Uptake of 75-selenium into the central nervous system of the rat

Pullen, R. G. L.; Schofield, M.; Markham, Anthony; Lough, John; Menton, K.

doi:10.1007/bf00995376

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…Se has long been recognized as a wide-spectrum neurotoxic agent, based on laboratory studies. In the rat, Se compounds (in most cases, in its inorganic tetravalent form, selenite) were observed to enter the central nervous system (CNS) from peripheral blood vessels, showing an enhanced affi nity for the spinal cord and the hypothalamus (20) . The metalloid can alter dopamine levels in brain, exert hypothermic and nociceptive responses, impair locomotor activity (21) , interfere with prostaglandin D synthesis and activity (22) , inhibit at very…”

Section: Seleniummentioning

confidence: 99%

Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?

Vinceti

Bottecchi

Fan

et al. 2012

Reviews on Environmental Health

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The etiology of sporadic amyotrophic lateral sclerosis (ALS), the most common form of this degenerative disease of the motor neurons, is still unknown, despite extensive investigation of several genetic and environmental potential risk factors. We have reviewed laboratory and epidemiological studies assessing the role of exposure to neurotoxic chemicals (metalloid selenium; heavy metals mercury, cadmium, and lead; pesticides) in ALS etiology by summarizing the results of these investigations and examining their strengths and limitations. Despite limitations in the exposure assessment methodologies typically used in human studies, we found suggestive epidemiological evidence and biologic plausibility for an association between ALS and antecedent overexposure to environmental selenium and pesticides. The relation with mercury, cadmium, and lead appears weaker.

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Section: Seleniummentioning

confidence: 99%

Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?

Vinceti

Bottecchi

Fan

et al. 2012

Reviews on Environmental Health

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“…Among the intriguing aspects are the role of Se in the etiology of neurological disease (Vinceti et al, 2001(Vinceti et al, , 2009, also taking into account the complex peculiarities of Se physiopathology and metabolism in the brain (Buckman et al, 1993;Pullen et al, 1995;Whanger, 2001;Bou-Resli et al, 2002;Schweizer et al, 2004;Scharpf et al, 2007;Benner et al, 2013). Unfortunately, the relation between Se exposure and neurological diseases has been addressed in few human studies, in some cases affected by relevant methodological limitations, and therefore it necessitates further validation and extension.…”

Section: Introductionmentioning

confidence: 99%

Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies

et al. 2014

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Selenium is a metalloid of considerable interest in the human from both a toxicological and a nutritional perspective, with a very narrow safe range of intake. Acute selenium intoxication is followed by adverse effects on the nervous system with special clinical relevance, while the neurotoxicity of long-term overexposure is less characterized and recognized. We aimed to address this issue from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. The frequently overlooked differences in toxicity and biological activity of selenium compounds are also outlined. In addition to lethargy, dizziness, motor weakness and paresthesias, an excess risk of amyotrophic lateral sclerosis is the effect on the nervous system which has been more consistently associated with chronic low-level selenium overexposure, particularly to its inorganic compounds. Additional research efforts are needed to better elucidate the neurotoxic effects exerted by selenium overexposure.

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“…The application of a radiotracer offers diverse insights in trace element metabolism but has also specific requirements and limitations. Former investigations with the application of 75 Se (Trapp and Millam 1975; Pullen et al. 1995, 1996) and own recent studies about the selenium uptake and homeostasis in the CNS (Hoppe et al.…”

mentioning

confidence: 99%

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

Kühbacher¹,

Bartel²,

Hoppe³

et al. 2009

Journal of Neurochemistry

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The application of radionuclides for the localization of essential trace elements in vivo and the characterization of their binding proteins is a story of intermittently made improvements of the techniques used for their detection. In this study we present the use of neutron activation analysis and different autoradiographic imaging methods including real‐time digital autoradiography to reveal new insights in the hierarchy of selenium homeostasis. Selenoproteins containing the essential trace element selenium play important roles in the CNS. Although the CNS does not show the highest selenium concentration in the case of selenium‐sufficient supply in comparison with other organs, it shows a high priority for selenium uptake and retention in the case of dietary selenium deficiency. To characterize the hierarchy of selenium supply in the brain, in vivo radiotracer labeling with 75Se in rats with different selenium status was combined with autoradiographic detection of 75Se in brain tissue sections and 75Se‐labeled selenoproteins after protein separation by two‐dimensional gel electrophoresis. This study demonstrates significant differences in the uptake of 75Se into the brain of rats with different selenium status. A brain region‐specific uptake pattern of the radiotracer 75Se in selenium‐deficient rats could be revealed and the CSF was identified as a key part of the brain selenium homeostasis.

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Uptake of 75-selenium into the central nervous system of the rat

Cited by 4 publications

References 29 publications

Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?

Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis?

Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies

The brain selenoproteome: priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium‐deficient rats

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