Uptake of 28 Mg and 45Ca by tissues of magnesium-deficient rabbits

Woodward, DL; Dj, Reed

doi:10.1152/ajplegacy.1969.217.5.1483

Cited by 8 publications

(2 citation statements)

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“…Mg-28 has been employed since its discovery in 1953 for metabolic investigations in plants [24][25][26]. Followed by analogous studies on animals' physiology and metabolism for several decades [27][28][29][30][31][32][33][34][35][36][37][38]. The intrigue surrounding Mg-28's application for studying Mg's pathology, absorption, excretion, and metabolic dynamics within the human body has also captured researchers' attention [39][40][41][42][43][44][45][46][47].…”

Section: Overviewmentioning

confidence: 99%

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2023

Japan J Med Sci

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In this study, we have introduced a novel approach to cancer treatment involving the deactivation of metalloenzymes through the utilization of radioisotopes. The concept of leveraging radioisotopes to interact with metalloenzymes represents a groundbreaking theoretical advancement. Through simulations utilizing the MIRD code and based on the consistent concentration of stable Mg within stage 2A cancerous tissue, we have quantified the potential success rates.To conduct these simulations, we employed 0.1 nanograms (ng) of stable Mg, which corresponds to an activity of 19.7 MBq of Mg-28 radioisotope. This data was input into the MIRD calculations to estimate the absorbed doses within various organs, employing diverse methods of radioisotope administration into the body. Remarkably, even with a mere 0.1% probability of effectively reaching the intended cancerous tissues, this quantity of Mg-28 demonstrates the capability to render billions of Mg-containing metalloenzymes inactive.The remarkable efficiency achieved through precise radioisotope targeting underscores the promise of this methodology. Nevertheless, the findings underscore the necessity of undertaking both in vitro and in vivo research initiatives prior to embarking on clinical trials.

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Section: Overviewmentioning

confidence: 99%

Untitled

2023

Japan J Med Sci

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“…The total energy of beta particles emitted from the Mg-28 isotope is Qβ=1830.77 KeV [23], and with a maximum range of 0.36 cm, the calculation yields an average linear energy transfer (LET) of beta particles from Mg-28 at 0.508 KeV/µm or 0.508 eV/nm. Mg-28 has been employed since its discovery in 1953 [23] for metabolic investigations in plants [24-26], followed by analogous studies on animals' physiology and metabolism for several decades [27][28][29][30][31][32][33][34][35][36][37][38]. The intrigue surrounding Mg-28's application for studying Mg's pathology, absorption, excretion, and metabolic dynamics within the human body has also captured researchers' attention [39][40][41][42][43][44][45][46][47].…”

Section: Overviewmentioning

confidence: 99%

Nuclear Transformation In Metalloenzyme. A Novel And High Potential Cancer Treatment Research

Van Luyen,

Tuan

2023

Preprint

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In this study, we have introduced a novel approach to cancer treatment involving the deactivation of metalloenzymes through the utilization of radioisotopes. The concept of leveraging radioisotopes to interact with metalloenzymes represents a groundbreaking theoretical advancement. Through simulations utilizing the MIRD code and based on the consistent concentration of stable Mg within stage 2A cancerous tissue, we have quantified the potential success rates. To conduct these simulations, we employed 0.1 nanograms (ng) of stable Mg, which corresponds to an activity of 19.7 MBq of Mg-28. This data was input into the MIRD calculations to estimate the absorbed doses within various organs, employing diverse methods of radioisotope administration into the body. Remarkably, even with a mere one thousandth probability of effectively reaching the intended cancerous tissues, this quantity of Mg-28 demonstrates the capability to render billions of Mg-containing metalloenzymes inactive. The remarkable efficiency achieved through precise radioisotope targeting underscores the promise of this methodology. Nevertheless, the findings underscore the necessity of undertaking both in vitro and in vivo research initiatives prior to embarking on clinical trials.

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Uptake of magnesium into the brain of the rat

Chutkow

1978

Experimental Neurology

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Uptake of 28 Mg and 45Ca by tissues of magnesium-deficient rabbits

Cited by 8 publications

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Nuclear Transformation In Metalloenzyme. A Novel And High Potential Cancer Treatment Research

Uptake of magnesium into the brain of the rat

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