2021
DOI: 10.1101/2021.12.23.474019
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Upstream charged and hydrophobic residues impact the timing of membrane insertion of transmembrane helices

Abstract: During SecYEG-mediated cotranslational insertion of membrane proteins, transmembrane helices (TMHs) first make contact with the membrane when their N-terminal end is ~45 residues away from the peptidyl transferase center. However, we recently uncovered instances where the first contact is delayed by up to ~10 residues. Here, we recapitulate these effects using a model TMH fused to two short segments from the BtuC protein: a positively charged loop and a re-entrant loop. We show that the critical residues are t… Show more

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