Uptake and rate of metabolism of vinyl chloride by the isolated perfused rat liver preparation

Radwan, Z.; Henschler, D.

doi:10.1007/bf00575154

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Metabolism1

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1978

1984

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Cited by 6 publications

(2 citation statements)

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“…Chloroethylene oxide, which transforms spontaneously into chloroacetaldehyde, is proposed as the primary reactive intermediate (Gross and Freiberg, 1969) and indirect evidence for its formation exists in vitro (Barbin et al, 1975;Gothe et al, 1974) and in vivo (Muller et al, 1978). Pretreatment of the animals with mixed-functionoxidase inhibitors such as 6-bromobenzothiazine (Radwan and Henschler, 1977), CoCh (Pessayre et al, 1979), or 3-bromophenyl-4-(5)imidazole , inhibited VCM metabolism.…”

Section: Metabolismmentioning

confidence: 89%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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Section: Metabolismmentioning

confidence: 89%

Mutagenicity, Carcinogenicity, and Teratogenicity of Industrial Pollutants

Kirsch‐Volders¹

1984

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“…This was confirmed in 1974 by Hefner and co-work-* Universitat Dusseldorf, Dusseldorf, W. Germany. ers (3) and in 1975 by Radwan and Henschler (4).…”

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confidence: 99%

Studies on the metabolism of vinyl chloride.

Antweiler¹

1976

Environ Health Perspect

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Vinyl chloride (VCM) is not carcinogenic by itself, it is bioactivated to the highly reactive alkylating oxirane chloroethylene oxide. Further metabolism, apparently, leads via an interaction of the primary alkylating metabolites with glutathion to S-(2-carboxy-methyl)-cysteine and thiodiacetic acid which are eliminated with the urine. Up to now, it has not been ascertained whether the oxirane alone is the essential carcinogenic factor or whether other metabolites are also involved in carcinogenicity. Likewise, it is still unknown whether the metabolites excreted in the urine might be used as biological criteria for exposure to VCM, because these metabolites probably can originate from a series of substances other than VCM. This problem could stimulate investigations on the possible carcinogenic activity of these substances.

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