Uptake and release of Dexamethasone using pH-responsive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) hydrogels for potential use in ocular drug delivery

Faccia, Paula Andrea; Pardini, Francisco Martín; Amalvy, Javier Ignacio

doi:10.1016/j.jddst.2019.02.018

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…3− and -N(R) 2 H + have been reported [109], as well as through intercalation into layered double hydroxides (LDHs) in which strong electrostatic interactions have been detected [110]. However, such interactions have not been detected in our nanoparticles and the drug amorphization should be due to the high DexSP solubility and probably due to its fine dispersion into the nanoparticles.…”

Section: Characterization Of Drug-loaded Nanoparticlesmentioning

confidence: 74%

“…Usually, when interactions are taking place between a polymer and a drug, as in the case of hydrogen bonding between chloramphenicol and poly(vinyl pyrrolidone) (PVP), poly(vinyl alcohol) and Eudragit ® [ 108 ], amorphous dispersions are produced. In the case of dexamethasone, some interactions with polymers through hydrogen bonding or ionic bonds between PO 4 3 − and –N(R) 2 H + have been reported [ 109 ], as well as through intercalation into layered double hydroxides (LDHs) in which strong electrostatic interactions have been detected [ 110 ]. However, such interactions have not been detected in our nanoparticles and the drug amorphization should be due to the high DexSP solubility and probably due to its fine dispersion into the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

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Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

et al. 2020

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The aim of this work was to evaluate the effectiveness of neat chitosan (CS) and its derivatives with 2-acrylamido-2-methyl-1-propanesulfonic acid (AAMPS) and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (MEDSP) as appropriate nanocarriers for the simultaneous ocular administration of dexamethasone sodium phosphate (DxP) and chloramphenicol (CHL). The derivatives CS-AAMPS and CS-MEDSP have been synthesized by free-radical polymerization and their structure has been proved by Fourier-Transformed Infrared Spectroscopy (FT-IR) spectroscopy. Both derivatives exhibited low cytotoxicity, enhanced mucoadhesive properties and antimicrobial activity against Staphylococcus aureus (S.aureus) and Escherichia coli (E. coli). Encapsulation was performed via ionic crosslinking gelation using sodium tripolyphosphate (TPP) as the crosslinking agent. Dynamic light scattering measurements (DLS) showed that the prepared nanoparticles had bimodal distribution and sizes ranging from 50–200 nm and 300–800 nm. Drugs were encapsulated in their crystalline (CHL) or amorphous (DexSP) form inside nanoparticles and their release rate was dependent on the used polymer. The CHL dissolution rate was substantially enhanced compared to the neat drug and the release time was extended up to 7 days. The release rate of DexSP was much faster than that of CHL and was prolonged up to 3 days. Drug release modeling unveiled that diffusion is the main release mechanism for both drugs. Both prepared derivatives and their drug-loaded nanoparticles could be used for extended and simultaneous ocular release formulations of DexSP and CHL drugs.

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Section: Characterization Of Drug-loaded Nanoparticlesmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

et al. 2020

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“…HEMA is a small monomer with widespread use, not only in dentistry but also in medical applications because of its relatively excellent biocompatibility 20. A key characteristic of HEMA is hydrophilicity, which makes it an excellent adhesion‐promoting monomer 21–25. It could promote the wettability of biomaterials as well as significantly improved bond strengths 26.…”

Section: Introductionmentioning

confidence: 99%

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Chen

Tang

Zhao

et al. 2020

Macro Materials & Eng

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Although the shrinkage of polymethyl methacrylate (PMMA) bone cement has been tackled by the poly(methyl methacrylate‐co‐acrylic acid) [P(MMA‐AA)] bone cement due to the expandable P(MMA‐AA) copolymer in the solid phase, the hydrophobicity of PMMA and its solidification restrict simulated body fluid (SBF) diffusion and expansion properties. In this research, hydroxyethyl methacrylate (HEMA)‐modified P(MMA‐AA) bone cement (HMBC) is obtained by introducing HEMA into the liquid phase of P(MMA‐AA) bone cement. It is assumed that the dual water absorption networks can promote the SBF absorption capacity, thus resulting in the increased expansion behavior. The results demonstrate that the introduction of HEMA improves the hydrophilicity of the bulk. SBF absorption efficiency and swelling efficiency are promoted in the primary step of expansion. The porous structure of HMBC contributes to the increased SBF absorption and swelling in the second step of expansion behavior. Meanwhile, the remarkable absorption ratio and expansion ratio reach 88.5% and 97.4%, respectively. Furthermore, enhanced biocompatibility and osteogenesis activity provide HMBC as a promising biomaterial in the clinical setting.

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“…Combined with the electrostatic repulsion force, the dissociation of hydrogen bonds makes the hydrogel network swell rapidly. Therefore, the hydrogels are immersed in more water and a higher swelling ratio is obtained [33].…”

Section: Resultsmentioning

confidence: 99%

Nifedipine, Niclosamide and Furosemid Release of A Biocompatible and Protective Hydrogel for Cancer Therapy

Yılmaz¹

2021

Preprint

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In this work, biocompatible and protective pure HEMA hydrogel structures and drug loaded HEMA hydrogel have been successfully synthesized. The hydrogel was prepared using HEMA, MBA, APS and TEMED. The structural and morphological characterization of pure hydrogel and drug-loaded hydrogels were characterized using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM), respectively. The pH affinity, morphology, structure, drug release, swelling and cytotoxic effect of the resulting materials were studied in detail. Drug releases of drug-loaded hydrogel structures were measured at certain time intervals and recorded as cumulatively (%). In addition, cytotoxicity tests were performed by Alamar blue method on MCF-7, MIA PaCa-2 and HEK 293 cell lines of released drug molecules. This HEMA hydrogel was suggested to be materials of biological attention and of large pharmacological potential as support material in drug release of nifedipine, furosemide, niclosamide and similar drug molecules.

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Uptake and release of Dexamethasone using pH-responsive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) hydrogels for potential use in ocular drug delivery

Cited by 21 publications

References 35 publications

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

Chitosan Derivatives with Mucoadhesive and Antimicrobial Properties for Simultaneous Nanoencapsulation and Extended Ocular Release Formulations of Dexamethasone and Chloramphenicol Drugs

HEMA‐Modified Expandable P(MMA‐AA) Bone Cement with Dual Water Absorption Networks

Nifedipine, Niclosamide and Furosemid Release of A Biocompatible and Protective Hydrogel for Cancer Therapy

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