1991
DOI: 10.1016/0045-6535(91)90323-6
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Uptake, elimination, and bioconcentration of ten anilines in zebrafish (Brachydanio rerio)

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Cited by 26 publications
(11 citation statements)
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“…Deviations from the expected values are within 0.5 log units for most chemicals and at least within one order of magnitude for all chemicals except 2,4-dichloroaniline. Log k e,norm of 2,4dichloroaniline was extremely small compared with other structurally similar compounds [21]. The extraordinarily slow elimination rate of 2,4-dichloroaniline could not be explained by passive diffusion processes.…”
Section: Comparison Of Uptake/elimination Rate Constants In Fish Withmentioning
confidence: 70%
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“…Deviations from the expected values are within 0.5 log units for most chemicals and at least within one order of magnitude for all chemicals except 2,4-dichloroaniline. Log k e,norm of 2,4dichloroaniline was extremely small compared with other structurally similar compounds [21]. The extraordinarily slow elimination rate of 2,4-dichloroaniline could not be explained by passive diffusion processes.…”
Section: Comparison Of Uptake/elimination Rate Constants In Fish Withmentioning
confidence: 70%
“…Thus, the extremely low permeability of 2, 4‐dinitroaniline and 4‐nitroaniline could be because of their strong dipole moments. In spite of their electrical properties, absorption rate constants of nitroanilines are similar to those of aniline and chloroanilines [21]. Relatively high absorption rate constants by fish indicate that uptake of nitroanilines by fish might not be described by passive diffusion across a series of biological barriers.…”
Section: Discussionmentioning
confidence: 99%
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“…Three hundred and thirty seven experimental BCFs in fish were collected from the literature (8,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) …”
Section: Experimental Bcf Collectionmentioning
confidence: 99%
“…P450 gene has been described; the CYPIA1 from rainbow trout, Oncorhynchus mykiss (2,3). A detailed comparison of microsomal aniline hydroxylation in different tissues of rats (4), guinea pigs (4), rabbits (4,5), and sheep (6) was made; however, the toxicity of aniline or its derivatives has been determined for few fish species (7,8), and the biotransformation of these compounds were investigated previously (7)(8)(9)(10)(11)(12)(13). Aniline hydroxylation by cytochrome P450-dependent enzyme systems has been shown to be a possible way for metabolism in the liver of fish species, and the aniline hydroxylase is known to be a member of mixed-function oxidases catalyzing transformation of toxic aniline to nontoxic p-aminophenol.…”
Section: Introductionmentioning
confidence: 99%