Upregulation of the transcription elongation factor ELL2 by Tax as a novel mechanism of HTLV-1 gene expression

Conference Highlights of the 16th International Conference on Human Retrovirology: HTLV and Related Retroviruses, 26–30 June 2013, Montreal, Canada

“…They observed that BAF complexes are regulated by phosphorylation of the Baf 53 subunit, and that PBAF complexes substitute the negative inhibitory BAF complexes needed for activated transcription. Mann et al discovered a novel role for Tax in transcriptional activation involving interaction with an elongation factor [ 194 ]. The positive transcription elongation factor b (pTEFb), which is recruited to the LTR by Tax, requires additional proteins for efficient elongation during transcription.…”