Uptake and Release of Dexamethasone Phosphate From Silicone Hydrogel and Group I, II, and IV Hydrogel Contact Lenses

Boone, Adrienne N.; Hui, Alex; Jones, Lyndon

doi:10.1097/icl.0b013e3181b26c49

Cited by 71 publications

(55 citation statements)

References 42 publications

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“…516.4) in 10 μl of tears, would theoretically be almost 9.3 mM, which is about five times higher than the concentration provided in the commercially available eye drops. The results presented here are in agreement with an earlier report involving the loading of DXP in pHEMA lenses, where a maximum of 3.9 mM DXP release was achieved and warranted to be clinically relevant and within the therapeutic index [9]. Further, looking at the 10 days release profile, the amount of DXP released was about 4.3 μg/day.…”

Section: Synthesis and Characterization Of Nanoparticle-laden Phema Csupporting

confidence: 93%

“…In relation to their use as drug delivery vehicles, simple drug-soaking methods, which have been applied in an effort to incorporate drugs into contact lenses, have traditionally proven unsuitable, in particular for highly hydrophilic drugs such as dexamethasone sodium phosphate [9]. In an effort to develop contact lenses capable of such use, a range of technologies have been applied, including molecular imprinting, an approach pioneered by Byrne et al [5,10].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

et al. 2016

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Section: Synthesis and Characterization Of Nanoparticle-laden Phema Csupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

et al. 2016

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“…Regrettably, the current in vitro models for testing CLs are rudimentary and lack several key components to adequately mimic the in vivo environment. For instance, in vitro CL studies are performed in vials containing 2-5 ml of phosphate buffered saline, [1][2][3][4][5][6] which greatly exceeds physiological tear volumes at 7.0 ± 2 µl. 7 Moreover, two important factors of the ocular environment, natural tear flow and the blinking reflex, are absent from the simple static vial model.…”

Section: Discussionmentioning

confidence: 99%

Development of an <em>In Vitro</em> Ocular Platform to Test Contact Lenses

Phan

Walther

Gao

et al. 2016

JoVE

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Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials, 1-6 which fail to mimic physiological tear volumes. 7 The traditional model also lacks the natural tear flow component and the blinking reflex, both of which are defining factors of the ocular environment. The development of a novel model is described in this study, which consists of a unique 2-piece design, eyeball and eyelid piece, capable of mimicking physiological tear volume. The models are created from 3-D printed molds (Polytetrafluoroethylene or Teflon molds), which can be used to generate eye models from various polymers, such as polydimethylsiloxane (PDMS) and agar. Further modifications to the eye pieces, such as the integration of an explanted human or animal cornea or human corneal construct, will permit for more complex in vitro ocular studies. A commercial microfluidic syringe pump is integrated with the platform to emulate physiological tear secretion. Air exposure and mechanical wear are achieved using two mechanical actuators, of which one moves the eyelid piece laterally, and the other moves the eyeballeyepiece circularly. The model has been used to evaluate CLs for drug delivery and deposition of tear components on CLs. Video LinkThe video component of this article can be found at

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“…The data and interpretation presented here are consistent with, and offer an interpretive basis for the passive uptake and release studies involving a wide range of ophthalmic drugs and commercial lenses presented by Jones and co-workers. [31][32][33] …”

Section: Structural Links Between Ophthalmic Dyes and Ophthalmic Drugsmentioning

confidence: 99%

“…[31][32][33][34][35] Although such experiments are extremely useful in providing baseline diffusional studies they do not address fundamental aspects in sufficient detail.…”

Section: Introductionmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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The poor retention and efficacy of instilled drops as a means of delivering drugs to the ophthalmic environment is well-recognised. The potential value of contact lenses as a means of ophthalmic drug delivery and consequent improvement of pre-corneal retention is one obvious route to the development of a more effective ocular delivery system. Furthermore, the increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable single-day use drug delivery devices based on existing materials and lenses. In order to provide a basis for the effective design of such devices, a systematic understanding of the factors affecting the interaction of individual drugs with the lens matrix is required. Because a large number of potential structural variables are involved it is necessary to achieve some rationalisation of the parameters and physicochemical properties (such as molecular weight, charge, partition coefficients) that influence drug interactions. Ophthalmic dyes and structurally related compounds based on the same core structure were used to investigate these various factors and the way in which they can be used in concert to design effective release systems for structurally different drugs. Initial studies of passive diffusional release form a necessary precursor to the investigation of the features of the ocular environment that over-ride this simple behaviour. Commercially available contact lenses of differing structural classifications were used to study factors affecting the uptake of the surrogate actives and their release under "passive" conditions. The interaction between active and lens material shows considerable and complex structure dependence which is not simply related to equilibrium water content (EWC). The structure of the polymer matrix itself was found to have the dominant controlling influence on active uptake; hydrophobic interaction with the ophthalmic dye playing a major role.3

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Uptake and Release of Dexamethasone Phosphate From Silicone Hydrogel and Group I, II, and IV Hydrogel Contact Lenses

Abstract: Although most of the lenses released enough drug to have anti-inflammatory action, none of the materials released drug for a long enough period of time to be clinically useful as a drug delivery device.

Cited by 71 publications

References 42 publications

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

Synthesis and Characterization of Poly(2-hydroxyethylmethacrylate) Contact Lenses Containing Chitosan Nanoparticles as an Ocular Delivery System for Dexamethasone Sodium Phosphate

Development of an <em>In Vitro</em> Ocular Platform to Test Contact Lenses

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

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