Uptake of 14c-Dopamine in Platelets of Huntington's Chorea Patients and Symptom-Free Offspring

Huntington disease is a neurological autosomal dominant disease of unknown origin and the search for a suitable diagnostic marker has been extended to the peripheral tissues. It is generally believed that a membrane defect exists in Huntington disease although the evidence is controversial. It is the aim of this review to examine the validity of these claims for each of the peripheral tissues and techniques involved, and it is not intended to include all other aspects of research into Huntington disease.

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Abnormal platelet aggregation response in Huntington's disease

Muramatsu

Kaiya

Imai

et al. 1982

Arch. F. Psychiatr. U. Z. Neur.

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Platelet aggregation response to epinephrine, dopamine, serotonin, adenosine diphosphate, arachidonic acid, and collagen was examined in seven patients with Huntington's disease and nine of their relatives. All patients, except for two cases that were in terminal states, showed enhanced response to all the stimulants, especially to dopamine and epinephrine. The platelet aggregation response in many relatives also deviated from the normal limit. The relationship between platelet aggregation abnormality in Huntington's disease and the pathophysiology of the disease was discussed from the view of a generalized membrane defect hypothesis in Huntington's disease, and of disturbed cathecholamine metabolism, both in the CNS and periphery. A possibility that platelet aggregation response examination will be a useful screening test of offspring at risk was proposed.

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Uptake of 14c-Dopamine in Platelets of Huntington's Chorea Patients and Symptom-Free Offspring

Cited by 6 publications

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Presymptomatic and early detection in Huntington's disease

Presymptomatic and early detection in Huntington's disease

The current state of research with peripheral tissues in Huntington disease

Abnormal platelet aggregation response in Huntington's disease

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