Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway

Vulgarisin-type diterpenoids from self-heal (Prunella vulgaris) and their neuroprotective effects against ischemia/reperfusion (I/R) via a mitochondria-related pathway

“…21,22 P. vulgaris is rich in terpenoids, especially triterpenoids. [23][24][25] However, several studies have reported that the triterpenoid acids from P. vulgaris exhibit pro-apoptosis activity, [26][27][28] which is inconsistent with our preliminary experimental results. Our preliminary experiment has revealed that the ethanol extracts of P. vulgaris possess considerable neuroprotective effects (data not shown).…”

Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO3nanoparticles for synergistic chemotherapy

“…OA significantly attenuated CDDP-induced NF-κB activation reported previously by our group, 27 leading to the regulation of inflammatory cytokines release and ultimately the nephroprotection. 50,51…”

“…OA signicantly attenuated CDDP-induced NF-kB activation reported previously by our group, 27 leading to the regulation of inammatory cytokines release and ultimately the nephroprotection. 50,51 Hence, we can say that OA addition to the CDDP combination chemotherapy in our system (CDDP/OA-LCC NPs) makes it an ideal therapy for combating nephrotoxicity in patients receiving CDDP chemotherapy.…”

Oxybaphus himalaicus Mitigates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting TLR4/MD2 Complex Formation

“…Among these compounds, reynosin (PubChem CID 482788) was revealed to decrease inflammatory cytokine release. Carabrol (PubChem CID 15690483) and ursolic acid (PubChem CID 64945) were reported to exert an anti-inflammatory effect by inhibiting NF-κB activation [ 49 , 50 ]. (+/−)-Abscisic acid (PubChem CID 5375199) was found to suppress NLRP3 inflammasome and NF-κB activation to ameliorate inflammation [ 51 , 52 ].…”