Upregulation of TIMM8A is correlated with prognosis and immune regulation in BC

Lin, Lin; Wu, Yunfei; Bing, Pingping; Zhou, Jun; Yu, Wei

doi:10.3389/fonc.2022.922178

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…However, the role of CEPT1 in oncology is yet to be elucidated. Furthermore, TIMM8A is an oncogene whose upregulation is correlated with poor prognosis in BC [43,44]. However, TIMM8A in OSCC has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Possible Role of miR-375-3p in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

Saika,

Nakashiro,

Tokuzen

et al. 2024

Cancers

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No clinically useful predictors of latent cervical lymph node metastasis (LNM) in early oral squamous cell carcinoma (OSCC) are available. In this study, we focused on the microRNAs (miRNAs) involved in the expression of numerous genes and explored those associated with latent cervical LNM in early OSCC (eOSCC). First, microarray and RT-PCR analyses revealed a significant downregulation of miR-375-3p expression in primary eOSCC tissues with latent cervical LNM. Next, we examined the effects of miR-375-3p mimics on the growth and migration of four human OSCC cell lines that do not express miR-375-3p. The overexpression of miR-375-3p significantly suppressed the cell proliferation and migration of human OSCC cells in vitro. Furthermore, miR-375-3p mimics markedly inhibited the subcutaneously xenografted human OSCC tumors. Finally, we found the genes involved in the PI3K-AKT pathway and cell migration as target gene candidates of miR-375-3p in human OSCC cells. These findings suggest that miR-375-3p functions as a tumor suppressive-miRNA in OSCC and may serve as a potential biomarker for the prediction of latent cervical LNM in eOSCC and a useful therapeutic target to suppress OSCC progression.

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Section: Discussionmentioning

confidence: 99%

Possible Role of miR-375-3p in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

Saika,

Nakashiro,

Tokuzen

et al. 2024

Cancers

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“…Up to date, a large number of studies have uncovered multiple genes can serve as biomarkers for immunotherapy response in BrCa or other cancer types, such as CCDC69 ( Yi et al, 2022 ), TIMM8A ( Zhang et al, 2022b ), and ACE2 ( Mei et al, 2022 ). Most of these studies are lacking real-world cohort validation, which is also the main shortcoming of our current research.…”

Section: Discussionmentioning

confidence: 99%

PSME2 identifies immune-hot tumors in breast cancer and associates with well therapeutic response to immunotherapy

Wu¹,

Ren²,

Sun³

et al. 2022

Front. Genet.

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Breast cancer (BrCa) is a heterogeneous disease, which leads to unsatisfactory prognosis in females worldwide. Previous studies have proved that tumor immune microenvironment (TIME) plays crucial roles in oncogenesis, progression, and therapeutic resistance in Breast cancer. However, biomarkers related to TIME features have not been fully discovered. Proteasome activator complex subunit 2 (PSME2) is a member of proteasome activator subunit gene family, which is critical to protein degradation mediated by the proteasome. In the current research, we comprehensively analyzed the expression and immuno-correlations of Proteasome activator complex subunit 2 in Breast cancer. Proteasome activator complex subunit 2 was significantly upregulated in tumor tissues but associated with well prognosis. In addition, Proteasome activator complex subunit 2 was overexpressed in HER2-positive Breast cancer but not related to other clinicopathological features. Interestingly, Proteasome activator complex subunit 2 was positively related to immune-related processes and identified immuno-hot TIME in Breast cancer. Specifically, Proteasome activator complex subunit 2 was positively correlated with immunomodulators, tumor-infiltrating immune cells (TIICs), immune checkpoints, and tumor mutation burden (TMB) levels. Moreover, the positive correlation between Proteasome activator complex subunit 2 and PD-L1 expression was confirmed in a tissue microarray (TMA) cohort. Furthermore, in an immunotherapy cohort of Breast cancer, patients with pathological complete response (pCR) expressed higher Proteasome activator complex subunit 2 compared with those with non-pathological complete response. In conclusion, Proteasome activator complex subunit 2 is upregulated in tumor tissues and correlated with the immuno-hot tumor immune microenvironment, which can be a novel biomarker for the recognition of tumor immune microenvironment features and immunotherapeutic response in Breast cancer.

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“…Decidual stromal cells have also been proposed as a possible immunomodulatory therapy for individuals with COVID-19 infection. 204,205 Nucleoprotein (NP) is a complicated, incapacitating, long-term pain condition brought on by a somatosensory system injury or illness. Because the underlying illness processes are complex, treating it may not be easy.…”

Section: Immunomodulatory Strategies To Control Neuroinflammationmentioning

confidence: 99%

“…MSC‐based treatment for the control of COVID‐19: MSCs have been shown to have an immunomodulatory impact, which is why MSC‐based treatment has been recommended as one of the therapeutic methods for COVID‐19 management. Decidual stromal cells have also been proposed as a possible immunomodulatory therapy for individuals with COVID‐19 infection 204,205 …”

Section: Therapeutic Approaches and Future Directionsmentioning

confidence: 99%

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

Hakami,

Khan,

Abdulaziz

et al. 2024

Reviews in Medical Virology

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The Varicella‐zoster virus (VZV), classified as a neurotropic member of the Herpesviridae family, exhibits a characteristic pathogenicity, predominantly inducing varicella, commonly known as chickenpox, during the initial infectious phase, and triggering the reactivation of herpes zoster, more commonly recognized as shingles, following its emergence from a latent state. The pathogenesis of VZV‐associated neuroinflammation involves a complex interplay between viral replication within sensory ganglia and immune‐mediated responses that contribute to tissue damage and dysfunction. Upon primary infection, VZV gains access to sensory ganglia, establishing latent infection within neurons. During reactivation, the virus can spread along sensory nerves, triggering a cascade of inflammatory mediators, chemokines, and immune cell infiltration in the affected neural tissues. The role of both adaptive and innate immune reactions, including the contributions of T and B cells, macrophages, and dendritic cells, in orchestrating the immune‐mediated damage in the central nervous system is elucidated. Furthermore, the aberrant activation of the natural defence mechanism, characterised by the dysregulated production of immunomodulatory proteins and chemokines, has been implicated in the pathogenesis of VZV‐induced neurological disorders, such as encephalitis, myelitis, and vasculopathy. The intricate balance between protective and detrimental immune responses in the context of VZV infection emphasises the necessity for an exhaustive comprehension of the immunopathogenic mechanisms propelling neuroinflammatory processes. Despite the availability of vaccines and antiviral therapies, VZV‐related neurological complications remain a significant concern, particularly in immunocompromised individuals and the elderly. Elucidating these mechanisms might facilitate the emergence of innovative immunomodulatory strategies and targeted therapies aimed at mitigating VZV‐induced neuroinflammatory damage and improving clinical outcomes. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of VZV infections.

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Upregulation of TIMM8A is correlated with prognosis and immune regulation in BC

Cited by 7 publications

References 24 publications

Possible Role of miR-375-3p in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

Possible Role of miR-375-3p in Cervical Lymph Node Metastasis of Oral Squamous Cell Carcinoma

PSME2 identifies immune-hot tumors in breast cancer and associates with well therapeutic response to immunotherapy

Varicella‐zoster virus‐related neurological complications: From infection to immunomodulatory therapies

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