Upregulation of α2-adrenoceptor synthesis in SHR cardiomyocytes: Recompense without sense – Increased amounts, impaired commands

Kokoz, Yu. M.; Evdokimovskii, Edward V.; Maltsev, Alexander V.

doi:10.1016/j.abb.2019.108109

Cited by 7 publications

(2 citation statements)

References 41 publications

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“…It should be noted that age-related features were observed by us in previous in vivo and in vitro experiments [6,14,15]. The opposite effects induced by different concentrations of α2-AR agonist can be explained by the participation of different subtypes of α2-AR with different functional activity in the regulation of the heart, as well as differences in presynaptic and postsynaptic α2-AR signal transmission [6][7][8]14].…”

Section: Resultsmentioning

confidence: 92%

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Effect of Clonidine Hydrochloride on Isolated Newborn Rat Heart

et al. 2021

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The concentration dependenies of the chronotropic response and changes in blood supply to the isolated heart of 7-day-old newborn rats induced by application of α2-adrenergic receptor agonist clonidine hydrochloride in concentrations of 10 -9 -10 -6 M were revealed. The minimum concentration of α2-adrenergic receptor agonist caused tachycardia, while higher concentrations led to bradycardia. The maximum effect manifesting in a decrease in coronary flow was recorded at the minimum concentration of the agonist, while the highest concentration had no effect on the coronary flow. When comparing these results with those obtained in control adult rats, we found that the most pronounced differences in the chronotropic effects were observed after addition of the minimum concentration of the α2-adrenergic receptor agonist: bradycardia in adult rats and tachycardia in newborns. The maximum differences in coronary flow parameters were observed after addition of α2-adrenergic receptor agonist in the maximum concentration that induced a two-phase response in adult rats and had no effect on the blood supply in newborns.

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Section: Resultsmentioning

confidence: 92%

“…The presence of α2A-AR, α2B-AR and α2C-AR was shown in the myocardial sarcolemma. In cardiomyocytes, α2-AR activation causes signaling through PI3 kinase and protein kinase B, which leads to an increase in NO production and a decrease in the level of intracellular Ca 2+ [7,8].…”

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confidence: 99%