Upregulation of the Tim-3/Gal-9 pathway and correlation with the development of preeclampsia

Hao, Haiyan; He, Mengzhou; Li, Jing; Zhou, Yuan; Dang, Jing; Li, Fanfan; Yang, Meitao; Deng, Dan

doi:10.1016/j.ejogrb.2015.08.022

Cited by 30 publications

(17 citation statements)

References 37 publications

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“…There are few inconsistent data about the possible role of the TIM-3/Gal-9 pathway in the pathogenesis of preeclampsia. On the one hand, in preeclampsia, both TIM-3 and Gal-9 were found to be upregulated in decidual tissue, and TIM-3 expression of peripheral blood monocytes was shown to increase (4). On the other hand, a decreased ratio of TIM+3+ Th, NK, and Vdelta2+ T cells could be confirmed in the peripheral blood of preeclamptic patients (48, 77).…”

Section: Tim-3mentioning

confidence: 99%

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Immune Checkpoint Molecules in Reproductive Immunology

et al. 2019

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Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity, transplantation, and tumor immune evasion. Maternal-fetal immunotolerance represents a real immunological challenge for the immune system of the mother: beside acceptance of the semiallogeneic fetus, the maternal immune system has to be prepared for immune defense mostly against infections. In this particular situation, the role of immune checkpoint molecules could be of special interest. In this review, we describe current knowledge on the role of immune checkpoint molecules in reproductive immunology.

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Section: Tim-3mentioning

confidence: 99%

“…In order to keep this side effect of the immune response limited and localized, efficient immunoactivation of immune cells requires multiple incoming signals. Beside antigen recognition, co-stimulatory, survival, and proliferative signals, even environmental factors can determine the outcome of the immune response (1–4).…”

Section: Introductionmentioning

confidence: 99%

Immune Checkpoint Molecules in Reproductive Immunology

et al. 2019

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“…Decreased percentage of TIM-3 expressing-dNK cells and DSCs have been shown in recurrent pregnancy loss patients (38). Conversely an upregulation of TIM-3 has been identified in decidual tissues of preeclamptic women (119). These two pathological pregnancy immune conditions, suggest a disrupted Th1 immune response regulation, due to TIM-3 pathway.…”

Section: Tim-3mentioning

confidence: 96%

Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal–Maternal Interface

Bruno¹,

Corrado

Baci

et al. 2020

Front. Oncol.

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The immune escape mechanisms at the base of tumor progression in endometrial cancer mimic immune tolerance mechanisms occurring at the maternal-fetal interface. The biological and immunological processes behind the maternal-fetal interface are finely tuned in time and space during embryo implantation and subsequent pregnancy stages; conversely, those behind cancer progression are often aberrant. The environment composition at the maternal-fetal interface parallels the pro-tumor microenvironment identified in many cancers, pointing to the possibility for the use of the maternal-fetal interface as a model to depict immune therapeutic targets in cancer. The framework of cancer environment signatures involved in immune adaptations, precisely timed in cancer progression, could reveal a specific "immune clock" in endometrial cancer, which might guide clinicians in patient risk class assessment, diagnostic workup, management, surgical and therapeutic approach, and surveillance strategies. Here, we review studies approaching this hypothesis, focusing on what is known so far about oncofetal similarities in immunity with the idea to individualize personalized immunotherapy targets, through the downregulation of the immune escape stage or the reactivation of the pro-inflammatory processes suppressed by the tumor.

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“…A decreased percentage of Tim-3 + dNK cells with increased Th1-type cytokines was observed in human and mice miscarriages ( 12 ). While, the excessive activation of Tim-3/Gal-9 is related to recurrent spontaneous abortion and preeclampsia ( 64 , 65 ). Therefore, the significance of Gal-9/Tim-3 signal for dNK cells has remained mostly unknown.…”

Section: The Functional Dialogue Between Dnk Cells and Evt Cells At Maternal-fetal Interfacementioning

confidence: 99%

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

et al. 2021

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Decidual natural killer (dNK) cells are the tissue-resident and major subpopulation of NK cells at the maternal-fetal interface. It has been demonstrated that dNK cells play pivotal roles in pregnancy, including keeping maternal-fetal immune tolerance, promoting extravillous trophoblast (EVT) cell invasion, and driving uterine spiral artery remodeling. However, the molecular mechanisms haven’t been elucidated until recent years. In this review, we systemically introduce the generation, subsets, and surface or soluble molecules of dNK cells, which are critical for maintaining the functions of dNK cells. Further, new functions of dNK cells including well-controlled cytotoxicity, immunosurveillance and immunotrophism supporting via the cell-cell interaction between dNK cells and EVT cells are mainly focused. The molecular mechanisms involved in these functions are also illustrated. Moreover, pregnancy-associated diseases caused by the dNK cells abnormalities are discussed. It will be important for future investigations about the mechanism of maintenance of pregnancy and parturition and potential clinical applications of dNK cells.

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Upregulation of the Tim-3/Gal-9 pathway and correlation with the development of preeclampsia

Cited by 30 publications

References 37 publications

Immune Checkpoint Molecules in Reproductive Immunology

Immune Checkpoint Molecules in Reproductive Immunology

Endometrial Cancer Immune Escape Mechanisms: Let Us Learn From the Fetal–Maternal Interface

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

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