Uptake, distribution and elimination of styrene in man. Concentration in subcutaneous adipose tissue.

Engström, Jörgen; Bjurström, Rasmus; Åstrand, Irma; Övrum, Per

doi:10.5271/sjweh.2694

Cited by 58 publications

(29 citation statements)

References 14 publications

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“…The regression line does not start from the origin of the Cartesian coordinates but intercepts the y axis at 154 nmolll ( figure 3 and 6); this finding indicates that at the beginning of the exposure period there was some styrene in the blood of the subjects under study, as expected and previously documented (9,10).…”

Section: Stagesupporting

confidence: 69%

“…Under such conditions, R values being equal, the amounts of styrene taken up are clearly larger (depending on pulmonary ventilation), and greater solvent concentrations are therefore reached in arterial blood (10), and consequently greater urinary concentrations as well. Th e four regression lines star t pract ically from the origin of the Car tesian coordinates (figure 5) (intercepts o f the y axis between -2.6 and 21.7 nmo lll) because the subjects under study had never been exposed to styrene previously.…”

Section: Stagementioning

confidence: 94%

“…This occurrence was probably due to a continuous increase in styrene concentration in arterial blood from the beginning of exposure up to I h or more later (6,10,37,38).…”

Section: Stagementioning

confidence: 99%

“…General studies have been devoted to its uptake (1,37), distribution in body tissues (6,10), and elimination as urinary metabolites (mandelic and phenylglyoxylic acids) (11, 12,21 ,28). It is a substance easily soluble in the blood and biological tissues and therefore probably accumulates with each consecutive exposure (9,10).…”

mentioning

confidence: 99%

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Urinary elimination of styrene in experimental and occupational exposure.

Pezzagno¹,

Ghittori²,

Imbriani³

et al. 1985

Scand J Work Environ Health

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PEZZAGNO G, GHITTORI S, IMBRIANI M, CAPODAGLIO E. Urinary elimination of styrene in experimental and occupational exposure. Scand J Work En viron Health II (1985) 371-379. Twentyhuman volunteers were exposed to styrene vapor at 273-1 654 !tmol/m' (28.4-172.3 mg/m') for a period of 1 to 3 h at rest (15cases)and during light physical exercise (5 cases).Subsequently51 workers occupationally exposed to styrenewerestudied during a workweek (medianvalue 1 138!tmol/m', geometric standard deviation 2.23). As expected, the relative uptake averagedabout 65 lifo, and the ratio of the alveolar concentration to the time-weighted average of the environmental concentration averaged about 0.15. Both in the experimentally exposedsubjects and in the occupationallyexposedworkers the urinary styreneconcentration showed a linear relationship to the corresponding environmental time-weighted average concentration. The correlation coefficients of the regression lines ranged between 0.88 (occupationally exposed group) and more than 0.93 (experimentally exposedgroups). The regression coefficients wereclosely linked to the amount of styrene taken up and to the exposure times. The findings show that the urinary styrene concentration can be used as an appropriate biologicalexposure indicator whosemeaning differs from that of other suggested indices. As an example, in occupationally exposed subjectsperforming moderate work the urinary styreneconcentration correspondingto the time-weighted average of the threshold limit value is 815 nmol/I, and the 95 0J0 lower confidence limit (biological threshold) is 740 nmol/1.

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Section: Stagesupporting

confidence: 69%

Section: Stagementioning

confidence: 94%

“…This occurrence was probably due to a continuous increase in styrene concentration in arterial blood from the beginning of exposure up to I h or more later (6,10,37,38).…”

Section: Stagementioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Urinary elimination of styrene in experimental and occupational exposure.

Pezzagno¹,

Ghittori²,

Imbriani³

et al. 1985

Scand J Work Environ Health

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show abstract

“…The elimination of these solvents from adipose tissue in man is relatively slow (1,8,9,10,11,12), a phenomenon indicating a potential risk of prolonged exposure to such lipophilic solvents. In the present study mice were exposed to acetone, as it is of interest to compare the distribution and elimination pattern of the highly water-soluble acetone (19) with those of the earlier studied lipophilic organic solvents.…”

Section: Reprint Requests To: Ms E Wigaeus Researchmentioning

confidence: 99%