Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET

Havu-Aurén, Katja; Kiiski, Johanna; Lehtiö, Kaisa; Eskola, Olli; Kulvik, Martti; Vuorinen, Ville; Oikonen, Vesa; Vähätalo, Jyrki; Jääskeläinen, Juha E.; Minn, Heikki

doi:10.1007/s00259-006-0154-y

Cited by 25 publications

(15 citation statements)

References 17 publications

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“…For these purposes, numerous authors have used 18 F-BPA-PET prior to employing BPA-based BNCT, and reported its usefulness (11)(12)(13)(14). However, the possibility of detecting the spatial localization of the tumor as well as delineation of normal anatomical structures has yet to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

Fluorine-18-labeled boronophenylalanine positron emission tomography for oral cancers: Qualitative and quantitative analyses of malignant tumors and normal structures in oral and maxillofacial regions

et al. 2011

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Abstract. The present study aimed to demonstrate the features of fluorine-18-labeled boronophenylalanine positron emission tomography ( 18 F-BPA-PET) to reveal oral cancer, as well as normal structures in the oral and maxillofacial regions. We analyzed 18 F-BPA-PET findings from 8 patients with histologically confirmed recurrent and/or advanced oral cancer scheduled for boron neutron capture therapy. The capacity of 18 F-BPA-PET to delineate tumor and normal structures was assessed qualitatively and quantitatively. Tumors were easily identified as high uptake areas in all cases. Although the eyes, which were depicted as a low uptake area, and tongue musculature were readily identified, major vessels were not noted in any of the cases. Areas corresponding to the surface of the dorsum tongue to middle pharynx were expressed as high uptake areas in all of the cases. Quantitatively, tumors were expressed as the highest uptake area in 6 of the 8 cases, while the dorsum tongue had the highest uptake area in the remaining 2 cases.18 F-BPA-PET is useful in demonstrating the presence of a tumor. Thus, it is crucial to note the presence of a high uptake area corresponding to the dorsum area of the tongue when diagnosing a tumor using this technique. IntroductionFluorodeoxyglucose (FDG) positron emission tomography (PET) has recently become widely used for detecting malignant tumors of the oral cavity, particularly for the diagnosis of metastatic deposits (1). In addition, another type of PET method, methionine-basis PET, has been shown to be useful for diagnosing malignancies (2).Boron neutron capture therapy (BNCT) was recently performed in order to regulate non-resectable advanced and/or recurrent oral cancers, and its clinical utility was previously reported (3,4). However, certain patients suffer from alopecia and/or mucositis after undergoing BNCT (3,5). For planning, as well as predicting the outcome and adverse effects of this therapy, boron concentrations should be evaluated in surrounding normal structures as well as in the tumor itself, for which fluorine-18-labeled boronophenylalanine ( 18 F-BPA) PET was utilized. To the best of our knowledge, features of normal tissues and tumors in 18 F-BPA-PET images have yet to be adequately assessed. The present study therefore aimed to qualitatively and quantitatively elucidate the features of normal structures in the oral and maxillofacial regions, as well as associated tumors revealed by 18 F-BPA-PET imaging. Materials and methodsThe study evaluated 18 F-BPA-PET images obtained in examinations of 8 patients with histologically confirmed recurrent and/or advanced oral cancer, or metastatic lymphadenopathy who were scheduled for BNCT (Table I). Seven of the patients were treated with a combination of surgery, chemotherapy and radiotherapy, while 1 patient was treated with thermotherapy. All PET examinations were performed using an ECAT ACCEL (Siemens Japan Co., Tokyo, Japan) with 18 F-labeled BPA (37-55.5 MBq/10 kg of body weight) injected 45 min prior to obtaining the im...

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Section: Discussionmentioning

confidence: 99%

Fluorine-18-labeled boronophenylalanine positron emission tomography for oral cancers: Qualitative and quantitative analyses of malignant tumors and normal structures in oral and maxillofacial regions

et al. 2011

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“…PET was carried out with either a GE Advance or a GE Discovery STE scanner (GE Medical Systems, Milwaukee, WI) operated in three-dimensional (3D) mode by use of intravenously administered 18 F-fluoro-L-BPA at activity of 160 to 240 MB as the tracer (17). Tumor-to-normal tissue ratios were measured from static emission scans obtained 20 to 40 minutes after 18 F-fluoro-L-BPA injection.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

Kankaanranta

Seppälä

Koivunoro

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

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219

182

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“…Following a similar approach, recent applications have demonstrated the potential of PET imaging for the assessment of BPA accumulation in lesions different from high grade glioma. 18 F-BPA has been used in recurrent cancer in the oral cavity and cervical lymph node metastasis (2007) [117], low grade brain tumors, such as schwannoma and meningioma (2006) [118], head and neck malignancies (2005) [30] and metastatic malignant melanoma (2003) [119]. These early clinical findings with 18 F-BPA/PET led to study the transport and the net influx and accumulation of BPA, and to show the capability of PET to screen the different types and different grades of tumor lesions as candidates for BNCT [120].…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)

Wittig

Michel

Moss

et al. 2008

Critical Reviews in Oncology/Hematology

126

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Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET

Abstract: [(18)F]FBPA PET offers a viable means to evaluate BPA uptake in meningiomas and schwannomas in NF2. Based on our results on tumour uptake of [(18)F]FBPA, some of these benign neoplasms may be amenable to BNCT.

Cited by 25 publications

References 17 publications

Fluorine-18-labeled boronophenylalanine positron emission tomography for oral cancers: Qualitative and quantitative analyses of malignant tumors and normal structures in oral and maxillofacial regions

Fluorine-18-labeled boronophenylalanine positron emission tomography for oral cancers: Qualitative and quantitative analyses of malignant tumors and normal structures in oral and maxillofacial regions

Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial

Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)

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