-known hypoxia pathway. By analyzing cell-cell communication, fibroblasts were found to promote tumor development by repressing natural killer cells. Based on Cox and least absolute shrinkage and selection operator regression analysis, four risk factors were screened and used to construct a reliable RCC clinical risk estimation model. In conclusion, our work provides new insights into the tumor microenvironment of RCC, as well as potential therapeutic targets and a clinical risk model for RCC invasiveness. Hopefully, these findings will be useful for cancer research and clinical treatment in future.

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Section: Methodsmentioning

confidence: 99%

Section: Establishment Of a Risk Assessment Modelmentioning

confidence: 99%

A single-cell transcriptome analysis and prognostic model construction of stromal cells for renal cell carcinoma

Liao,

Wang,

Liu

et al. 2023

Preprint

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“…13,14 Another study has confirmed that exosomal lncRNA acts as a potential diagnostic and prognostic biomarker for GC. 12 LINC01480, a kind of lncRNA, is closely related to immune infiltration in coronary artery disease, 15 while its roles in GC development remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

“…Accumulating pieces of evidence have demonstrated that lncRNAs participate in the occurrence and development of GC by regulating cell proliferation, invasion, migration, and metastasis. , Another study has confirmed that exosomal lncRNA acts as a potential diagnostic and prognostic biomarker for GC . LINC01480, a kind of lncRNA, is closely related to immune infiltration in coronary artery disease, while its roles in GC development remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Tumor-Derived Exosomal LINC01480 Upregulates VCAM1 Expression by Acting as a Competitive Endogenous RNA of miR-204-5p to Promote Gastric Cancer Progression

Zhang,

Guo,

Mao

et al. 2023

ACS Biomater. Sci. Eng.

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Exosomes are a type of cell-derived vesicles that range in size from 30 to 100 nm. They are widely present in various organisms and participate in diverse biological processes, playing crucial roles in tumorigenesis and progression. This study aimed to investigate whether LINC01480 in tumor-derived exosomes is involved in the molecular mechanism of gastric cancer by competitively upregulating the VCAM1 expression through binding miR-204-5p. The study analyzed transcriptome data related to gastric cancer from the cancer genome atlas database and constructed a risk-scoring model for epithelial−mesenchymal transition (EMT)-related lncRNAs to identify eight EMT-related lncRNAs associated with prognosis. EMT-related mRNAs positively correlated with LINC01480 were screened in the ExoRBase database. In vitro cell experiments showed that exosomal LINC01480 can promote the proliferation, migration, invasion, and EMT of gastric cancer cells by upregulating VCAM1 expression through competitive binding with miR-204-5p. In vivo experiments on nude mice showed that exosomal LINC01480 promotes the development of gastric cancer. These results suggest that exosomal LINC01480 could be a potential therapeutic target for gastric cancer.

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“…Kushnareva et al found that the expression of PD-L1 and the number of CD3+ cells in endothelial cells increased in the myocardium of patients with ischemic heart failure (11). Besides, several bioinformatic comprehensive analyses have also confirmed the difference in immune infiltrates between patients with coronary artery disease and healthy controls (12,13). However, the mechanisms underlying immune infiltration in ICM remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Identification and validation of ferroptosis-related genes and immune infiltration in ischemic cardiomyopathy

Huang

Mei

Duan

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCardiomyocyte death is an important pathophysiological basis for ischemic cardiomyopathy (ICM). Many studies have suggested that ferroptosis is a key link in the development of ICM. We performed bioinformatics analysis and experiment validation to explore the potential ferroptosis-related genes and immune infiltration of ICM.MethodsWe downloaded the datasets of ICM from the Gene Expression Omnibus database and analyzed the ferroptosis-related differentially expressed genes (DEGs). Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and protein–protein interaction network were performed to analyze ferroptosis-related DEGs. Gene Set Enrichment Analysis was used to evaluate the gene enrichment signaling pathway of ferroptosis-related genes in ICM. Then, we explored the immune landscape of patients with ICM. Finally, the RNA expression of the top five ferroptosis-related DEGs was validated in blood samples from patients with ICM and healthy controls using qRT-PCR.ResultsOverall, 42 ferroptosis-related DEGs (17 upregulated and 25 downregulated genes) were identified. Functional enrichment analysis indicated several enriched terms related to ferroptosis and the immune pathway. Immunological analysis suggested that the immune microenvironment in patients with ICM is altered. The immune checkpoint-related genes (PDCD1LG2, LAG3, and TIGIT) were overexpressed in ICM. The qRT-PCR results showed that the expression levels of IL6, JUN, STAT3, and ATM in patients with ICM and healthy controls were consistent with the bioinformatics analysis results from the mRNA microarray.ConclusionOur study showed significant differences in ferroptosis-related genes and functional pathway between ICM patients and healthy controls. We also provided insight into the landscape of immune cells and the expression of immune checkpoints in patients with ICM. This study provides a new road for future investigation of the pathogenesis and treatment of ICM.

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Upregulation of the Long Non-coding RNA LINC01480 Is Associated With Immune Infiltration in Coronary Artery Disease Based on an Immune-Related lncRNA-mRNA Co-expression Network

Cited by 5 publications

References 54 publications

A single-cell transcriptome analysis and prognostic model construction of stromal cells for renal cell carcinoma

A single-cell transcriptome analysis and prognostic model construction of stromal cells for renal cell carcinoma

Tumor-Derived Exosomal LINC01480 Upregulates VCAM1 Expression by Acting as a Competitive Endogenous RNA of miR-204-5p to Promote Gastric Cancer Progression

Identification and validation of ferroptosis-related genes and immune infiltration in ischemic cardiomyopathy

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