Uptake of hydrogel particles with different stiffness and its influence on HepG2 cell functions

Liu, Weijun; Zhou, Xiangyan; Mao, Zhengwei; Yu, Dahai; Wang, Bing; Gao, Changyou

doi:10.1039/c2sm26001h

Cited by 110 publications

(110 citation statements)

References 44 publications

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“…306,307 Soft nanoparticles enter cells through macropinocytosis, while stiff nanoparticles enter through clathrin-mediated endocytosis. Nanoparticles with an intermediate stiffness have multiple internalization routes.…”

Section: Nanoparticle-cell Interactionsmentioning

confidence: 99%

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

et al. 2014

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Section: Nanoparticle-cell Interactionsmentioning

confidence: 99%

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

et al. 2014

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“…Different pharmacological inhibitors, including 2 mM amiloride-HCl, 1 mM amantadine-HCl, 100 mM genistein were used to treat the HepG2-Luc cells for 0.5 h before transfection and then incubated with the complexes following the procedure above [38].…”

Section: Fluorescence-activated Cell Sorting (Facs)mentioning

confidence: 99%

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

Han

Cheng

et al. 2015

Biomaterials

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“…Similarly for hydrogel discs, Merkel et al demonstrated prolonged circulation for particles with diameter comparable to RBCs, as compared to smaller particles of identical composition [46]. As discussed later in this review, carrier mechanical flexibility can generally confound trends relating clearance time to particle size, where softer particles generally exhibit longer circulation times related to altered hemodynamic behavior [43, 47] and interactions with phagocytic cells [48,49]. …”

Section: Modulation Of Pharmacokinetics and Targeting By Carrier Gmentioning

confidence: 99%

Non-affinity factors modulating vascular targeting of nano- and microcarriers

Myerson¹,

Anselmo

Liu

et al. 2016

Advanced Drug Delivery Reviews

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Particles capable of homing and adhering to specific vascular biomarkers have potential as fundamental tools in drug delivery for mediation of a wide variety of pathologies, including inflammation, thrombosis, and pulmonary disorders. The presentation of affinity ligands on the surface of a particle provides a means of targeting the particle to sites of therapeutic interest, but a host of other factors come into play in determining the targeting capacity of the particle. This review presents a summary of several key considerations in nano- and microparticle design that modulate targeted delivery without directly altering epitope-specific affinity. Namely, we describe the effect of factors in definition of the base carrier (including shape, size, and flexibility) on the capacity of carriers to access, adhere to, and integrate in target biological milieus. Furthermore, we present a summary of fundamental dynamics of carrier behavior in circulation, taking into account interactions with cells in circulation and the role of hemodynamics in mediating the direction of carriers to target sites. Finally, we note non-affinity aspects to uptake and intracellular trafficking of carriers in target cells. In total, recent findings presented here may offer an opportunity to capitalize on mitigating factors in the behavior of ligand-targeted carriers in order to optimize targeting.

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Uptake of hydrogel particles with different stiffness and its influence on HepG2 cell functions

Cited by 110 publications

References 44 publications

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery

Non-affinity factors modulating vascular targeting of nano- and microcarriers

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