Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity

Shesh, Bhavyata; Slagle-Webb, Becky; Shenoy, Ganesh; Khristov, Vladimir; Zacharia, Brad E.; Connor, James R.

doi:10.1007/s00432-023-04864-2

Cited by 3 publications

(1 citation statement)

References 65 publications

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“…Jaksch-Bogensperger et al observed higher serum ferritin levels in patients with high-grade glioma ( Jaksch-Bogensperger et al, 2020 ). By increasing the expression of their transferrin Receptor 1 and ferritin genes, GBM stem-like cells are better able to absorb iron from the microenvironment ( Pandya Shesh et al, 2023 ). Additionally, in high-grade gliomas, hypoxia-induced expression of the ferritin light chains is also related to the epithelial-mesenchymal transition (EMT) and chemoresistance ( Liu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Ceruloplasmin is associated with the infiltration of immune cells and acts as a prognostic biomarker in patients suffering from glioma

et al. 2023

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Glioma is regarded as a prevalent form of cancer that affects the Central Nervous System (CNS), with an aggressive growth pattern and a low clinical cure rate. Despite the advancement of the treatment strategy of surgical resection, chemoradiotherapy and immunotherapy in the last decade, the clinical outcome is still grim, which is ascribed to the low immunogenicity and tumor microenvironment (TME) of glioma. The multifunctional molecule, called ceruloplasmin (CP) is involved in iron metabolism. Its expression pattern, prognostic significance, and association with the immune cells in gliomas have not been thoroughly investigated. Studies using a variety of databases, including Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), and Gliovis, showed that the mRNA and protein expression levels of CP in patients suffering from glioma increased significantly with an increasing glioma grade. Kaplan-Meier (KM) curves and statistical tests highlighted a significant reduction in survival time of patients with elevated CP expression levels. According to Cox regression analysis, CP can be utilized as a stand-alone predictive biomarker in patients suffering from glioma. A significant association between CP expression and numerous immune-related pathways was found after analyzing the data using the Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA). Tumor Immune Estimation Resource (TIMER) and CIBERSORT analyses indicated a substantial correlation between the CP expression and infiltration of immunocytes in the TME. Additionally, immune checkpoints and CP expression in gliomas showed a favorable correlation. According to these results, patients with glioma have better prognoses and levels of tumor immune cell infiltration when their CP expression is low. As a result, CP could be used as a probable therapeutic target for gliomas and potentially anticipate the effectiveness of immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Ceruloplasmin is associated with the infiltration of immune cells and acts as a prognostic biomarker in patients suffering from glioma

et al. 2023

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Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

Pandya Shesh,

Walter,

Palsa

et al. 2023

J Neurooncol

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A closer look at the role of iron in glioblastoma

Shenoy

Connor

2023

Neuro-Oncology

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Glioblastoma is among the deadliest malignancies facing modern oncology. While our understanding of certain aspects of glioblastoma biology has significantly increased over the last decade, other aspects, such as the role of bioactive metals in glioblastoma progression, have remain understudied. Iron is the most abundant transition metal found within the earth’s crust and plays an intricate role in human physiology owing to its ability to participate in oxidation-reduction reactions. The importance of iron homeostasis in human physiology is apparent when examining the clinical consequences of iron deficiency or iron overload. Despite this, the role of iron in glioblastoma progression has not been well described. Here we review and synthesize the existing literature examining iron’s role in glioblastoma progression and patient outcomes, as well as provide a survey of iron’s effects on the major cell types found within the glioblastoma microenvironment at the molecular and cellular level. Iron represents an accessible target given the availability of already approved iron supplements and chelators. Improving our understanding of iron’s role in glioblastoma biology may pave the way for iron modulating approaches to improve patient outcomes.

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Uptake of H-ferritin by Glioblastoma stem cells and its impact on their invasion capacity

Cited by 3 publications

References 65 publications

Ceruloplasmin is associated with the infiltration of immune cells and acts as a prognostic biomarker in patients suffering from glioma

Ceruloplasmin is associated with the infiltration of immune cells and acts as a prognostic biomarker in patients suffering from glioma

Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma

A closer look at the role of iron in glioblastoma

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